Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Depression - Major Depressive Disorder: early-phase trial registry
19 of 20 indexed Depression - Major Depressive Disorder trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #848 of 28,707 conditions by registered trial count.
20 US clinical trials · 19 currently recruiting · #848 of 28,707 conditions by registered trial count
Depression - Major Depressive Disorder: 20 US clinical trials tracked, 19 recruiting.
Depression - Major Depressive Disorder is the subject of 20 registered US clinical trials on ClinicalTrials.gov, 19 of them currently open to new participants. 1 are in Phase 3-4 (later-stage) and 4 in Phase 1-2 (earlier-stage). The most active sponsor is Medical University of South Carolina, running 4 of these trials.
Enrollment posture brief
Registry condition depression-major-depressive-disorder
OPEN 19 | RECR 95% | LATE 1 | EARLY 4 | RANK #848 | SPON 4
Volume-matched condition peers
Nearest open-share peer: Pancreatic Ductal Adenocarcinoma (PDAC) (94% recruiting · 17 trials)
Depression - Major Depressive Disorder lists 19 open slots (95% of 20 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Depression - Major Depressive Disorder on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Depression - Major Depressive Disorder is recruiting above its size-band peers.
19 of 20 indexed trials (95%) are open to enrollment, against a 39.7% average across 762 conditions with 20-99 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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One sponsor concentrates Depression - Major Depressive Disorder research.
Medical University of South Carolina accounts for 4 of 20 trials (20%). 16 distinct sponsors appear on at least one study for this condition label.
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Most Depression - Major Depressive Disorder trials plan to enrol fewer than 100 people.
Median target enrolment is 67 among the 20 trials that report a genuine target (sentinel values excluded). 13 of those (65%) plan for fewer than 100 participants.
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Depression - Major Depressive Disorder research is mostly interventional.
18 interventional and 2 observational studies make up this index (90% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
20 total, page 1 of 1
A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder
Cybin IRL Limited
NCT06793397
Development of Attentional Biases for Affective Cues in Infants of Mothers With Depression
Binghamton University
NCT06835855
Mindful Self-Compassion to Address PTSD and Substance Use in Unhoused Women
University of California, Los Angeles
NCT06646692
The Effect of PROSE or Scleral Lenses on Mental Health
Boston Sight
NCT07195721
Behavioral Health Collaborative Care Model in Post-ICU Clinic Family Pilot
Medical University of South Carolina
NCT07390786
Behavioral Health Collaborative Care Model in an ICU Recovery Clinic
Medical University of South Carolina
NCT07372586
Comparing the Efficacy of Heated Yoga and Sauna as a Treatment for Depression
Massachusetts General Hospital
NCT07082998
Combining rTMS & Aerobic Exercise to Treat Depression and Improve Post-Stroke Walking
Medical University of South Carolina
NCT07050355
Preliminary Efficacy Trial of a Digital Intervention for Depression and Cannabis Use
Massachusetts General Hospital
NCT06878859
Modulating Spinal Interoceptive Pathways to Evaluate Their Role and Therapeutic Potential in MDD Symptomatic Domains
University of Cincinnati
NCT06795451
Digital Intervention for Physical Activity
Auburn University
NCT07130734
Open-Label Psilocybin Study in Transdiagnostic Population
Yale University
NCT06442423
Individualized Non-invasive Brain Stimulation for the Treatment of Major Depressive Disorder
Pulvinar Neuro
NCT06874374
Virtual Reality-Enhanced Behavioral Activation for Older Adults With Depression
Stanford University
NCT07188623
RECOVERS - Realigning Emotion and COgnition Via prEcision Regulation networkS
Medical University of South Carolina
NCT05977439
Personalized Ultrasonic Brain Stimulation for Depression (R61)
Brian Mickey
NCT06902298
IMST for Dementia Risk Reduction
Florida State University
NCT07349706
Meditative Neurofeedback for Depression
University of California, San Diego
NCT06675240
Use of a Generative AI (Gen-AI) Chatbot for Anxiety and Depression Among Persons With Cannabis Use
Trustees of Dartmouth College
NCT06920238
Theta Burst Stimulation for Refractory Depression in Autism Spectrum Disorder
Children's Hospital Medical Center, Cincinnati
NCT06670040
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 4 |
| Phase 3 | 1 |
Top Sponsors
Named interventions
Most-linked intervention names on Depression - Major Depressive Disorder records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Depression - Major Depressive Disorder trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Depression - Major Depressive Disorder page
20 registered trials, 19 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 19 Depression - Major Depressive Disorder trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Medical University of South Carolina sponsors the most Depression - Major Depressive Disorder trials on record, review their full trial history before evaluating a specific study. See Medical University of South Carolina's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Depression - Major Depressive Disorder condition card totals 20 registered trials; most-linked intervention Transcranial Magnetic Stimulation Sham; top US site state South Carolina. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.