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NCT06874374 · ClinicalTrials.gov registry record · NA
Individualized Non-invasive Brain Stimulation for the Treatment of Major Depressive Disorder
A NA study of Depression - Major Depressive Disorder and Transcranial Alternating Current Stimulation, sponsored by Pulvinar Neuro.
- Recruiting
- Registry status
- NA
- Development phase
- 40
- Enrollment target
- 1
- Study location
NCT06874374: Recruiting NA study of Depression - Major Depressive Disorder and Transcranial Alternating Current Stimulation, sponsored by Pulvinar Neuro.
NCT06874374 is a NA study of Depression - Major Depressive Disorder and Transcranial Alternating Current Stimulation that is actively recruiting participants, run by Pulvinar Neuro. The registered enrollment target is 40 participants, below the 100-participant average among 19 other Depression - Major Depressive Disorder trials with a reported enrollment target (60% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06874374, a NA study of Depression - Major Depressive Disorder and Transcranial Alternating Current Stimulation, is actively recruiting participants, sponsored by Pulvinar Neuro.
- RECRUITING
- Registry status
- NA
- Development phase
- 40 participants
- Enrollment target
- 1
- Study location
Study Summary
The purpose of this research study is to study a closed-loop transcranial alternating current stimulation (tACS) device to evaluate feasibility of the product in a clinical trial and collect preliminary data on potential effects on symptoms of depression in people with major depressive disorder.
Primary Outcome
Successful assignment by device software to correct study arm for each participant for each session, Day 1 (D1) through Day 5 (D5). Measured as percentage of successful assignments compared to intended programming.
Conditions Studied
Interventions
- DEVICE Sham Comparator
- DEVICE Closed-loop tACS
Study Locations (1)
North Carolina
- Carolina Center for Neurostimulation - Chapel Hill
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 40 participants |
| Start Date | 2025-04-11 |
| Est. Completion | 2026-02-28 |
| Phase | NA |
What NCT06874374 shows while recruiting
NCT06874374 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 40 participants, a relatively small participant target, below the 100-participant average among 19 other Depression - Major Depressive Disorder trials with a reported enrollment target (60% lower).
The record links to 2 conditions, with Depression - Major Depressive Disorder appearing as the primary indexed condition, and to 2 interventions - of which Sham Comparator is the first listed.
NCT06874374 reports a single indexed study location in North Carolina.
Frequently Asked Questions
What is clinical trial NCT06874374 about?
NCT06874374 is a clinical study titled "Individualized Non-invasive Brain Stimulation for the Treatment of Major Depressive Disorder". The purpose of this research study is to study a closed-loop transcranial alternating current stimulation (tACS) device to evaluate feasibility of the product in a clinical trial and collect preliminary data on potential effects on symptoms of depression in people with major depressive disorder.
What is the current status of trial NCT06874374?
This trial is currently recruiting. It is a NA study. The enrollment target is 40 participants. The study started on 2025-04-11. Estimated completion is 2026-02-28.
What conditions does trial NCT06874374 study?
This clinical trial studies the following conditions: Depression - Major Depressive Disorder, Transcranial Alternating Current Stimulation.
What interventions are being tested in trial NCT06874374?
The interventions under investigation include: Sham Comparator (DEVICE), Closed-loop tACS (DEVICE).
Who is sponsoring clinical trial NCT06874374?
This trial is sponsored by Pulvinar Neuro, which has 1 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06874374 being conducted?
This trial has 1 study location across North Carolina. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Depression - Major Depressive Disorder
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06874374's enrollment target sits among peer trials
40 13th of 19 higher than 7 of 19 other Depression - Major Depressive Disorder trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Depression - Major Depressive Disorder trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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