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NCT07050355 · ClinicalTrials.gov registry record · NA
Combining rTMS & Aerobic Exercise to Treat Depression and Improve Post-Stroke Walking
A NA study of Stroke and Depression - Major Depressive Disorder, sponsored by Medical University of South Carolina.
- Recruiting
- Registry status
- NA
- Development phase
- 96
- Enrollment target
- 2
- Study locations
NCT07050355: Recruiting NA study of Stroke and Depression - Major Depressive Disorder, sponsored by Medical University of South Carolina.
NCT07050355 is a NA study of Stroke and Depression - Major Depressive Disorder that is actively recruiting participants, run by Medical University of South Carolina. The registered enrollment target is 96 participants, below the 12,016-participant average among 454 other Stroke trials with a reported enrollment target (99% lower). The trial reports 2 study locations across 2 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07050355, a NA study of Stroke and Depression - Major Depressive Disorder, is actively recruiting participants, sponsored by Medical University of South Carolina.
- RECRUITING
- Registry status
- NA
- Development phase
- 96 participants
- Enrollment target
- 2
- Study locations
Study Summary
Investigators primary aim is to carry out a two-site, randomized, double-blind, sham-controlled, phase II trial to systematically examine the potential for aerobic exercise (AEx) to enhance the anti-depressant benefits of rTMS in individuals with post-stroke depression (PSD). Investigators propose to determine the efficacy of combining two known anti-depressant treatments shown to be effective in non-stroke depression, aerobic exercise (AEx) and repetitive transcranial magnetic stimulation (rTMS), on post-stroke depressive symptoms. This project is based on the idea that depression negatively affects the potential for the brain to adapt in response to treatment such that rehabilitation may not produce the same changes that it does in non-depressed individuals. Investigators believe that effective treatment for PSD will result in a virtuous cycle whereby reducing depression enhances response to rehabilitation, thereby facilitating functional gains. That is, effectively treating depression will enable individuals to better recover from stroke.
Primary Outcome
The Hamilton Depression Rating Scale (HAM-D17) is the gold-standard for clinical trial outcomes and samples a broad array of depressive symptoms. Critically, the rater administering the HAM-D17 will be clinically trained and will blinded to all other aspects of the study. For this trial, depression severity will be classified as moderate (HAM-D17 = 14-19) or severe (HAM-D = 20-25) for the purpose of stratification and diagnosed upon enrollment using the Structured Clinical Interview for Depressi
Conditions Studied
Interventions
- DEVICE rTMS
- BEHAVIORAL AEx
Study Locations (2)
North Carolina
- Duke University School of Medicine - Durham
South Carolina
- Medical University of South Carolina - Charleston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 96 participants |
| Start Date | 2024-11-01 |
| Est. Completion | 2029-08-31 |
| Phase | NA |
What NCT07050355 shows while recruiting
NCT07050355 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 96 participants, a relatively small participant target, below the 12,016-participant average among 454 other Stroke trials with a reported enrollment target (99% lower).
The record links to 3 conditions, with Stroke appearing as the primary indexed condition, and to 2 interventions - of which rTMS is the first listed.
NCT07050355 reports a single indexed study location in North Carolina, South Carolina.
Frequently Asked Questions
What is clinical trial NCT07050355 about?
NCT07050355 is a clinical study titled "Combining rTMS & Aerobic Exercise to Treat Depression and Improve Post-Stroke Walking". Investigators primary aim is to carry out a two-site, randomized, double-blind, sham-controlled, phase II trial to systematically examine the potential for aerobic exercise (AEx) to enhance the anti-depressant benefits of rTMS in individuals with post-stroke depression (PSD). Investigators propose ...
What is the current status of trial NCT07050355?
This trial is currently recruiting. It is a NA study. The enrollment target is 96 participants. The study started on 2024-11-01. Estimated completion is 2029-08-31.
What conditions does trial NCT07050355 study?
This clinical trial studies the following conditions: Stroke, Depression - Major Depressive Disorder, Walking Impairment.
What interventions are being tested in trial NCT07050355?
The interventions under investigation include: rTMS (DEVICE), AEx (BEHAVIORAL).
Who is sponsoring clinical trial NCT07050355?
This trial is sponsored by Medical University of South Carolina, which has 755 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07050355 being conducted?
This trial has 2 study locations across North Carolina, South Carolina. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT07050355's enrollment target sits among peer trials
96 149th of 454 higher than 305 of 454 other Stroke trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Stroke trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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