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NCT05977439 · ClinicalTrials.gov registry record

RECOVERS - Realigning Emotion and COgnition Via prEcision Regulation networkS

A clinical trial of Healthy and Depression - Major Depressive Disorder, sponsored by Medical University of South Carolina.

Recruiting
Registry status
30
Enrollment target
1
Study location

NCT05977439: Recruiting study of Healthy and Depression - Major Depressive Disorder, sponsored by Medical University of South Carolina.

NCT05977439 is a study of Healthy and Depression - Major Depressive Disorder that is actively recruiting participants, run by Medical University of South Carolina. The registered enrollment target is 30 participants, below the 647-participant average among 1,090 other Healthy trials with a reported enrollment target (95% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.

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The verdict

NCT05977439, a study of Healthy and Depression - Major Depressive Disorder, is actively recruiting participants, sponsored by Medical University of South Carolina.

RECRUITING
Registry status
30 participants
Enrollment target
1
Study location

Study Summary

In this research study, the investigators are examining how brain activity (electrical and blood flow) changes during tests of emotional processing, attention and memory in the magnetic resonance imaging (MRI) scanner and outside the MRI using functional near-infrared spectroscopy (fNIRS). Investigators are also using non-invasive brain stimulation to probe different parts of the brain and measuring brain activity (electrical and blood flow). Study 1 This study includes healthy participants and researchers hope this will help us develop improved brain-based treatments for emotional difficulties like depression. Study 2 This study includes participants with depression and researchers hope this will help us develop improved brain-based treatments for emotional difficulties like depression.

Primary Outcome

hange in clinician-rated depression severity measured using the Hamilton Depression Rating Scale (HAM-D). Scores range from 0 to 52; higher scores indicate more severe depression.

Conditions Studied

Healthy Depression - Major Depressive Disorder

Interventions

  • DEVICE fMRI-EEG-TMS
  • DEVICE fNIRS-EEG-TMS
  • DEVICE fNIRS-EEG-rTMS Interleaved with CBT

Study Locations (1)

South Carolina

  • Medical Univeristy of South Carolina - Charleston

Trial Details

FieldValue
Enrollment Target 30 participants
Start Date 2024-02-01
Est. Completion 2028-10-01
Medical University of South Carolina

755 total trials

What NCT05977439 shows while recruiting

NCT05977439 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 30 participants, a relatively small participant target, below the 647-participant average among 1,090 other Healthy trials with a reported enrollment target (95% lower).

The record links to 2 conditions, with Healthy appearing as the primary indexed condition, and to 3 interventions - of which fMRI-EEG-TMS is the first listed.

NCT05977439 reports a single indexed study location in South Carolina.

Frequently Asked Questions

What is clinical trial NCT05977439 about?

NCT05977439 is a clinical study titled "RECOVERS - Realigning Emotion and COgnition Via prEcision Regulation networkS". In this research study, the investigators are examining how brain activity (electrical and blood flow) changes during tests of emotional processing, attention and memory in the magnetic resonance imaging (MRI) scanner and outside the MRI using functional near-infrared spectroscopy (fNIRS). Investiga...

What is the current status of trial NCT05977439?

This trial is currently recruiting. The enrollment target is 30 participants. The study started on 2024-02-01. Estimated completion is 2028-10-01.

What conditions does trial NCT05977439 study?

This clinical trial studies the following conditions: Healthy, Depression - Major Depressive Disorder.

What interventions are being tested in trial NCT05977439?

The interventions under investigation include: fMRI-EEG-TMS (DEVICE), fNIRS-EEG-TMS (DEVICE), fNIRS-EEG-rTMS Interleaved with CBT (DEVICE).

Who is sponsoring clinical trial NCT05977439?

This trial is sponsored by Medical University of South Carolina, which has 755 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT05977439 being conducted?

This trial has 1 study location across South Carolina. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Learn More About Clinical Trials

Similar trials for Healthy

Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.

Where NCT05977439's enrollment target sits among peer trials

30 678th of 1090 higher than 363 of 1,090 other Healthy trials

participants (enrollment target), bucketed by value

Each bar is a band; taller bars hold more other Healthy trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.

Source ClinicalTrials.gov registry export · 2026-08-08

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More recruiting context for NCT05977439

Source: ClinicalTrials.gov NCT05977439, the US trial registry maintained by the National Library of Medicine. NCT05977439 (small enrollment · single site footprint · recruiting) retrieved and formatted by PlainTrial, see methodology.