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NCT06878859 · ClinicalTrials.gov registry record · NA
Preliminary Efficacy Trial of a Digital Intervention for Depression and Cannabis Use
A NA study of Cannabis Use Disorder and Mental Disorder, sponsored by Massachusetts General Hospital.
- Recruiting
- Registry status
- NA
- Development phase
- 80
- Enrollment target
- 1
- Study location
NCT06878859: Recruiting NA study of Cannabis Use Disorder and Mental Disorder, sponsored by Massachusetts General Hospital.
NCT06878859 is a NA study of Cannabis Use Disorder and Mental Disorder that is actively recruiting participants, run by Massachusetts General Hospital. The registered enrollment target is 80 participants, below the 107-participant average among 34 other Cannabis Use Disorder trials with a reported enrollment target (25% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06878859, a NA study of Cannabis Use Disorder and Mental Disorder, is actively recruiting participants, sponsored by Massachusetts General Hospital.
- RECRUITING
- Registry status
- NA
- Development phase
- 80 participants
- Enrollment target
- 1
- Study location
Study Summary
The purpose of this study is to examine the feasibility, acceptability, and preliminary efficacy of a digital intervention for co-occurring cannabis use and depression. Participants will be randomized to complete Amplification of Positivity - Cannabis Use (AMP-C) or symptom tracking. The main outcomes will include changes in depressive symptoms and cannabis use, as well as usability ratings.
Primary Outcome
Depressive symptoms will be measured with the Patient Health Questionnaire-9 (PHQ-9). The PHQ-9 is a widely-used 9-item self-report measure that assesses depressive symptom severity over the previous two weeks. Scores on the PHQ-9 range from 0-27, with greater scores indicating greater depression severity.
Conditions Studied
Interventions
- BEHAVIORAL Amplification of Positivity - Cannabis Use (AMP-C)
Study Locations (1)
Massachusetts
- Massachusetts General Hospital - Boston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 80 participants |
| Start Date | 2026-02 |
| Est. Completion | 2029-01 |
| Phase | NA |
What NCT06878859 shows while recruiting
NCT06878859 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 80 participants, a relatively small participant target, below the 107-participant average among 34 other Cannabis Use Disorder trials with a reported enrollment target (25% lower).
The record links to 3 conditions, with Cannabis Use Disorder appearing as the primary indexed condition, and to 1 intervention - of which Amplification of Positivity - Cannabis Use (AMP-C) is the first listed.
NCT06878859 reports a single indexed study location in Massachusetts.
Frequently Asked Questions
What is clinical trial NCT06878859 about?
NCT06878859 is a clinical study titled "Preliminary Efficacy Trial of a Digital Intervention for Depression and Cannabis Use". The purpose of this study is to examine the feasibility, acceptability, and preliminary efficacy of a digital intervention for co-occurring cannabis use and depression. Participants will be randomized to complete Amplification of Positivity - Cannabis Use (AMP-C) or symptom tracking. The main outcom...
What is the current status of trial NCT06878859?
This trial is currently recruiting. It is a NA study. The enrollment target is 80 participants. The study started on 2026-02. Estimated completion is 2029-01.
What conditions does trial NCT06878859 study?
This clinical trial studies the following conditions: Cannabis Use Disorder, Mental Disorder, Depression - Major Depressive Disorder.
What interventions are being tested in trial NCT06878859?
The interventions under investigation include: Amplification of Positivity - Cannabis Use (AMP-C) (BEHAVIORAL).
Who is sponsoring clinical trial NCT06878859?
This trial is sponsored by Massachusetts General Hospital, which has 2,032 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06878859 being conducted?
This trial has 1 study location across Massachusetts. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Cannabis Use Disorder
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06878859's enrollment target sits among peer trials
80 16th of 34 higher than 17 of 34 other Cannabis Use Disorder trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Cannabis Use Disorder trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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