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NCT06902298 · ClinicalTrials.gov registry record · Phase 1
Personalized Ultrasonic Brain Stimulation for Depression (R61)
A Phase 1 study of Depression - Major Depressive Disorder and Major Depressive Episode, sponsored by Brian Mickey.
- Recruiting
- Registry status
- Phase 1
- Development phase
- 30
- Enrollment target
- 1
- Study location
NCT06902298: Recruiting Phase 1 study of Depression - Major Depressive Disorder and Major Depressive Episode, sponsored by Brian Mickey.
NCT06902298 is a Phase 1 study of Depression - Major Depressive Disorder and Major Depressive Episode that is actively recruiting participants, run by Brian Mickey. The registered enrollment target is 30 participants, below the 101-participant average among 19 other Depression - Major Depressive Disorder trials with a reported enrollment target (70% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06902298, a Phase 1 study of Depression - Major Depressive Disorder and Major Depressive Episode, is actively recruiting participants, sponsored by Brian Mickey.
- RECRUITING
- Registry status
- Phase 1
- Development phase
- 30 participants
- Enrollment target
- 1
- Study location
Study Summary
This study will evaluate a new form of non-invasive brain stimulation for individuals with depression. Personalized low-intensity transcranial focused ultrasound stimulation will be delivered using a range of stimulation parameters during psychological and physiological monitoring. Individualized optimal targets will be selected using structural MRI and diffusion tractography. Brain target engagement will be evaluated using functional MRI.
Primary Outcome
Functional MRI is used to quantify modulation of SCC activity during SCC stimulation
Conditions Studied
Interventions
- DEVICE LTFUS to SCC
- DEVICE LTFUS to ALIC
Study Locations (1)
Utah
- University of Utah - Salt Lake City
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 30 participants |
| Start Date | 2025-03-10 |
| Est. Completion | 2026-11 |
| Phase | Phase 1 |
What NCT06902298 shows while recruiting
NCT06902298 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 30 participants, a relatively small participant target, below the 101-participant average among 19 other Depression - Major Depressive Disorder trials with a reported enrollment target (70% lower).
The record links to 3 conditions, with Depression - Major Depressive Disorder appearing as the primary indexed condition, and to 2 interventions - of which LTFUS to SCC is the first listed.
NCT06902298 reports a single indexed study location in Utah.
Frequently Asked Questions
What is clinical trial NCT06902298 about?
NCT06902298 is a clinical study titled "Personalized Ultrasonic Brain Stimulation for Depression (R61)". This study will evaluate a new form of non-invasive brain stimulation for individuals with depression. Personalized low-intensity transcranial focused ultrasound stimulation will be delivered using a range of stimulation parameters during psychological and physiological monitoring. Individualized op...
What is the current status of trial NCT06902298?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 30 participants. The study started on 2025-03-10. Estimated completion is 2026-11.
What conditions does trial NCT06902298 study?
This clinical trial studies the following conditions: Depression - Major Depressive Disorder, Major Depressive Episode, Treatment-Resistant Major Depressive Disorder.
What interventions are being tested in trial NCT06902298?
The interventions under investigation include: LTFUS to SCC (DEVICE), LTFUS to ALIC (DEVICE).
Who is sponsoring clinical trial NCT06902298?
This trial is sponsored by Brian Mickey, which has 1 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06902298 being conducted?
This trial has 1 study location across Utah. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Depression - Major Depressive Disorder
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06902298's enrollment target sits among peer trials
30 14th of 19 higher than 3 of 19 other Depression - Major Depressive Disorder trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Depression - Major Depressive Disorder trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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