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ClinicalTrials.gov 37 recruiting now official registry

Crohn's Disease clinical trials

37 of 106 indexed Crohn's Disease trials are currently recruiting.

106 US clinical trials · 37 currently recruiting

Crohn's Disease is the subject of 106 registered US clinical trials on ClinicalTrials.gov, 37 of them currently open to new participants. 46 are in Phase 3-4 (later-stage) and 36 in Phase 1-2 (earlier-stage). The most active sponsor is Takeda, running 13 of these trials.

The research picture

Crohn's Disease has 106 registered US clinical trials, 37 of them open to new participants right now, about 35% of the total.

37
recruiting participants now
35%
of trials open to enrollment
46
in Phase 3–4 (later-stage)
13
top sponsor: Takeda
Phase 114Phase 222Phase 341Phase 45

Active & Recent Trials

106 total, page 2 of 3

ACTIVE NOT RECRUITING NA 40 participants

Dietary Therapy and Gut Microbiome in Crohn's Disease and Ulcerative Colitis

Massachusetts General Hospital

NCT02412553

ACTIVE NOT RECRUITING Phase 2 21 participants

Afimkibart (RO7790121) for the Treatment of Moderate to Severe Active Crohn's Disease

Hoffmann-La Roche

NCT05910528

ACTIVE NOT RECRUITING Phase 1 7 participants

Study to Evaluate Safety, Tolerability and Efficacy of Oral E-B-FAHF-2 in Mild-to-Moderate Crohn's Disease

Icahn School of Medicine at Mount Sinai

NCT03992469

COMPLETED 200,000 participants

General Surgical Outcomes Quality Improvement Database (UH-SOCRATES)

University Hospitals Cleveland Medical Center

NCT00622557

COMPLETED Phase 3 1,158 participants

A Study of Mirikizumab (LY3074828) in Participants With Crohn's Disease

Eli Lilly and Company

NCT03926130

COMPLETED 974 participants

Study to Determine Risk Factors for Post-operative Infection in Inflammatory Bowel Disease

Icahn School of Medicine at Mount Sinai

NCT02054533

COMPLETED Phase 3 854 participants

Adalimumab for the Induction and Maintenance of Clinical Remission in Subjects With Crohn's Disease

Abbott

NCT00077779

COMPLETED Phase 3 777 participants

Long-term Safety and Tolerability Study of Adalimumab in Subjects With Crohn's Disease

Abbott

NCT00195715

COMPLETED Phase 3 769 participants

A Study to Evaluate the Safety and Efficacy of Ustekinumab in Patients With Moderately to Severely Active Crohn's Disease Who Have Failed or Are Intolerant to Tumor Necrosis Factor (TNF) Antagonist Therapy (UNITI-1)

Janssen Research & Development

NCT01369329

COMPLETED Phase 3 644 participants

Efficacy and Safety of Vedolizumab Subcutaneous (SC) as Maintenance Therapy in Crohn's Disease (CD)

Takeda

NCT02611817

COMPLETED Phase 3 624 participants

A Study of the Efficacy and Safety of Upadacitinib (ABT-494) in Participants With Moderately to Severely Active Crohn's Disease Who Have Inadequately Responded to or Are Intolerant to Biologic Therapy

AbbVie

NCT03345836

COMPLETED Phase 3 526 participants

A Study of the Efficacy and Safety of Upadacitinib in Participants With Moderately to Severely Active Crohn's Disease Who Have Inadequately Responded to or Are Intolerant to Conventional and/or Biologic Therapies

AbbVie

NCT03345849

COMPLETED Phase 3 514 participants

Study to Evaluate Efficacy and Safety of Two Drug Regimens in Subjects With Moderate to Severe Crohn's Disease

AbbVie

NCT02065570

COMPLETED 465 participants

Comparative Effectiveness of Biologics or Small Molecule Therapies in Inflammatory Bowel Disease (IBD)

University of North Carolina, Chapel Hill

NCT04852666

COMPLETED Phase 3 462 participants

A Clinical Trial of Natalizumab in Individuals With Moderately to Severely Active Crohn's Disease

Biogen

NCT00078611

COMPLETED 376 participants

Pregnancy Exposure Registry for Tysabri®

Biogen

NCT00472992

COMPLETED Phase 3 364 participants

An Efficacy and Safety Study of Omega-3 Free Fatty Acids (Epanova™) for the Maintenance of Symptomatic Remission in Subjects With Crohn's Disease

Tillotts Pharma

NCT00074542

COMPLETED Phase 3 348 participants

Telemedicine in Patients With Inflammatory Bowel Disease (TELE-IBD)

University of Maryland, Baltimore

NCT01692743

COMPLETED NA 320 participants

Trial on Impact of HealthPROMISE Mobile App on Inflammatory Bowel Disease Care and Quality of Life

Icahn School of Medicine at Mount Sinai

NCT02322307

COMPLETED Phase 3 310 participants

A follow-on Safety Study in Subjects With Crohn's Disease Who Have Previously Been Withdrawn From the Double-blind Study CDP870-031 [NCT00152490] or CDP870-032 [NCT00152425] Due to an Exacerbation of Crohn's Disease

UCB Pharma

NCT00160706

COMPLETED Phase 3 304 participants

Human Anti-TNF Monoclonal Antibody Adalimumab in Canadian Subjects With Moderate to Severe Crohn's Disease (ACCESS)

Abbott

NCT00427921

COMPLETED Phase 2 300 participants

A Study of the Human Anti-TNF Antibody Adalimumab for the Induction of Clinical Remission in Subjects With Crohn's Disease

Abbott

NCT00055523

COMPLETED Phase 3 276 participants

Remission in Subjects With Crohn's Disease, 1 Year Phase

Abbott

NCT00055497

COMPLETED Phase 2 268 participants

A Study To Monitor Long-Term Treatment With PF-00547659

Shire

NCT01298492

COMPLETED Phase 3 250 participants

Safety and Efficacy Study of Oral Ferric Maltol Compared to Intravenous Iron To Treat Iron Deficiency Anaemia in IBD

Shield Therapeutics

NCT02680756

COMPLETED Phase 3 235 participants

Study for the Treatment of Crohn's Disease With Adacolumn

Otsuka America Pharmaceutical

NCT00162942

COMPLETED Phase 3 220 participants

Demonstrate Noninferiority in Efficacy and to Assess Safety of CT-P13 in Patients With Active Crohn's Disease

Celltrion

NCT02096861

COMPLETED NA 204 participants

Evaluating a Shared Decision Making Program for Crohn's Disease

Dartmouth-Hitchcock Medical Center

NCT02084290

COMPLETED Phase 3 192 participants

Efficacy and Safety of Adalimumab in Pediatric Subjects With Moderate to Severe Crohn's Disease

Abbott

NCT00409682

COMPLETED Phase 2 180 participants

The Safety And Efficacy Of Maintenance Therapy With CP-690,550

Pfizer

NCT01393899

COMPLETED NA 140 participants

Improving Medication Adherence in Pediatric Inflammatory Bowel Disease

Children's Hospital Medical Center, Cincinnati

NCT01536509

COMPLETED Phase 2 139 participants

A Study to Investigate the Safety and Efficacy of CP-690,550 in Patients With Moderate to Severe Crohn's Disease

Pfizer

NCT00615199

COMPLETED Phase 2 121 participants

Induction and Maintenance Study of BMS-936557 in Patients With Moderate to Severely Active Crohn's Disease

Bristol-Myers Squibb

NCT01466374

COMPLETED 106 participants

Adherence to Mesalamine Profile for Patients With Inflammatory Bowel Disease

Beth Israel Deaconess Medical Center

NCT01349504

COMPLETED Phase 3 101 participants

Effect of Intravenous (IV) Vedolizumab on Mucosal Healing in Crohn's Disease

Takeda

NCT02425111

COMPLETED Phase 2 75 participants

FolateScan in Autoimmune Disease

Mayo Clinic

NCT00588393

COMPLETED Phase 1 73 participants

Dietary Treatment of Crohn's Disease

Rush University Medical Center

NCT00343642

COMPLETED Phase 3 69 participants

An Assessment of Goal-Directed Intraoperative Fluid Management in Hand Assisted Laparoscopic Colectomy

Corewell Health West

NCT00467922

COMPLETED 67 participants

Intestinal Wall Remodeling (Infliximab Therapy) in Crohn's Disease Patients Undergoing Serial Computed Tomography (CT) Enterography

Mayo Clinic

NCT00819663

COMPLETED Phase 2 60 participants

Safety and Efficacy of Natalizumab in Combination With Remicade in the Treatment of Crohn's Disease

Biogen

NCT00055536

COMPLETED Phase 2 59 participants

Long-term Safety With Vedolizumab Intravenous (IV) in Pediatric Participants With Ulcerative Colitis (UC) or Crohn's Disease (CD)

Takeda

NCT03196427

COMPLETED Phase 3 55 participants

Safety and Maintenance Study of Entocort for Children With Crohn's Disease

Padagis

NCT01453946

COMPLETED Phase 1 43 participants

Study to Evaluate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of AMG 181.

Amgen

NCT01290042

COMPLETED Phase 1 40 participants

Use of Oral Probiotics to Reduce Urinary Oxalate Excretion

Mayo Clinic

NCT00587041

COMPLETED Phase 1 40 participants

Evaluation of a PillCam Colon Bowel Preparation Regimen in Crohn's Disease Patients

Medtronic - MITG

NCT01576120

COMPLETED Phase 2 36 participants

Induction of Clinical Response Using Rifaximin in Crohn's Disease

Scott Lee

NCT00603616

COMPLETED NA 31 participants

Protein Metabolism in Newly Diagnosed Pediatric Inflammatory Bowel Disease

Indiana University

NCT00586352

COMPLETED Phase 4 31 participants

Centocor Microarray Study of Patients

University of Rochester

NCT00462072

COMPLETED Phase 1 30 participants

Single Ascending Dose Study of Oral CPSI-2364 (Semapimod)

Ferring Pharmaceuticals

NCT00950105

COMPLETED Phase 2 30 participants

CP-461 for the Treatment of Crohn's Disease

Astellas Pharma

NCT00042055

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Phase Distribution

PhaseTrial count
Phase 1 14
Phase 2 22
Phase 3 41
Phase 4 5

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Crohn's Disease Trial Landscape

106 indexed Crohn's Disease studies · 37 recruiting (35%).

Phase mix: 46 late (III/IV) vs 36 early (I/II).

Top sponsor: Takeda (13 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Crohn's Disease?

PlainTrial tracks 106 US clinical trials for Crohn's Disease, of which 37 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Crohn's Disease?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.