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Treatment of Moderate to Severe Refractory Crohn's Disease
NCT06721962 · View on ClinicalTrials.gov ↗
Study Summary
This research study is testing an investigational research product called TRX103 as a possible treatment for individuals suffering from Crohn's Disease (CD). The primary purpose of this study is to learn how safe and effective different doses of TRX103 are when administered to individuals with CD.
Conditions Studied
Interventions
- DRUG Cyclophosphamide
- BIOLOGICAL TRX103
Study Locations (13)
California
- University of California, Davis — Sacramento
- University of California, San Francisco — San Francisco
Illinois
- Northwestern — Chicago
- University of Chicago — Chicago
Arizona
- Mayo Clinic Arizona — Scottsdale
Florida
- University of Florida — Gainesville
Iowa
- University of Iowa — Iowa City
Kentucky
- University of Louisville — Louisville
Michigan
- University of Michigan — Ann Arbor
Minnesota
- Mayo Clinic Rochester — Rochester
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 39 participants |
| Start Date | 2025-05-05 |
| Est. Completion | 2027-01-30 |
| Phase | Phase 1 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06721962
The ClinicalTrials.gov registry entry for NCT06721962 describes a study currently listed as recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 39 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Tr1X, which has 3 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with Crohns Disease appearing as the primary indexed condition, and to 2 interventions — of which Cyclophosphamide is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT06721962 reports 13 study locations spanning 11 distinct geographic areas — top geographies include California, Illinois, Arizona. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT06721962 about?
NCT06721962 is a clinical study titled "Treatment of Moderate to Severe Refractory Crohn's Disease". This research study is testing an investigational research product called TRX103 as a possible treatment for individuals suffering from Crohn's Disease (CD). The primary purpose of this study is to learn how safe and effective different doses of TRX103 are when administered to individuals with CD.
What is the current status of trial NCT06721962?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 39 participants. The study started on 2025-05-05. Estimated completion is 2027-01-30.
What conditions does trial NCT06721962 study?
This clinical trial studies the following conditions: Crohns Disease. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT06721962?
The interventions under investigation include: Cyclophosphamide (DRUG), TRX103 (BIOLOGICAL). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT06721962?
This trial is sponsored by Tr1X, which has 3 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT06721962 being conducted?
This trial has 13 study locations across Arizona, California, Florida, Illinois, Iowa. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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