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NCT04508088 · ClinicalTrials.gov registry record
Skeletal Health and Bone Marrow Composition in Newly Diagnosed Adolescents With Crohn Disease
A clinical trial of Crohn Disease and Inflammatory Bowel Disease, sponsored by Massachusetts General Hospital.
- Recruiting
- Registry status
- 92
- Enrollment target
- 1
- Study location
NCT04508088: Recruiting study of Crohn Disease and Inflammatory Bowel Disease, sponsored by Massachusetts General Hospital.
NCT04508088 is a study of Crohn Disease and Inflammatory Bowel Disease that is actively recruiting participants, run by Massachusetts General Hospital. The registered enrollment target is 92 participants, below the 204-participant average among 71 other Crohn Disease trials with a reported enrollment target (55% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04508088, a study of Crohn Disease and Inflammatory Bowel Disease, is actively recruiting participants, sponsored by Massachusetts General Hospital.
- RECRUITING
- Registry status
- 92 participants
- Enrollment target
- 1
- Study location
Study Summary
The investigators will be evaluating bone marrow composition via magnetic resonance imaging in newly diagnosed adolescents with Crohn disease (CD) compared to healthy, matched controls. The investigators will also be assessing their bone mineral density via other imaging modalities, including dual-energy X-ray absorptiometry and peripheral quantitative computed tomography. This longitudinal project will focus on abnormalities in bone marrow composition, and specifically whether adolescents with newly diagnosed CD exhibit increased bone marrow fat, its association with bone mineral density (BMD) and the underlying pathophysiology, including bone turnover markers and immune cellular/molecular parameters.
Primary Outcome
Change in Bone marrow adiposity measured by MRI (T1 maps)
Conditions Studied
Interventions
- DIAGNOSTIC_TEST Blood Draw
- DIAGNOSTIC_TEST Magnetic resonance spectroscopy
- DIAGNOSTIC_TEST Coronal T1 weighted spin echo images
- DIAGNOSTIC_TEST Spin-lattice relaxation (T1)
Study Locations (1)
Massachusetts
- Boston Children's Hospital - Boston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 92 participants |
| Start Date | 2020-09-10 |
| Est. Completion | 2026-12 |
What NCT04508088 shows while recruiting
NCT04508088 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 92 participants, a relatively small participant target, below the 204-participant average among 71 other Crohn Disease trials with a reported enrollment target (55% lower).
The record links to 2 conditions, with Crohn Disease appearing as the primary indexed condition, and to 4 interventions - of which Blood Draw is the first listed.
NCT04508088 reports a single indexed study location in Massachusetts.
Frequently Asked Questions
What is clinical trial NCT04508088 about?
NCT04508088 is a clinical study titled "Skeletal Health and Bone Marrow Composition in Newly Diagnosed Adolescents With Crohn Disease". The investigators will be evaluating bone marrow composition via magnetic resonance imaging in newly diagnosed adolescents with Crohn disease (CD) compared to healthy, matched controls. The investigators will also be assessing their bone mineral density via other imaging modalities, including dual-e...
What is the current status of trial NCT04508088?
This trial is currently recruiting. The enrollment target is 92 participants. The study started on 2020-09-10. Estimated completion is 2026-12.
What conditions does trial NCT04508088 study?
This clinical trial studies the following conditions: Crohn Disease, Inflammatory Bowel Disease.
What interventions are being tested in trial NCT04508088?
The interventions under investigation include: Blood Draw (DIAGNOSTIC_TEST), Magnetic resonance spectroscopy (DIAGNOSTIC_TEST), Coronal T1 weighted spin echo images (DIAGNOSTIC_TEST), Spin-lattice relaxation (T1) (DIAGNOSTIC_TEST).
Who is sponsoring clinical trial NCT04508088?
This trial is sponsored by Massachusetts General Hospital, which has 2,032 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04508088 being conducted?
This trial has 1 study location across Massachusetts. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Crohn Disease
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT04508088's enrollment target sits among peer trials
92 35th of 71 higher than 37 of 71 other Crohn Disease trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Crohn Disease trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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