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Crohn Disease clinical trials
34 of 72 indexed Crohn Disease trials are currently recruiting.
72 US clinical trials · 34 currently recruiting
Crohn Disease is the subject of 72 registered US clinical trials on ClinicalTrials.gov, 34 of them currently open to new participants. 13 are in Phase 3-4 (later-stage) and 20 in Phase 1-2 (earlier-stage). The most active sponsor is Massachusetts General Hospital, running 6 of these trials.
The research picture
Crohn Disease has 72 registered US clinical trials, 34 of them open to new participants right now, about 47% of the total.
- 34
- recruiting participants now
- 47%
- of trials open to enrollment
- 13
- in Phase 3–4 (later-stage)
- 6
- top sponsor: Massachusetts General Hospital
Active & Recent Trials
72 total, page 2 of 2
Safety and Efficacy of Adalimumab Versus Ustekinumab for One Year
Janssen Scientific Affairs
NCT03464136
A Study to Test the Effect of TEV-48574 in Moderate to Severe Ulcerative Colitis or Crohn's Disease
Teva Branded Pharmaceutical Products R&D
NCT05499130
Clinical Study Comparing PillCam® Crohn's Capsule Endoscopy to Ileocolonoscopy (IC) Plus MRE for Detection of Active CD in the Small Bowel and Colon in Subjects With Known CD and Mucosal Disease.
Medtronic - MITG
NCT03241368
BI 695501 Versus Humira in Patients With Active Crohn's Disease: a Trial Comparing Efficacy, Endoscopic Improvement, Safety, and Immunogenicity
Boehringer Ingelheim
NCT02871635
Intraoperative TAP Block With Bupivacaine/Dexamethasone Against Liposomal Bupivacaine (Exparel®)
Cedars-Sinai Medical Center
NCT03723447
Validation of CapsoVision CapsoCam® SV-3 Capsule Endoscopy System
Capso Vision
NCT04573959
Pneumococcal Vaccination in Patients With Inflammatory Bowel Disease
Cedars-Sinai Medical Center
NCT00829595
A Randomized, Double-blind, Study to Explore the Effect of GED-0301 in Subjects With Active Crohn's Disease
Celgene
NCT02367183
Triple Combination Therapy in High Risk Crohn's Disease (CD)
Takeda
NCT02764762
A Comprehensive Self-Management Intervention for Individuals With Inflammatory Bowel Disease
University of Washington
NCT05651542
A Phase 2a Safety and Efficacy Open-Label Study of PRA023 in Subjects With Moderately to Severely Active Crohn's Disease
Prometheus Biosciences, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
NCT05013905
SMART-IBD App Trial
Children's Hospital Medical Center, Cincinnati
NCT06023667
Transcutaneous VNS to Treat Pediatric IBD
Northwell Health
NCT03863704
Digital Behavioral Interventions in Inflammatory Bowel Disease
Montefiore Medical Center
NCT04861597
Oral Administration of MB-102 Versus Dual Sugar Testing for Gut Permeability
MediBeacon
NCT03962998
Endoscopic Ultrasound (EUS) Guided Treatment With Humira for Crohn's Perianal Fistulas
Vanderbilt University Medical Center
NCT00517296
Effect of Grapes in Inflammatory Bowel Disease
Case Western Reserve University
NCT05972694
Anti-Inflammatory Effects of Mango Polyphenolics in Inflammatory Bowel Disease
Texas A&M University
NCT02227602
Fecal Microbiota Transplant (FMT) in Pediatric Active Ulcerative Colitis and Pediatric Active Crohn's Colitis
Stacy A. Kahn
NCT02330653
Analysis of Biologic Signatures in Crohn's Patients Undergoing Surgery
Weill Medical College of Cornell University
NCT06146335
FMT in Pediatric Crohn's Disease
Children's Hospital Los Angeles
NCT03194529
Flagyl Microbiome in Crohn's Disease
University of Louisville
NCT04682522
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 11 |
| Phase 2 | 9 |
| Phase 3 | 5 |
| Phase 4 | 8 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Crohn Disease Trial Landscape
72 indexed Crohn Disease studies · 34 recruiting (47%).
Phase mix: 13 late (III/IV) vs 20 early (I/II).
Top sponsor: Massachusetts General Hospital (6 trials), 9 others listed. 22 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Crohn Disease?
PlainTrial tracks 72 US clinical trials for Crohn Disease, of which 34 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Crohn Disease?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.