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ClinicalTrials.gov 34 recruiting now official registry

Crohn Disease clinical trials

34 of 72 indexed Crohn Disease trials are currently recruiting.

72 US clinical trials · 34 currently recruiting

Crohn Disease is the subject of 72 registered US clinical trials on ClinicalTrials.gov, 34 of them currently open to new participants. 13 are in Phase 3-4 (later-stage) and 20 in Phase 1-2 (earlier-stage). The most active sponsor is Massachusetts General Hospital, running 6 of these trials.

The research picture

Crohn Disease has 72 registered US clinical trials, 34 of them open to new participants right now, about 47% of the total.

34
recruiting participants now
47%
of trials open to enrollment
13
in Phase 3–4 (later-stage)
6
top sponsor: Massachusetts General Hospital
Phase 111Phase 29Phase 35Phase 48

Active & Recent Trials

72 total, page 2 of 2

COMPLETED Phase 3 386 participants

Safety and Efficacy of Adalimumab Versus Ustekinumab for One Year

Janssen Scientific Affairs

NCT03464136

COMPLETED Phase 2 290 participants

A Study to Test the Effect of TEV-48574 in Moderate to Severe Ulcerative Colitis or Crohn's Disease

Teva Branded Pharmaceutical Products R&D

NCT05499130

COMPLETED NA 187 participants

Clinical Study Comparing PillCam® Crohn's Capsule Endoscopy to Ileocolonoscopy (IC) Plus MRE for Detection of Active CD in the Small Bowel and Colon in Subjects With Known CD and Mucosal Disease.

Medtronic - MITG

NCT03241368

COMPLETED Phase 3 147 participants

BI 695501 Versus Humira in Patients With Active Crohn's Disease: a Trial Comparing Efficacy, Endoscopic Improvement, Safety, and Immunogenicity

Boehringer Ingelheim

NCT02871635

COMPLETED Phase 4 102 participants

Intraoperative TAP Block With Bupivacaine/Dexamethasone Against Liposomal Bupivacaine (Exparel®)

Cedars-Sinai Medical Center

NCT03723447

COMPLETED NA 84 participants

Validation of CapsoVision CapsoCam® SV-3 Capsule Endoscopy System

Capso Vision

NCT04573959

COMPLETED NA 69 participants

Pneumococcal Vaccination in Patients With Inflammatory Bowel Disease

Cedars-Sinai Medical Center

NCT00829595

COMPLETED Phase 1 64 participants

A Randomized, Double-blind, Study to Explore the Effect of GED-0301 in Subjects With Active Crohn's Disease

Celgene

NCT02367183

COMPLETED Phase 4 55 participants

Triple Combination Therapy in High Risk Crohn's Disease (CD)

Takeda

NCT02764762

COMPLETED NA 55 participants

A Comprehensive Self-Management Intervention for Individuals With Inflammatory Bowel Disease

University of Washington

NCT05651542

COMPLETED Phase 2 55 participants

A Phase 2a Safety and Efficacy Open-Label Study of PRA023 in Subjects With Moderately to Severely Active Crohn's Disease

Prometheus Biosciences, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)

NCT05013905

COMPLETED NA 45 participants

SMART-IBD App Trial

Children's Hospital Medical Center, Cincinnati

NCT06023667

COMPLETED NA 30 participants

Transcutaneous VNS to Treat Pediatric IBD

Northwell Health

NCT03863704

COMPLETED NA 30 participants

Digital Behavioral Interventions in Inflammatory Bowel Disease

Montefiore Medical Center

NCT04861597

COMPLETED Early Phase 1 22 participants

Oral Administration of MB-102 Versus Dual Sugar Testing for Gut Permeability

MediBeacon

NCT03962998

COMPLETED Phase 4 21 participants

Endoscopic Ultrasound (EUS) Guided Treatment With Humira for Crohn's Perianal Fistulas

Vanderbilt University Medical Center

NCT00517296

COMPLETED NA 21 participants

Effect of Grapes in Inflammatory Bowel Disease

Case Western Reserve University

NCT05972694

COMPLETED NA 20 participants

Anti-Inflammatory Effects of Mango Polyphenolics in Inflammatory Bowel Disease

Texas A&M University

NCT02227602

COMPLETED Phase 1 15 participants

Fecal Microbiota Transplant (FMT) in Pediatric Active Ulcerative Colitis and Pediatric Active Crohn's Colitis

Stacy A. Kahn

NCT02330653

COMPLETED NA 11 participants

Analysis of Biologic Signatures in Crohn's Patients Undergoing Surgery

Weill Medical College of Cornell University

NCT06146335

COMPLETED Phase 1 9 participants

FMT in Pediatric Crohn's Disease

Children's Hospital Los Angeles

NCT03194529

COMPLETED Phase 4 4 participants

Flagyl Microbiome in Crohn's Disease

University of Louisville

NCT04682522

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Phase Distribution

PhaseTrial count
Phase 1 11
Phase 2 9
Phase 3 5
Phase 4 8

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Crohn Disease Trial Landscape

72 indexed Crohn Disease studies · 34 recruiting (47%).

Phase mix: 13 late (III/IV) vs 20 early (I/II).

Top sponsor: Massachusetts General Hospital (6 trials), 9 others listed. 22 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Crohn Disease?

PlainTrial tracks 72 US clinical trials for Crohn Disease, of which 34 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Crohn Disease?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.