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ClinicalTrials.gov 6 recruiting now official registry

Melanoma (Skin) clinical trials

Every US clinical trial registered for Melanoma (Skin) — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.

53 US clinical trials · 6 currently recruiting

The research picture

Melanoma (Skin) has 53 registered US clinical trials, 6 of them open to new participants right now — about 11% of the total.

6
recruiting participants now
11%
of trials open to enrollment
1
in Phase 3–4 (later-stage)
10
top sponsor: National Cancer Institute (NCI)

Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.

Active & Recent Trials

RECRUITING NA 843 participants

Rural Adult and Youth Sun Protection Study

University of Utah

NCT06439979

RECRUITING 400 participants

Identification of Metabolic Phenotypes Associated With Melanoma Metastasis

University of Texas Southwestern Medical Center

NCT06400550

RECRUITING Phase 1 180 participants

A Phase 1/2 Clinical Trial to Assess the Safety, Tolerability, Pharmacokinetics and Preliminary Efficacy of HMBD-501 in Patients With HER3-Expressing Solid Tumors

Hummingbird Bioscience

NCT06956690

RECRUITING NA 40 participants

High-Intensity Exercise and High-Fiber Diet for Immunotherapy Outcomes in Melanoma Patients: The DUO Trial

Dana-Farber Cancer Institute

NCT06298734

RECRUITING Phase 2 30 participants

Phase II Study of Nivolumab in Combination With Relatlimab in Patients With Active Melanoma Brain Metastases

M.D. Anderson Cancer Center

NCT05704647

RECRUITING Phase 2 14 participants

Metronomic Cyclophosphamide With Pembrolizumab in Checkpoint Inhibitor Refractory Melanoma

University of California, Irvine

NCT06771544

ACTIVE NOT RECRUITING Phase 3 1,150 participants

High-Dose Interferon Alfa in Treating Patients With Stage II or Stage III Melanoma

ECOG-ACRIN Cancer Research Group

NCT00003641

ACTIVE NOT RECRUITING Early Phase 1 14 participants

Adaptive BRAF-MEK Inhibitor Therapy for Advanced BRAF Mutant Melanoma

H. Lee Moffitt Cancer Center and Research Institute

NCT03543969

COMPLETED Phase 2 179 participants

Monoclonal Antibody With or Without gp100 Peptides Plus Montanide ISA-51 in Treating Patients With Stage IV Melanoma

National Institutes of Health Clinical Center (CC)

NCT00077532

COMPLETED Phase 1 170 participants

Vaccine Therapy With or Without Cyclophosphamide in Treating Patients Who Have Undergone Surgery for Stage II, Stage III, or Stage IV Melanoma

Craig L Slingluff, Jr

NCT00118274

COMPLETED Phase 1 127 participants

Multiple Class I Peptides & Montanide ISA 51 VG w Escalating Doses of Anti-PD-1 ab BMS936558

H. Lee Moffitt Cancer Center and Research Institute

NCT01176461

COMPLETED Phase 2 77 participants

SWOG-9430: Surgery in Treating Patients With Metastatic Melanoma

SWOG Cancer Research Network

NCT00002860

COMPLETED Phase 2 60 participants

Vaccine Therapy and Interleukin-12 With Either Alum or Sargramostim After Surgery in Treating Patients With Melanoma

University of Southern California

NCT00031733

COMPLETED Phase 1 44 participants

PI-88 in Treating Patients With an Advanced Malignancy (Cancer) or Stage IV Melanoma

Cellxpert Biotechnology

NCT00073892

COMPLETED Phase 2 41 participants

Metabolomic and Inflammatory Effects of Oral Aspirin (ASA) in Subjects at Risk for Melanoma

University of Utah

NCT04062032

COMPLETED Phase 1 40 participants

Inhaled Sargramostim in Treating Patients With Melanoma Metastatic to the Lung

Alliance for Clinical Trials in Oncology

NCT00017121

COMPLETED Phase 2 35 participants

Isolated Limb Infusion of Chemotherapy in Treating Patients With Melanoma or Soft Tissue Sarcoma of the Arm or Leg That Cannot Be Removed By Surgery

Memorial Sloan Kettering Cancer Center

NCT00004250

COMPLETED Phase 1 35 participants

Vaccine Therapy in Treating Patients With Stage IIB, Stage IIC, Stage III, or Stage IV Melanoma

Memorial Sloan Kettering Cancer Center

NCT00398073

COMPLETED Phase 2 32 participants

Ticilimumab (CP-675,206) in Treating Patients With Stage IIIC or Stage IV Melanoma

Jonsson Comprehensive Cancer Center

NCT00471887

COMPLETED Phase 1 22 participants

Vaccine Therapy in Treating Patients With Metastatic Melanoma

University of Virginia

NCT00003224

COMPLETED Phase 1 22 participants

Vaccine Therapy in Treating Patients With Stage III or Stage IV Melanoma

Pawel Kalinski

NCT00390338

COMPLETED Phase 2 20 participants

Cyclophosphamide, Fludarabine, and High-Dose Interleukin-2 in Treating Patients With Metastatic Melanoma

Dartmouth-Hitchcock Medical Center

NCT00085423

COMPLETED Phase 1 20 participants

Biological Therapy in Treating Patients With Metastatic Melanoma

Fred Hutchinson Cancer Center

NCT00002786

COMPLETED Phase 1 20 participants

Vaccine Therapy and Interleukin-12 in Treating Patients With Metastatic Melanoma

University of Chicago

NCT00002952

COMPLETED Phase 1 20 participants

Sorafenib and Isolated Limb Infusion of Melphalan in Treating Patients With Stage III Melanoma of the Arm or Leg

Duke University

NCT00565968

COMPLETED Early Phase 1 20 participants

Hydroxychloroquine in Patients With Stage III or Stage IV Melanoma That Can Be Removed by Surgery

Rutgers, The State University of New Jersey

NCT00962845

COMPLETED Phase 1 19 participants

Vaccine Therapy in Treating Patients With Stage IIB, Stage IIC, Stage III, or Stage IV Melanoma

Memorial Sloan Kettering Cancer Center

NCT00104845

COMPLETED Phase 1 15 participants

Vaccine Therapy in Treating Patients With Melanoma

National Cancer Institute (NCI)

NCT00003556

COMPLETED Early Phase 1 15 participants

Genistein and Interleukin-2 in Treating Patients With Metastatic Melanoma or Kidney Cancer

Northwestern University

NCT00276835

COMPLETED Phase 1 11 participants

Imiquimod and Laser Therapy With or Without a Green Dye in Treating Patients With Stage III or Stage IV Melanoma That Has Spread to Other Parts of the Skin

University of Oklahoma

NCT00453050

COMPLETED Phase 2

Pyrazoloacridine in Treating Patients With Metastatic Skin or Eye Melanoma

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

NCT00003802

COMPLETED Phase 2

Radiation Therapy in Treating Patients With Newly Diagnosed Brain Metastases From Kidney Cancer, Melanoma, or Sarcoma

Eastern Cooperative Oncology Group

NCT00003308

COMPLETED Phase 2

Lymphocyte-Depleting Nonmyeloablative Preparative Chemotherapy Followed By Autologous Lymphocyte Infusion, Peptide Vaccine Plus Montanide ISA-51, and Interleukin-2 in Treating Patients With Metastatic Melanoma

National Cancer Institute (NCI)

NCT00079144

COMPLETED Phase 2

Vaccine Therapy in Treating Patients With Stage IV Melanoma

SWOG Cancer Research Network

NCT00042783

COMPLETED Phase 2

Vaccine Therapy in Treating Patients With Metastatic Cancer

National Cancer Institute (NCI)

NCT00021164

COMPLETED Phase 2

Immunization With gp100 Protein Vaccine in Treating Patients With Metastatic Melanoma

National Cancer Institute (NCI)

NCT00072085

COMPLETED Phase 2

Vaccine Therapy in Treating Patients With Metastatic Melanoma

National Cancer Institute (NCI)

NCT00019994

COMPLETED Phase 2

Combination Chemotherapy, Total-Body Irradiation, Peripheral Stem Cell Transplantation, and Lymphocyte Infusion in Treating Patients With Stage IV Melanoma

Fred Hutchinson Cancer Center

NCT00006233

COMPLETED Phase 1

Biological Therapy in Treating Patients With Metastatic Melanoma or Metastatic Kidney Cancer

National Cancer Institute (NCI)

NCT00020540

COMPLETED Phase 2

Vaccine Therapy With or Without Interleukin-2 in Treating Patients With Metastatic Melanoma That Has Not Responded to Previous Treatment

National Cancer Institute (NCI)

NCT00022438

COMPLETED Phase 1

Gene Therapy and Ganciclovir in Treating Patients With Stage IV Melanoma

National Human Genome Research Institute (NHGRI)

NCT00005057

COMPLETED Phase 1

Vaccine Therapy With or Without Interleukin-2 in Treating Patients With Recurrent Metastatic Melanoma

National Cancer Institute (NCI)

NCT00019175

COMPLETED Phase 1

Vaccine Therapy in Treating Patients With Stage III or Stage IV Melanoma

Memorial Sloan Kettering Cancer Center

NCT00005633

COMPLETED Phase 1

Biological Therapy in Treating Patients With Metastatic Melanoma

Fred Hutchinson Cancer Center

NCT00045149

COMPLETED Phase 2

Vaccine Therapy With or Without Biological Therapy in Treating Patients With Metastatic Melanoma

Eastern Cooperative Oncology Group

NCT00006385

COMPLETED Phase 1

Gene Therapy in Treating Patients With Metastatic Melanoma

University of Colorado, Denver

NCT00005943

COMPLETED Phase 2

Irofulven in Treating Patients With Stage IV Melanoma

University of Colorado, Denver

NCT00005968

COMPLETED Phase 1

Vaccine Therapy in Treating Patients With Metastatic Melanoma Who Are Undergoing Surgery for Lymph Node and Tumor Removal

Duke University

NCT00003229

COMPLETED Phase 2

Vaccine Therapy in Treating Patients With Melanoma

National Cancer Institute (NCI)

NCT00020358

COMPLETED Phase 2

Indomethacin Plus Biological Therapy in Treating Patients With Advanced Melanoma

St. Luke's Medical Center

NCT00002535

COMPLETED Phase 1

Interferon Gamma in Treating Patients With Recurrent or Metastatic Melanoma or Other Solid Tumors

University of Rochester

NCT00004016

COMPLETED Phase 1

Temozolomide and Thalidomide in Treating Patients With Stage III or Stage IV Melanoma

Memorial Sloan Kettering Cancer Center

NCT00005815

COMPLETED Phase 1

Interleukin-7 and Vaccine Therapy in Treating Patients With Metastatic Melanoma

National Cancer Institute (NCI)

NCT00091338

Phase Distribution

PhaseTrial count
Phase 1 27
Phase 2 22
Phase 3 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Melanoma (Skin) Trial Landscape

ClinicalTrials.gov lists 53 US studies indexed under Melanoma (Skin), and 6 of those are currently open to recruitment — roughly 11% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Melanoma (Skin) shows 1 late-stage studies (Phase 3 and Phase 4 combined) alongside 49 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Melanoma (Skin) is led by National Cancer Institute (NCI) with 10 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 53 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Melanoma (Skin)?

PlainTrial tracks 53 US clinical trials for Melanoma (Skin), of which 6 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Melanoma (Skin)?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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