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Melanoma (Skin) clinical trials
Every US clinical trial registered for Melanoma (Skin) — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.
53 US clinical trials · 6 currently recruiting
The research picture
Melanoma (Skin) has 53 registered US clinical trials, 6 of them open to new participants right now — about 11% of the total.
- 6
- recruiting participants now
- 11%
- of trials open to enrollment
- 1
- in Phase 3–4 (later-stage)
- 10
- top sponsor: National Cancer Institute (NCI)
Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.
Active & Recent Trials
Rural Adult and Youth Sun Protection Study
University of Utah
NCT06439979
Identification of Metabolic Phenotypes Associated With Melanoma Metastasis
University of Texas Southwestern Medical Center
NCT06400550
A Phase 1/2 Clinical Trial to Assess the Safety, Tolerability, Pharmacokinetics and Preliminary Efficacy of HMBD-501 in Patients With HER3-Expressing Solid Tumors
Hummingbird Bioscience
NCT06956690
High-Intensity Exercise and High-Fiber Diet for Immunotherapy Outcomes in Melanoma Patients: The DUO Trial
Dana-Farber Cancer Institute
NCT06298734
Phase II Study of Nivolumab in Combination With Relatlimab in Patients With Active Melanoma Brain Metastases
M.D. Anderson Cancer Center
NCT05704647
Metronomic Cyclophosphamide With Pembrolizumab in Checkpoint Inhibitor Refractory Melanoma
University of California, Irvine
NCT06771544
High-Dose Interferon Alfa in Treating Patients With Stage II or Stage III Melanoma
ECOG-ACRIN Cancer Research Group
NCT00003641
Adaptive BRAF-MEK Inhibitor Therapy for Advanced BRAF Mutant Melanoma
H. Lee Moffitt Cancer Center and Research Institute
NCT03543969
Monoclonal Antibody With or Without gp100 Peptides Plus Montanide ISA-51 in Treating Patients With Stage IV Melanoma
National Institutes of Health Clinical Center (CC)
NCT00077532
Vaccine Therapy With or Without Cyclophosphamide in Treating Patients Who Have Undergone Surgery for Stage II, Stage III, or Stage IV Melanoma
Craig L Slingluff, Jr
NCT00118274
Multiple Class I Peptides & Montanide ISA 51 VG w Escalating Doses of Anti-PD-1 ab BMS936558
H. Lee Moffitt Cancer Center and Research Institute
NCT01176461
SWOG-9430: Surgery in Treating Patients With Metastatic Melanoma
SWOG Cancer Research Network
NCT00002860
Vaccine Therapy and Interleukin-12 With Either Alum or Sargramostim After Surgery in Treating Patients With Melanoma
University of Southern California
NCT00031733
PI-88 in Treating Patients With an Advanced Malignancy (Cancer) or Stage IV Melanoma
Cellxpert Biotechnology
NCT00073892
Metabolomic and Inflammatory Effects of Oral Aspirin (ASA) in Subjects at Risk for Melanoma
University of Utah
NCT04062032
Inhaled Sargramostim in Treating Patients With Melanoma Metastatic to the Lung
Alliance for Clinical Trials in Oncology
NCT00017121
Isolated Limb Infusion of Chemotherapy in Treating Patients With Melanoma or Soft Tissue Sarcoma of the Arm or Leg That Cannot Be Removed By Surgery
Memorial Sloan Kettering Cancer Center
NCT00004250
Vaccine Therapy in Treating Patients With Stage IIB, Stage IIC, Stage III, or Stage IV Melanoma
Memorial Sloan Kettering Cancer Center
NCT00398073
Ticilimumab (CP-675,206) in Treating Patients With Stage IIIC or Stage IV Melanoma
Jonsson Comprehensive Cancer Center
NCT00471887
Vaccine Therapy in Treating Patients With Metastatic Melanoma
University of Virginia
NCT00003224
Vaccine Therapy in Treating Patients With Stage III or Stage IV Melanoma
Pawel Kalinski
NCT00390338
Cyclophosphamide, Fludarabine, and High-Dose Interleukin-2 in Treating Patients With Metastatic Melanoma
Dartmouth-Hitchcock Medical Center
NCT00085423
Biological Therapy in Treating Patients With Metastatic Melanoma
Fred Hutchinson Cancer Center
NCT00002786
Vaccine Therapy and Interleukin-12 in Treating Patients With Metastatic Melanoma
University of Chicago
NCT00002952
Sorafenib and Isolated Limb Infusion of Melphalan in Treating Patients With Stage III Melanoma of the Arm or Leg
Duke University
NCT00565968
Hydroxychloroquine in Patients With Stage III or Stage IV Melanoma That Can Be Removed by Surgery
Rutgers, The State University of New Jersey
NCT00962845
Vaccine Therapy in Treating Patients With Stage IIB, Stage IIC, Stage III, or Stage IV Melanoma
Memorial Sloan Kettering Cancer Center
NCT00104845
Vaccine Therapy in Treating Patients With Melanoma
National Cancer Institute (NCI)
NCT00003556
Genistein and Interleukin-2 in Treating Patients With Metastatic Melanoma or Kidney Cancer
Northwestern University
NCT00276835
Imiquimod and Laser Therapy With or Without a Green Dye in Treating Patients With Stage III or Stage IV Melanoma That Has Spread to Other Parts of the Skin
University of Oklahoma
NCT00453050
Pyrazoloacridine in Treating Patients With Metastatic Skin or Eye Melanoma
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
NCT00003802
Radiation Therapy in Treating Patients With Newly Diagnosed Brain Metastases From Kidney Cancer, Melanoma, or Sarcoma
Eastern Cooperative Oncology Group
NCT00003308
Lymphocyte-Depleting Nonmyeloablative Preparative Chemotherapy Followed By Autologous Lymphocyte Infusion, Peptide Vaccine Plus Montanide ISA-51, and Interleukin-2 in Treating Patients With Metastatic Melanoma
National Cancer Institute (NCI)
NCT00079144
Vaccine Therapy in Treating Patients With Stage IV Melanoma
SWOG Cancer Research Network
NCT00042783
Vaccine Therapy in Treating Patients With Metastatic Cancer
National Cancer Institute (NCI)
NCT00021164
Immunization With gp100 Protein Vaccine in Treating Patients With Metastatic Melanoma
National Cancer Institute (NCI)
NCT00072085
Vaccine Therapy in Treating Patients With Metastatic Melanoma
National Cancer Institute (NCI)
NCT00019994
Combination Chemotherapy, Total-Body Irradiation, Peripheral Stem Cell Transplantation, and Lymphocyte Infusion in Treating Patients With Stage IV Melanoma
Fred Hutchinson Cancer Center
NCT00006233
Biological Therapy in Treating Patients With Metastatic Melanoma or Metastatic Kidney Cancer
National Cancer Institute (NCI)
NCT00020540
Vaccine Therapy With or Without Interleukin-2 in Treating Patients With Metastatic Melanoma That Has Not Responded to Previous Treatment
National Cancer Institute (NCI)
NCT00022438
Gene Therapy and Ganciclovir in Treating Patients With Stage IV Melanoma
National Human Genome Research Institute (NHGRI)
NCT00005057
Vaccine Therapy With or Without Interleukin-2 in Treating Patients With Recurrent Metastatic Melanoma
National Cancer Institute (NCI)
NCT00019175
Vaccine Therapy in Treating Patients With Stage III or Stage IV Melanoma
Memorial Sloan Kettering Cancer Center
NCT00005633
Biological Therapy in Treating Patients With Metastatic Melanoma
Fred Hutchinson Cancer Center
NCT00045149
Vaccine Therapy With or Without Biological Therapy in Treating Patients With Metastatic Melanoma
Eastern Cooperative Oncology Group
NCT00006385
Gene Therapy in Treating Patients With Metastatic Melanoma
University of Colorado, Denver
NCT00005943
Irofulven in Treating Patients With Stage IV Melanoma
University of Colorado, Denver
NCT00005968
Vaccine Therapy in Treating Patients With Metastatic Melanoma Who Are Undergoing Surgery for Lymph Node and Tumor Removal
Duke University
NCT00003229
Vaccine Therapy in Treating Patients With Melanoma
National Cancer Institute (NCI)
NCT00020358
Indomethacin Plus Biological Therapy in Treating Patients With Advanced Melanoma
St. Luke's Medical Center
NCT00002535
Interferon Gamma in Treating Patients With Recurrent or Metastatic Melanoma or Other Solid Tumors
University of Rochester
NCT00004016
Temozolomide and Thalidomide in Treating Patients With Stage III or Stage IV Melanoma
Memorial Sloan Kettering Cancer Center
NCT00005815
Interleukin-7 and Vaccine Therapy in Treating Patients With Metastatic Melanoma
National Cancer Institute (NCI)
NCT00091338
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 27 |
| Phase 2 | 22 |
| Phase 3 | 1 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Melanoma (Skin) Trial Landscape
ClinicalTrials.gov lists 53 US studies indexed under Melanoma (Skin), and 6 of those are currently open to recruitment — roughly 11% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
The phase distribution for Melanoma (Skin) shows 1 late-stage studies (Phase 3 and Phase 4 combined) alongside 49 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
Top sponsor activity for Melanoma (Skin) is led by National Cancer Institute (NCI) with 10 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 53 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Melanoma (Skin)?
PlainTrial tracks 53 US clinical trials for Melanoma (Skin), of which 6 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Melanoma (Skin)?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology — how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.