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NCT02465060 · ClinicalTrials.gov registry record · Phase 2
Targeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors, Lymphomas, or Multiple Myeloma (The MATCH Screening Trial)
A Phase 2 study of Advanced Malignant Solid Neoplasm and Breast Carcinoma, sponsored by National Cancer Institute (NCI).
- Active
- Registry status
- Phase 2
- Development phase
- 6,452
- Enrollment target
- 20
- Study locations
NCT02465060 is a Phase 2 study of Advanced Malignant Solid Neoplasm and Breast Carcinoma that is active but no longer recruiting, run by National Cancer Institute (NCI). The registered enrollment target is 6,452 participants, above the 117-participant average among 108 other Advanced Malignant Solid Neoplasm trials with a reported enrollment target (5415% higher). The trial reports 20 study locations across 3 states.
The verdict
NCT02465060, a Phase 2 study of Advanced Malignant Solid Neoplasm and Breast Carcinoma, is active but no longer recruiting, sponsored by National Cancer Institute (NCI).
- ACTIVE NOT RECRUITING
- Registry status
- Phase 2
- Development phase
- 6,452 participants
- Enrollment target
- 20
- Study locations
Study Summary
This phase II MATCH screening and multi-sub-trial studies how well treatment that is directed by genetic testing works in patients with solid tumors, lymphomas, or multiple myelomas that may have spread from where it first started to nearby tissue, lymph nodes, or distant parts of the body (advanced) and does not respond to treatment (refractory). Patients must have progressed following at least one line of standard treatment or for which no agreed upon treatment approach exists. Genetic tests look at the unique genetic material (genes) of patients' tumor cells. Patients with genetic abnormalities (such as mutations, amplifications, or translocations) may benefit more from treatment which targets their tumor's particular genetic abnormality. Identifying these genetic abnormalities first may help doctors plan better treatment for patients with solid tumors, lymphomas, or multiple myeloma.
Conditions Studied
Interventions
- PROCEDURE Biopsy Procedure
- DRUG Afatinib
- DRUG Binimetinib
- DRUG Afatinib Dimaleate
- DRUG Adavosertib
Study Locations (20)
Alaska
- Anchorage Associates in Radiation Medicine - Anchorage
- Anchorage Radiation Therapy Center - Anchorage
- Alaska Breast Care and Surgery LLC - Anchorage
- Alaska Oncology and Hematology LLC - Anchorage
- Alaska Regional Hospital - Anchorage
- Alaska Women's Cancer Care - Anchorage
- Anchorage Oncology Centre - Anchorage
- Katmai Oncology Group - Anchorage
- Providence Alaska Medical Center - Anchorage
- Fairbanks Memorial Hospital - Fairbanks
Arizona
- CTCA at Western Regional Medical Center - Goodyear
- Kingman Regional Medical Center - Kingman
- Cancer Center at Saint Joseph's - Phoenix
- Saint Joseph's Hospital and Medical Center - Phoenix
- Mayo Clinic Hospital in Arizona - Phoenix
- Mayo Clinic in Arizona - Scottsdale
Alabama
- University of Alabama at Birmingham Cancer Center - Birmingham
- Thomas Hospital - Fairhope
- Mobile Infirmary Medical Center - Mobile
- University of South Alabama Mitchell Cancer Institute - Mobile
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 6,452 participants |
| Start Date | 2015-08-17 |
| Est. Completion | 2026-12-31 |
| Phase | Phase 2 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT02465060
The ClinicalTrials.gov registry entry for NCT02465060 describes a study currently listed as active not recruiting, categorized as Phase 2. The registered enrollment target is 6,452 participants, a figure that helps gauge the scale of data the investigators plan to collect, above the 117-participant average among 108 other Advanced Malignant Solid Neoplasm trials with a reported enrollment target (5415% higher). The listed sponsor is National Cancer Institute (NCI), which has 3,257 total studies on file at ClinicalTrials.gov.
The record links to 10 conditions, with Advanced Malignant Solid Neoplasm appearing as the primary indexed condition, and to 5 interventions - of which Biopsy Procedure is the first listed.
NCT02465060 reports 20 study locations spanning 3 distinct geographic areas - top geographies include Alaska, Arizona, Alabama.
Frequently Asked Questions
What is clinical trial NCT02465060 about?
NCT02465060 is a clinical study titled "Targeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors, Lymphomas, or Multiple Myeloma (The MATCH Screening Trial)". This phase II MATCH screening and multi-sub-trial studies how well treatment that is directed by genetic testing works in patients with solid tumors, lymphomas, or multiple myelomas that may have spread from where it first started to nearby tissue, lymph nodes, or distant parts of the body (advanced...
What is the current status of trial NCT02465060?
This trial is currently active not recruiting. It is a Phase 2 study. The enrollment target is 6,452 participants. The study started on 2015-08-17. Estimated completion is 2026-12-31.
What conditions does trial NCT02465060 study?
This clinical trial studies the following conditions: Advanced Malignant Solid Neoplasm, Breast Carcinoma, Colorectal Carcinoma, Advanced Lymphoma, Endometrial Carcinoma.
What interventions are being tested in trial NCT02465060?
The interventions under investigation include: Biopsy Procedure (PROCEDURE), Afatinib (DRUG), Binimetinib (DRUG), Afatinib Dimaleate (DRUG), Adavosertib (DRUG).
Who is sponsoring clinical trial NCT02465060?
This trial is sponsored by National Cancer Institute (NCI), which has 3,257 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT02465060 being conducted?
This trial has 20 study locations across Alabama, Alaska, Arizona. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.