MacroGenics
MacroGenics sponsors 36 registered US clinical trials on ClinicalTrials.gov, 4 of them currently recruiting, and 21 completed. 2 of these trials are in Phase 3-4 (later-stage) and 33 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Colorectal Carcinoma, with 2 trials.
Trial Pipeline
36 total, page 1 of 1
A Study of Lorigerlimab in Participants With Advanced Solid Tumors
NCT06730347
A Study of MGC028 in Participants With Advanced Solid Tumors
NCT06723236
A Study of MGC026 in Participants With Advanced Solid Tumors
NCT06242470
A Study of MGD024 in Patients With Relapsed or Refractory Hematologic Malignancies
NCT05362773
A Study of Lorigerlimab With Docetaxel or Docetaxel Alone in Participants With Metastatic Castration-Resistant Prostate Cancer
NCT05848011
A Study of Vobramitamab Duocarmazine in Participants With Metastatic Castration Resistant Prostate Cancer and Other Solid Tumors
NCT05551117
A Study of MGD020 Alone or Combined With MGD014 in Persons With HIV-1 on Antiretroviral Therapy
NCT05261191
A Study of MGC018 in Combination With MGD019 in Participants With Advanced Solid Tumors
NCT05293496
Enoblituzumab Plus Retifanlimab or Tebotelimab in Head and Neck Cancer
NCT04634825
Combination Margetuximab, Retifanlimab, Tebotelimab, and Chemotherapy Phase 2/3 Trial in HER2+ Gastric/GEJ Cancer
NCT04082364
MGD019 DART® Protein in Unresectable/Metastatic Cancer
NCT03761017
MGC018 With or Without MGA012 in Advanced Solid Tumors
NCT03729596
MGD014 in HIV-Infected Individuals on Suppressive Antiretroviral Therapy
NCT03570918
MGD007 Combined With MGA012 in Relapsed/Refractory Metastatic Colorectal Cancer
NCT03531632
MGD009/MGA012 Combination in Relapsed/Refractory Cancer
NCT03406949
A Study of MGD013 in Patients With Unresectable or Metastatic Neoplasms
NCT03219268
Enoblituzumab (MGA271) in Children With B7-H3-expressing Solid Tumors
NCT02982941
Combination Margetuximab and Pembrolizumab for Advanced, Metastatic HER2(+) Gastric or Gastroesophageal Junction Cancer
NCT02689284
Safety Study of MGD009 in B7-H3-expressing Tumors
NCT02628535
Margetuximab Plus Chemotherapy vs Trastuzumab Plus Chemotherapy in the Treatment of HER2+ Metastatic Breast Cancer
NCT02492711
Safety Study of Enoblituzumab (MGA271) in Combination With Pembrolizumab or MGA012 in Refractory Cancer
NCT02475213
Safety Study of Enoblituzumab (MGA271) in Combination With Ipilimumab in Refractory Cancer
NCT02381314
Phase 1 Study of MGD010 in Healthy Subjects
NCT02376036
Phase 1 Study of MGD007 in Relapsed/Refractory Metastatic Colorectal Carcinoma
NCT02248805
Flotetuzumab in Primary Induction Failure (PIF) or Early Relapse (ER) Acute Myeloid Leukemia (AML)
NCT02152956
Tissue Procurement Substudy for Participants in Study CP-MGA271-01
NCT01918930
Phase 2 Study of the Monoclonal Antibody MGAH22 (Margetuximab) in Patients With Relapsed or Refractory Advanced Breast Cancer
NCT01828021
Safety Study of MGA271 in Refractory Cancer
NCT01391143
Safety Study of MGAH22 in HER2-positive Carcinomas
NCT01148849
Safety Study of the Monoclonal Antibody Teplizumab (MGA031) in Subjects With Moderate or More Severe Psoriasis
NCT00954915
Protege Encore Study- Clinical Trial of Teplizumab (MGA031) in Children and Adults With Recent-Onset Type 1 Diabetes Mellitus
NCT00920582
Protege Extension Trial - Long Term Follow Up Trial for Subjects Who Completed the Protege Study (CP-MGA031-01)
NCT00870818
Monoclonal Antibody RAV12 and Gemcitabine in Treating Patients With Metastatic Pancreatic Cancer
NCT00625586
A Trial to Evaluate the Safety of a Single Intravenous Infusion of MGAWN1 in Healthy Adults
NCT00515385
The Protégé Study - Clinical Trial of MGA031 in Children and Adults With Recent-Onset Type 1 Diabetes Mellitus
NCT00385697
RAV12 in Treating Patients With Metastatic or Recurrent Adenocarcinoma
NCT00101972
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 25 |
| Phase 2 | 8 |
| Phase 3 | 2 |
Therapeutic Areas
What the Pipeline for MacroGenics Shows
According to the ClinicalTrials.gov registry, MacroGenics is linked to 36 US clinical trials across every stage of research activity. Of those, 4 studies are currently recruiting, about 11% of the sponsor's indexed portfolio, and 21 are already marked complete, representing roughly 58% of the total.
The phase mix for MacroGenics reports 2 late-stage studies (Phase 3 and Phase 4 combined) and 33 earlier-phase studies (Phase 1 and Phase 2).
The top therapeutic focus area indexed for MacroGenics is Colorectal Carcinoma with 2 linked trials, and 9 other condition areas appear in the top list above.
How to read these pipeline numbers
Recruiting share is one of the more practical signals here: it reflects how much of a sponsor's research is presently open to new participants, while the completed share indicates the depth of finished work that has already contributed registry results. Both counts come directly from the public ClinicalTrials.gov dataset and are refreshed on the registry side; this page mirrors the latest data pull without altering it.
A portfolio weighted toward Phase 3 usually reflects an organization advancing candidates toward regulatory review, where the research centers on comparative efficacy and broader safety across larger populations. A heavier Phase 1 and Phase 2 tilt generally indicates exploratory work, safety, dosing, and early signal detection, and is common among research-forward sponsors that seed many early programs. Phase 4 entries, when present, track interventions already in real-world use and typically focus on long-term safety, effectiveness across subgroups, or formulation comparisons.
That distribution is a quick read of where the organization concentrates its research attention; it does not imply product availability, market share, or any clinical endorsement. All numbers on this page come from ClinicalTrials.gov maintained by the National Library of Medicine, and counts can shift as new studies are registered or existing ones update their status. This information is provided for reference and educational purposes only, not as medical, investment, or regulatory advice, verify current details directly with ClinicalTrials.gov before relying on any figure here.
Read our methodology - how this data is sourced, computed, and verified.
Related
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial from this sponsor, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.