MacroGenics

36 total trials 4 currently recruiting 21 completed

MacroGenics sponsors 36 registered US clinical trials on ClinicalTrials.gov, 4 of them currently recruiting, and 21 completed. 2 of these trials are in Phase 3-4 (later-stage) and 33 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Colorectal Carcinoma, with 2 trials.

Trial Pipeline

36 total, page 1 of 1

RECRUITING Phase 2

A Study of Lorigerlimab in Participants With Advanced Solid Tumors

NCT06730347

RECRUITING Phase 1

A Study of MGC028 in Participants With Advanced Solid Tumors

NCT06723236

RECRUITING Phase 1

A Study of MGC026 in Participants With Advanced Solid Tumors

NCT06242470

RECRUITING Phase 1

A Study of MGD024 in Patients With Relapsed or Refractory Hematologic Malignancies

NCT05362773

ACTIVE NOT RECRUITING Phase 2

A Study of Lorigerlimab With Docetaxel or Docetaxel Alone in Participants With Metastatic Castration-Resistant Prostate Cancer

NCT05848011

TERMINATED Phase 2

A Study of Vobramitamab Duocarmazine in Participants With Metastatic Castration Resistant Prostate Cancer and Other Solid Tumors

NCT05551117

COMPLETED Phase 1

A Study of MGD020 Alone or Combined With MGD014 in Persons With HIV-1 on Antiretroviral Therapy

NCT05261191

COMPLETED Phase 1

A Study of MGC018 in Combination With MGD019 in Participants With Advanced Solid Tumors

NCT05293496

TERMINATED Phase 2

Enoblituzumab Plus Retifanlimab or Tebotelimab in Head and Neck Cancer

NCT04634825

COMPLETED Phase 2

Combination Margetuximab, Retifanlimab, Tebotelimab, and Chemotherapy Phase 2/3 Trial in HER2+ Gastric/GEJ Cancer

NCT04082364

COMPLETED Phase 1

MGD019 DART® Protein in Unresectable/Metastatic Cancer

NCT03761017

TERMINATED Phase 1

MGC018 With or Without MGA012 in Advanced Solid Tumors

NCT03729596

COMPLETED Phase 1

MGD014 in HIV-Infected Individuals on Suppressive Antiretroviral Therapy

NCT03570918

COMPLETED Phase 1

MGD007 Combined With MGA012 in Relapsed/Refractory Metastatic Colorectal Cancer

NCT03531632

COMPLETED Phase 1

MGD009/MGA012 Combination in Relapsed/Refractory Cancer

NCT03406949

COMPLETED Phase 1

A Study of MGD013 in Patients With Unresectable or Metastatic Neoplasms

NCT03219268

COMPLETED Phase 1

Enoblituzumab (MGA271) in Children With B7-H3-expressing Solid Tumors

NCT02982941

COMPLETED Phase 1

Combination Margetuximab and Pembrolizumab for Advanced, Metastatic HER2(+) Gastric or Gastroesophageal Junction Cancer

NCT02689284

TERMINATED Phase 1

Safety Study of MGD009 in B7-H3-expressing Tumors

NCT02628535

COMPLETED Phase 3

Margetuximab Plus Chemotherapy vs Trastuzumab Plus Chemotherapy in the Treatment of HER2+ Metastatic Breast Cancer

NCT02492711

COMPLETED Phase 1

Safety Study of Enoblituzumab (MGA271) in Combination With Pembrolizumab or MGA012 in Refractory Cancer

NCT02475213

COMPLETED Phase 1

Safety Study of Enoblituzumab (MGA271) in Combination With Ipilimumab in Refractory Cancer

NCT02381314

COMPLETED Phase 1

Phase 1 Study of MGD010 in Healthy Subjects

NCT02376036

COMPLETED Phase 1

Phase 1 Study of MGD007 in Relapsed/Refractory Metastatic Colorectal Carcinoma

NCT02248805

TERMINATED Phase 1

Flotetuzumab in Primary Induction Failure (PIF) or Early Relapse (ER) Acute Myeloid Leukemia (AML)

NCT02152956

TERMINATED Phase 1

Tissue Procurement Substudy for Participants in Study CP-MGA271-01

NCT01918930

COMPLETED Phase 2

Phase 2 Study of the Monoclonal Antibody MGAH22 (Margetuximab) in Patients With Relapsed or Refractory Advanced Breast Cancer

NCT01828021

COMPLETED Phase 1

Safety Study of MGA271 in Refractory Cancer

NCT01391143

COMPLETED Phase 1

Safety Study of MGAH22 in HER2-positive Carcinomas

NCT01148849

TERMINATED Phase 1

Safety Study of the Monoclonal Antibody Teplizumab (MGA031) in Subjects With Moderate or More Severe Psoriasis

NCT00954915

TERMINATED Phase 3

Protege Encore Study- Clinical Trial of Teplizumab (MGA031) in Children and Adults With Recent-Onset Type 1 Diabetes Mellitus

NCT00920582

TERMINATED NA

Protege Extension Trial - Long Term Follow Up Trial for Subjects Who Completed the Protege Study (CP-MGA031-01)

NCT00870818

TERMINATED Phase 2

Monoclonal Antibody RAV12 and Gemcitabine in Treating Patients With Metastatic Pancreatic Cancer

NCT00625586

COMPLETED Phase 1

A Trial to Evaluate the Safety of a Single Intravenous Infusion of MGAWN1 in Healthy Adults

NCT00515385

COMPLETED Phase 2

The Protégé Study - Clinical Trial of MGA031 in Children and Adults With Recent-Onset Type 1 Diabetes Mellitus

NCT00385697

COMPLETED Phase 1

RAV12 in Treating Patients With Metastatic or Recurrent Adenocarcinoma

NCT00101972

What the Pipeline for MacroGenics Shows

According to the ClinicalTrials.gov registry, MacroGenics is linked to 36 US clinical trials across every stage of research activity. Of those, 4 studies are currently recruiting, about 11% of the sponsor's indexed portfolio, and 21 are already marked complete, representing roughly 58% of the total.

The phase mix for MacroGenics reports 2 late-stage studies (Phase 3 and Phase 4 combined) and 33 earlier-phase studies (Phase 1 and Phase 2).

The top therapeutic focus area indexed for MacroGenics is Colorectal Carcinoma with 2 linked trials, and 9 other condition areas appear in the top list above.

How to read these pipeline numbers

Recruiting share is one of the more practical signals here: it reflects how much of a sponsor's research is presently open to new participants, while the completed share indicates the depth of finished work that has already contributed registry results. Both counts come directly from the public ClinicalTrials.gov dataset and are refreshed on the registry side; this page mirrors the latest data pull without altering it.

A portfolio weighted toward Phase 3 usually reflects an organization advancing candidates toward regulatory review, where the research centers on comparative efficacy and broader safety across larger populations. A heavier Phase 1 and Phase 2 tilt generally indicates exploratory work, safety, dosing, and early signal detection, and is common among research-forward sponsors that seed many early programs. Phase 4 entries, when present, track interventions already in real-world use and typically focus on long-term safety, effectiveness across subgroups, or formulation comparisons.

That distribution is a quick read of where the organization concentrates its research attention; it does not imply product availability, market share, or any clinical endorsement. All numbers on this page come from ClinicalTrials.gov maintained by the National Library of Medicine, and counts can shift as new studies are registered or existing ones update their status. This information is provided for reference and educational purposes only, not as medical, investment, or regulatory advice, verify current details directly with ClinicalTrials.gov before relying on any figure here.

Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial from this sponsor, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.