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NCT06871111 · ClinicalTrials.gov registry record · Phase 1
The Microbiota Augmentation to Reestablish Commensal Organisms (MARCO) Trial
A Phase 1 study of Cirrhosis, Liver and Liver Diseases, sponsored by University of Chicago.
- Recruiting
- Registry status
- Phase 1
- Development phase
- 24
- Enrollment target
- 1
- Study location
NCT06871111: Recruiting Phase 1 study of Cirrhosis, Liver and Liver Diseases, sponsored by University of Chicago.
NCT06871111 is a Phase 1 study of Cirrhosis, Liver and Liver Diseases that is actively recruiting participants, run by University of Chicago. The registered enrollment target is 24 participants, below the 241-participant average among 34 other Cirrhosis, Liver trials with a reported enrollment target (90% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06871111, a Phase 1 study of Cirrhosis, Liver and Liver Diseases, is actively recruiting participants, sponsored by University of Chicago.
- RECRUITING
- Registry status
- Phase 1
- Development phase
- 24 participants
- Enrollment target
- 1
- Study location
Study Summary
The Microbiota Augmentation to Reestablish Commensal Organisms (MARCO) trial is a single center prospective adaptive phase 1b clinical trial in patients who are hospitalized with complications of liver disease and have low fecal metabolite levels (butyrate and deoxycholic acid). The study intervention is 1 of 9 novel live Commensal Consortia each containing eight commensal bacterial strains derived from healthy donors. The primary objective of the study is to determine safety and tolerability of Commensal Consortia administration.
Primary Outcome
Adverse events will be monitored for 1 year after Commensal Consortium administration using in-person contact, telephone calls and/or Patient-Reported Outcomes
Conditions Studied
Interventions
- BIOLOGICAL Commensal Bacteria Strains
Study Locations (1)
Illinois
- The University of Chicago Medical Center - Chicago
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 24 participants |
| Start Date | 2025-08-04 |
| Est. Completion | 2028-02-04 |
| Phase | Phase 1 |
What NCT06871111 shows while recruiting
NCT06871111 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 24 participants, a relatively small participant target, below the 241-participant average among 34 other Cirrhosis, Liver trials with a reported enrollment target (90% lower).
The record links to 3 conditions, with Cirrhosis, Liver appearing as the primary indexed condition, and to 1 intervention - of which Commensal Bacteria Strains is the first listed.
NCT06871111 reports a single indexed study location in Illinois.
Frequently Asked Questions
What is clinical trial NCT06871111 about?
NCT06871111 is a clinical study titled "The Microbiota Augmentation to Reestablish Commensal Organisms (MARCO) Trial". The Microbiota Augmentation to Reestablish Commensal Organisms (MARCO) trial is a single center prospective adaptive phase 1b clinical trial in patients who are hospitalized with complications of liver disease and have low fecal metabolite levels (butyrate and deoxycholic acid). The study interventi...
What is the current status of trial NCT06871111?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 24 participants. The study started on 2025-08-04. Estimated completion is 2028-02-04.
What conditions does trial NCT06871111 study?
This clinical trial studies the following conditions: Cirrhosis, Liver, Liver Diseases, Liver Failure.
What interventions are being tested in trial NCT06871111?
The interventions under investigation include: Commensal Bacteria Strains (BIOLOGICAL).
Who is sponsoring clinical trial NCT06871111?
This trial is sponsored by University of Chicago, which has 796 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06871111 being conducted?
This trial has 1 study location across Illinois. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06871111's enrollment target sits among peer trials
24 30th of 34 higher than 4 of 34 other Cirrhosis, Liver trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Cirrhosis, Liver trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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