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Chronic Pain: early-phase trial registry
139 of 302 indexed Chronic Pain trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #29 of 28,707 conditions by registered trial count.
302 US clinical trials · 139 currently recruiting · #29 of 28,707 conditions by registered trial count
Chronic Pain: 302 US clinical trials tracked, 139 recruiting.
Chronic Pain is the subject of 302 registered US clinical trials on ClinicalTrials.gov, 139 of them currently open to new participants. 15 are in Phase 3-4 (later-stage) and 41 in Phase 1-2 (earlier-stage). The most active sponsor is VA Office of Research and Development, running 16 of these trials.
Enrollment posture brief
Registry condition chronic-pain
OPEN 139 | RECR 46% | LATE 15 | EARLY 41 | RANK #29 | SPON 16
Volume-matched condition peers
Nearest open-share peer: Recurrent Glioblastoma (46% recruiting · 63 trials)
Chronic Pain lists 139 open slots (46% of 302 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Chronic Pain on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Chronic Pain is recruiting above its size-band peers.
139 of 302 indexed trials (46%) are open to enrollment, against a 37.1% average across 139 conditions with 100+ trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Chronic Pain trials is spread across many organizations.
VA Office of Research and Development accounts for 16 of 302 trials (5.3%). 155 distinct sponsors appear on at least one study for this condition label.
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Typical Chronic Pain enrolment sits around 80 participants.
Median target enrolment is 80 among the 302 trials that report a genuine target (sentinel values excluded). 164 of those (54.3%) plan for fewer than 100 participants.
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Chronic Pain research is mostly interventional.
260 interventional and 42 observational studies make up this index (86.1% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
302 total, page 6 of 7
Development of a Couple-based Mindfulness Intervention for Chronic Pain
Wayne State University
NCT02316288
Immunologic Response to Negative Cognition in Persons With Chronic Pain
Oregon Health and Science University
NCT00677911
Virtual Pain Care Management (COVID-19)
VA Office of Research and Development
NCT04539821
Development/Testing of SUMMIT: a Tool to Help Patients Manage Pain While Tapering Opioids
VA Office of Research and Development
NCT04746833
Group-based Integrative Pain Management (IPMP+ Pilot)
University of California, San Francisco
NCT05906784
Developing an Online Therapeutic Intervention for Chronic Pain in Veterans
VA Office of Research and Development
NCT03655132
An Observational Study of Integrated Chronic Pain Management in a Community Health Center
Washington University School of Medicine
NCT04490291
Immune Mechanisms of Vitamin D to Reduce Chronic Pain After Burn
University of North Carolina, Chapel Hill
NCT05619289
Managing Opioid Related Sleep Apnea With Acetazolamide
University of California, San Diego
NCT06043830
Project Relief: Developing Brain Stimulation as a Treatment for Chronic Pain
Wake Forest University Health Sciences
NCT04156802
A New Model to Reach Vulnerable Older Adults With Pain Self-management Support
University of Michigan
NCT04095650
MS Symptom Management Study
University of Washington
NCT02474940
Effects of the Nottingham Augmented Reality (AR) App for Arthritis Hand Joint Pain
VRx Medical
NCT05634291
Online Mindfulness-based Intervention to Prevent Chronic Pain
Florida State University
NCT04848428
Neuromodulation to Facilitate the Effect of Ketamine
The Neuroscience Center
NCT01816958
Study to Characterize Effects of Programming in SCS Patients Undergoing a Temporary Trial
Boston Scientific Corporation
NCT02988713
Pilot Study of Combined Treatment for Veterans With Chronic Pain & Opiate Misuse
University of New Mexi
NCT02423772
Mobile Coach for Parents of Children and Adolescents With Chronic Pain
University of California, Los Angeles
NCT03356275
Pain Rehabilitation Virtual Reality (PRVR): Innovations to Enhance Mobility in the Presence of Pain
Stanford University
NCT04636177
GET Living: Graded Exposure Treatment for Children and Adolescents With Chronic Pain
Boston Children's Hospital
NCT01974791
Negating Opioid and Pain Actively Through Intervention
Loma Linda University
NCT03306147
Latent Aging Mechanisms in Pain and Sleep
University of Florida
NCT04683640
A Mobile Intervention to Reduce Pain and Improve Health (MORPH)
Wake Forest University Health Sciences
NCT03377634
Virtual Reality, Debriefing and Chronic Pain
University of Pittsburgh
NCT05254509
At-Home Telehealth Yoga for Treating Chronic Pain in People With Alzheimer's Disease and Their Caregiver's
Palo Alto Veterans Institute for Research
NCT04512040
Evaluate the Use of the Foundation Pain Index and the Nutritional Supplement BioPlete™ in Adults With Chronic Pain
Ethos Research & Development
NCT05278533
Cognitive Behavioral Therapy for Insomnia in Chronic Pain Patients
National Institute of Nursing Research (NINR)
NCT00133601
Interoception-Based Yoga for Chronic Pain
University of Illinois at Urbana-Champaign
NCT06268197
The Effect of Chiropractic Plus Nutritional Supplement in Patients With Chronic Pain and Inflammation.
Standard Process
NCT05743855
MUSic Therapy to Improve Quality Of Life in Sickle Cell Disease (MUSIQOLS)
University Hospitals Cleveland Medical Center
NCT03556657
Nature as a Buffer Among People With Chronic Pain
Cornell University
NCT03153891
Toward Thriving: A Set of Reflective Tools to Empower Chronic Pain Patients and Help Them Envision a Personal Path to Thriving.
University of Michigan
NCT05847881
Self Transcranial Direct Current Stimulation for Pain in Older Adults With Knee Osteoarthritis
The University of Texas Health Science Center, Houston
NCT03425019
Use of a Mobile-based App for SCD Patients
Duke University
NCT01833702
Community-Engaged Options to Facilitate Opioid Reduction
Washington State University
NCT05098158
PNE Delivered With a VR Headset in Outpatient LBP Patients
Spaulding Rehabilitation Hospital
NCT04777877
Optimization and Multi-Site Feasibility of Yoga for Chronic Pain in People in YOGAMAT-II - Phase I
Butler Hospital
NCT04646148
Neuromodulation and Yoga for Mild Traumatic Brain Injury and Chronic Pain
VA Office of Research and Development
NCT04517604
Transcranial Magnetic Stimulation for Treating Women With Chronic Widespread Pain
University of Washington
NCT00524420
Tai Chi Easy for Opioid Use Disorder, Anxiety, and Chronic Pain
Asana Recovery
NCT05850533
Virtual Reality for Chronic Pain and Opioid Use Disorder Pilot
Albert Einstein College of Medicine
NCT05546749
Feasibility of Near-infrared Spectroscopy to Measure Cortical Pain Pathway (Brain) Activation During Dry Needling
Army-Baylor University Doctoral Program in Physical Therapy
NCT04170803
VR and Chronic Pain Pilot Usability Study
Albert Einstein College of Medicine
NCT04923568
KickStart30: A 30-Day Intervention for Patients With Rheumatoid Arthritis (RA)
University of Texas at Austin
NCT03993548
Non-Opioid Pramipexole and Pain
University of New Mexi
NCT03842709
Oral Ketamine for Control of Chronic Pain in Children
University of Rochester
NCT01369680
Veteran Ear Acupuncture Pilot Project
Chillicothe VA Medical Center
NCT04208659
Optimizing Open Label Placebo Rationales
Rhode Island Hospital
NCT05952960
PK Sampling After IV Oxytocin and Effects on Sensory Function in Healthy Volunteers
Wake Forest University Health Sciences
NCT03929367
Exploratory Evaluation of [11C]-NOP46
Columbia University
NCT03705819
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 19 |
| Phase 2 | 22 |
| Phase 3 | 7 |
| Phase 4 | 8 |
Top Sponsors
Named interventions
Most-linked intervention names on Chronic Pain records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Chronic Pain trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Chronic Pain page
302 registered trials, 139 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 139 Chronic Pain trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- VA Office of Research and Development sponsors the most Chronic Pain trials on record, review their full trial history before evaluating a specific study. See VA Office of Research and Development's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Chronic Pain condition card totals 302 registered trials; most-linked intervention Placebo; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.