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ClinicalTrials.gov 139 recruiting now official registry

Chronic Pain clinical trials

139 of 302 indexed Chronic Pain trials are currently recruiting.

302 US clinical trials · 139 currently recruiting

Chronic Pain is the subject of 302 registered US clinical trials on ClinicalTrials.gov, 139 of them currently open to new participants. 15 are in Phase 3-4 (later-stage) and 41 in Phase 1-2 (earlier-stage). The most active sponsor is VA Office of Research and Development, running 16 of these trials.

The research picture

Chronic Pain has 302 registered US clinical trials, 139 of them open to new participants right now, about 46% of the total.

139
recruiting participants now
46%
of trials open to enrollment
15
in Phase 3–4 (later-stage)
16
top sponsor: VA Office of Research and Development
Phase 119Phase 222Phase 37Phase 48

Active & Recent Trials

302 total, page 6 of 7

COMPLETED NA 48 participants

Development of a Couple-based Mindfulness Intervention for Chronic Pain

Wayne State University

NCT02316288

COMPLETED Early Phase 1 47 participants

Immunologic Response to Negative Cognition in Persons With Chronic Pain

Oregon Health and Science University

NCT00677911

COMPLETED NA 44 participants

Virtual Pain Care Management (COVID-19)

VA Office of Research and Development

NCT04539821

COMPLETED NA 44 participants

Development/Testing of SUMMIT: a Tool to Help Patients Manage Pain While Tapering Opioids

VA Office of Research and Development

NCT04746833

COMPLETED NA 44 participants

Group-based Integrative Pain Management (IPMP+ Pilot)

University of California, San Francisco

NCT05906784

COMPLETED NA 42 participants

Developing an Online Therapeutic Intervention for Chronic Pain in Veterans

VA Office of Research and Development

NCT03655132

COMPLETED 42 participants

An Observational Study of Integrated Chronic Pain Management in a Community Health Center

Washington University School of Medicine

NCT04490291

COMPLETED Phase 2 40 participants

Immune Mechanisms of Vitamin D to Reduce Chronic Pain After Burn

University of North Carolina, Chapel Hill

NCT05619289

COMPLETED Phase 2 39 participants

Managing Opioid Related Sleep Apnea With Acetazolamide

University of California, San Diego

NCT06043830

COMPLETED NA 38 participants

Project Relief: Developing Brain Stimulation as a Treatment for Chronic Pain

Wake Forest University Health Sciences

NCT04156802

COMPLETED NA 38 participants

A New Model to Reach Vulnerable Older Adults With Pain Self-management Support

University of Michigan

NCT04095650

COMPLETED NA 37 participants

MS Symptom Management Study

University of Washington

NCT02474940

COMPLETED NA 36 participants

Effects of the Nottingham Augmented Reality (AR) App for Arthritis Hand Joint Pain

VRx Medical

NCT05634291

COMPLETED NA 36 participants

Online Mindfulness-based Intervention to Prevent Chronic Pain

Florida State University

NCT04848428

COMPLETED 35 participants

Neuromodulation to Facilitate the Effect of Ketamine

The Neuroscience Center

NCT01816958

COMPLETED NA 35 participants

Study to Characterize Effects of Programming in SCS Patients Undergoing a Temporary Trial

Boston Scientific Corporation

NCT02988713

COMPLETED NA 35 participants

Pilot Study of Combined Treatment for Veterans With Chronic Pain & Opiate Misuse

University of New Mexi

NCT02423772

COMPLETED NA 34 participants

Mobile Coach for Parents of Children and Adolescents With Chronic Pain

University of California, Los Angeles

NCT03356275

COMPLETED NA 34 participants

Pain Rehabilitation Virtual Reality (PRVR): Innovations to Enhance Mobility in the Presence of Pain

Stanford University

NCT04636177

COMPLETED NA 34 participants

GET Living: Graded Exposure Treatment for Children and Adolescents With Chronic Pain

Boston Children's Hospital

NCT01974791

COMPLETED NA 33 participants

Negating Opioid and Pain Actively Through Intervention

Loma Linda University

NCT03306147

COMPLETED Phase 2 33 participants

Latent Aging Mechanisms in Pain and Sleep

University of Florida

NCT04683640

COMPLETED NA 33 participants

A Mobile Intervention to Reduce Pain and Improve Health (MORPH)

Wake Forest University Health Sciences

NCT03377634

COMPLETED NA 32 participants

Virtual Reality, Debriefing and Chronic Pain

University of Pittsburgh

NCT05254509

COMPLETED NA 30 participants

At-Home Telehealth Yoga for Treating Chronic Pain in People With Alzheimer's Disease and Their Caregiver's

Palo Alto Veterans Institute for Research

NCT04512040

COMPLETED NA 30 participants

Evaluate the Use of the Foundation Pain Index and the Nutritional Supplement BioPlete™ in Adults With Chronic Pain

Ethos Research & Development

NCT05278533

COMPLETED Phase 1 28 participants

Cognitive Behavioral Therapy for Insomnia in Chronic Pain Patients

National Institute of Nursing Research (NINR)

NCT00133601

COMPLETED NA 26 participants

Interoception-Based Yoga for Chronic Pain

University of Illinois at Urbana-Champaign

NCT06268197

COMPLETED NA 25 participants

The Effect of Chiropractic Plus Nutritional Supplement in Patients With Chronic Pain and Inflammation.

Standard Process

NCT05743855

COMPLETED NA 24 participants

MUSic Therapy to Improve Quality Of Life in Sickle Cell Disease (MUSIQOLS)

University Hospitals Cleveland Medical Center

NCT03556657

COMPLETED NA 23 participants

Nature as a Buffer Among People With Chronic Pain

Cornell University

NCT03153891

COMPLETED NA 23 participants

Toward Thriving: A Set of Reflective Tools to Empower Chronic Pain Patients and Help Them Envision a Personal Path to Thriving.

University of Michigan

NCT05847881

COMPLETED NA 21 participants

Self Transcranial Direct Current Stimulation for Pain in Older Adults With Knee Osteoarthritis

The University of Texas Health Science Center, Houston

NCT03425019

COMPLETED 21 participants

Use of a Mobile-based App for SCD Patients

Duke University

NCT01833702

COMPLETED NA 21 participants

Community-Engaged Options to Facilitate Opioid Reduction

Washington State University

NCT05098158

COMPLETED 20 participants

PNE Delivered With a VR Headset in Outpatient LBP Patients

Spaulding Rehabilitation Hospital

NCT04777877

COMPLETED NA 20 participants

Optimization and Multi-Site Feasibility of Yoga for Chronic Pain in People in YOGAMAT-II - Phase I

Butler Hospital

NCT04646148

COMPLETED NA 19 participants

Neuromodulation and Yoga for Mild Traumatic Brain Injury and Chronic Pain

VA Office of Research and Development

NCT04517604

COMPLETED Phase 2 19 participants

Transcranial Magnetic Stimulation for Treating Women With Chronic Widespread Pain

University of Washington

NCT00524420

COMPLETED NA 19 participants

Tai Chi Easy for Opioid Use Disorder, Anxiety, and Chronic Pain

Asana Recovery

NCT05850533

COMPLETED NA 18 participants

Virtual Reality for Chronic Pain and Opioid Use Disorder Pilot

Albert Einstein College of Medicine

NCT05546749

COMPLETED Early Phase 1 18 participants

Feasibility of Near-infrared Spectroscopy to Measure Cortical Pain Pathway (Brain) Activation During Dry Needling

Army-Baylor University Doctoral Program in Physical Therapy

NCT04170803

COMPLETED NA 16 participants

VR and Chronic Pain Pilot Usability Study

Albert Einstein College of Medicine

NCT04923568

COMPLETED NA 13 participants

KickStart30: A 30-Day Intervention for Patients With Rheumatoid Arthritis (RA)

University of Texas at Austin

NCT03993548

COMPLETED Early Phase 1 13 participants

Non-Opioid Pramipexole and Pain

University of New Mexi

NCT03842709

COMPLETED Phase 1 12 participants

Oral Ketamine for Control of Chronic Pain in Children

University of Rochester

NCT01369680

COMPLETED NA 12 participants

Veteran Ear Acupuncture Pilot Project

Chillicothe VA Medical Center

NCT04208659

COMPLETED NA 11 participants

Optimizing Open Label Placebo Rationales

Rhode Island Hospital

NCT05952960

COMPLETED Phase 4 11 participants

PK Sampling After IV Oxytocin and Effects on Sensory Function in Healthy Volunteers

Wake Forest University Health Sciences

NCT03929367

COMPLETED Early Phase 1 10 participants

Exploratory Evaluation of [11C]-NOP46

Columbia University

NCT03705819

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Phase Distribution

PhaseTrial count
Phase 1 19
Phase 2 22
Phase 3 7
Phase 4 8

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Chronic Pain Trial Landscape

302 indexed Chronic Pain studies · 139 recruiting (46%).

Phase mix: 15 late (III/IV) vs 41 early (I/II).

Top sponsor: VA Office of Research and Development (16 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Chronic Pain?

PlainTrial tracks 302 US clinical trials for Chronic Pain, of which 139 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Chronic Pain?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.