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ClinicalTrials.gov 13 recruiting now official registry

Chronic Lymphocytic Leukemia (CLL) clinical trials

Every US clinical trial registered for Chronic Lymphocytic Leukemia (CLL) — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.

30 US clinical trials · 13 currently recruiting

The research picture

Chronic Lymphocytic Leukemia (CLL) has 30 registered US clinical trials, 13 of them open to new participants right now — about 43% of the total.

13
recruiting participants now
43%
of trials open to enrollment
0
in Phase 3–4 (later-stage)
4
top sponsor: Memorial Sloan Kettering Cancer Center

Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.

Active & Recent Trials

RECRUITING 1,263 participants

Collection of Human Samples to Study Hairy Cell and Other Leukemias, and to Develop Recombinant Immunotoxins for Cancer Treatment

National Cancer Institute (NCI)

NCT01087333

RECRUITING Phase 1 572 participants

A Study of NX-5948 in Adults With Relapsed/Refractory B-cell Malignancies

Nurix Therapeutics

NCT05131022

RECRUITING 300 participants

A Study of Patients With Relapsed/Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma Treated With Lisocabtagene Maraleucel in the Post-Marketing Setting

Juno Therapeutics, Inc., a Bristol-Myers Squibb Company

NCT06788639

RECRUITING Phase 1 248 participants

A Study of NX-2127 in Adults With Relapsed/Refractory B-cell Malignancies

Nurix Therapeutics

NCT04830137

RECRUITING Phase 2 230 participants

Study of Zanubrutinib, Obinutuzumab, and Venetoclax in Patients With Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Leukemia (SLL)

Memorial Sloan Kettering Cancer Center

NCT03824483

RECRUITING 135 participants

Observational Study of Cardiac Arrhythmias During Treatment With BTK Inhibitors or Venetoclax

National Heart, Lung, and Blood Institute (NHLBI)

NCT05724121

RECRUITING Phase 1 106 participants

A Phase 1 Study of UB-VV111 With and Without Rapamycin in Relapsed/Refractory CD19+ B-cell Malignancies

Umoja Biopharma

NCT06528301

RECRUITING Phase 1 100 participants

CAR-20/19-T Cells in Patients With Relapsed Refractory B Cell Malignancies

Medical College of Wisconsin

NCT04186520

RECRUITING Phase 2 100 participants

A Study of NX-5948 in Adults With CLL/SLL Previously Treated With a Bruton's Tyrosine Kinase Inhibitor and a B-cell Lymphoma-2 Inhibitor (DAYBreak CLL-201)

Nurix Therapeutics

NCT07221500

RECRUITING 100 participants

Predictors of Health-Related QOL in Adults With CLL or Small Lymphocytic Lymphoma

H. Lee Moffitt Cancer Center and Research Institute

NCT07030400

RECRUITING Phase 2 75 participants

Study to Assess Change in Disease Activity and Adverse Events of Oral Venetoclax With Intravenous (IV) Obinutuzumab in Adult Participants With Recurring Chronic Lymphocytic Leukemia (CLL)

AbbVie

NCT04895436

RECRUITING Phase 2 45 participants

Zanubrutinib and Venetoclax in CLL (ZANU-VEN)

Dana-Farber Cancer Institute

NCT05168930

RECRUITING Early Phase 1 30 participants

Immune Profiling of CLL/SLL Treated With First-Line Pirtobrutinib

National Heart, Lung, and Blood Institute (NHLBI)

NCT07428707

ACTIVE NOT RECRUITING Phase 2 100 participants

The Combination of Venetoclax and Obinutuzumab in People With Chronic Lymphocytic Leukemia (CLL)

Memorial Sloan Kettering Cancer Center

NCT04447768

ACTIVE NOT RECRUITING Phase 2 81 participants

Assessing Minimal Residual Disease by Next- Generation Sequencing to Minimize Exposure in People With CLL or SLL Who Have Been Treated With Venetoclax

Memorial Sloan Kettering Cancer Center

NCT04419519

ACTIVE NOT RECRUITING Phase 2 72 participants

Acalabrutinib, Venetoclax, and Obinutuzumab for Initial Therapy of CLL

Dana-Farber Cancer Institute

NCT03580928

ACTIVE NOT RECRUITING Phase 1 68 participants

Multi-virus CTLs Expressing CD19 Chimeric Receptors, CD19 Positive Malignancies Post SCT, MULTIPRAT

Baylor College of Medicine

NCT00840853

ACTIVE NOT RECRUITING Phase 1 39 participants

A Trial of "Armored" CAR T Cells Targeting CD19 For Patients With Relapsed CD19+ Hematologic Malignancies

Memorial Sloan Kettering Cancer Center

NCT03085173

ACTIVE NOT RECRUITING Phase 1 30 participants

A Clinical Trial of BP1002 in Patients With Advanced Lymphoid Malignancies

Bio-Path Holdings

NCT04072458

COMPLETED 1,504 participants

informCLL™: A Disease Registry for Patients With Chronic Lymphocytic Leukemia

Pharmacyclics

NCT02582879

COMPLETED Phase 2 99 participants

Ofatumumab Plus Bendamustine in Frontline and Relapsed Chronic Lymphocytic Leukaemia (CLL)

Novartis Pharmaceuticals

NCT01520922

COMPLETED Phase 2 80 participants

HLA-Mismatched Unrelated Donor Bone Marrow Transplantation With Post-Transplantation Cyclophosphamide

Center for International Blood and Marrow Transplant Research

NCT02793544

COMPLETED Phase 1 39 participants

Study of the Efficacy and Safety of Ublituximab in Patients With Relapsed or Refractory B-cell Non-Hodgkin Lymphoma

TG Therapeutics

NCT01647971

COMPLETED Phase 2 39 participants

Acalabrutinib and High Frequency Low Dose Subcutaneous Rituximab in Patients With Previously Untreated Chronic Lymphocytic Leukemia / Small Lymphocytic Lymphoma

University of Rochester

NCT03788291

COMPLETED Early Phase 1 33 participants

Serologic Response to SHINGRIX Vaccine in Patients With CLL and WM Treated With BTK Inhibitors

University of Rochester

NCT03771157

COMPLETED Phase 1 24 participants

Study of AMD3100 (Plerixafor) and Rituximab in Patients With Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma

Genzyme, a Sanofi Company

NCT00694590

COMPLETED Phase 1 18 participants

CLBR001 and SWI019 in Patients With Relapsed / Refractory B-cell Malignancies

Calibr, a division of Scripps Research

NCT04450069

COMPLETED Phase 1 10 participants

Single Treatment With FT1050 of an Ex-vivo Modulated Umbilical Cord Blood Unit

Fate Therapeutics

NCT01527838

COMPLETED NA 10 participants

Bone Marrow and Kidney Transplant for Patients With Chronic Kidney Disease and Blood Disorders

Massachusetts General Hospital

NCT01758042

COMPLETED Phase 1 6 participants

Treatment of B-Chronic Lymphocytic Leukemia (B-CLL) With Autologous CD40 Ligand and IL-2-Expressing Tumor Cells

Baylor College of Medicine

NCT00458679

Phase Distribution

PhaseTrial count
Phase 1 14
Phase 2 10

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Chronic Lymphocytic Leukemia (CLL) Trial Landscape

ClinicalTrials.gov lists 30 US studies indexed under Chronic Lymphocytic Leukemia (CLL), and 13 of those are currently open to recruitment — roughly 43% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Chronic Lymphocytic Leukemia (CLL) shows 0 late-stage studies (Phase 3 and Phase 4 combined) alongside 24 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Chronic Lymphocytic Leukemia (CLL) is led by Memorial Sloan Kettering Cancer Center with 4 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 30 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Chronic Lymphocytic Leukemia (CLL)?

PlainTrial tracks 30 US clinical trials for Chronic Lymphocytic Leukemia (CLL), of which 13 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Chronic Lymphocytic Leukemia (CLL)?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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