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NCT06528301 · ClinicalTrials.gov registry record · Phase 1
A Phase 1 Study of UB-VV111 With and Without Rapamycin in Relapsed/Refractory CD19+ B-cell Malignancies
A Phase 1 study of Lymphoma, B-Cell and Chronic Lymphocytic Leukemia (CLL), sponsored by Umoja Biopharma.
- Recruiting
- Registry status
- Phase 1
- Development phase
- 106
- Enrollment target
- 8
- Study locations
NCT06528301: Recruiting Phase 1 study of Lymphoma, B-Cell and Chronic Lymphocytic Leukemia (CLL), sponsored by Umoja Biopharma.
NCT06528301 is a Phase 1 study of Lymphoma, B-Cell and Chronic Lymphocytic Leukemia (CLL) that is actively recruiting participants, run by Umoja Biopharma. The registered enrollment target is 106 participants, below the 198-participant average among 31 other Lymphoma, B-Cell trials with a reported enrollment target (46% lower). The trial reports 8 study locations across 8 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06528301, a Phase 1 study of Lymphoma, B-Cell and Chronic Lymphocytic Leukemia (CLL), is actively recruiting participants, sponsored by Umoja Biopharma.
- RECRUITING
- Registry status
- Phase 1
- Development phase
- 106 participants
- Enrollment target
- 8
- Study locations
Study Summary
This study is a Phase 1 dose-escalation and dose-confirmation study to evaluate the safety and antitumor activity of UB-VV111. The study will enroll patients with relapsed/refractory large B-cell lymphoma (LBCL) and chronic lymphocytic leukemia (CLL).
Primary Outcome
Percentage of participants with commonly reported AEs overall and by severity
Conditions Studied
Interventions
- DRUG rapamycin
- GENETIC UB-VV111
Study Locations (8)
California
- City of Hope - Duarte
Illinois
- The David and Etta Jonas Center for Cellular Therapy - Chicago
Missouri
- Washington University School of Medicine/Siteman Cancer Center - St Louis
Nebraska
- University of Nebraska Medical Center - Omaha
Ohio
- University of Cincinnatti Medical Center - Cincinnati
Washington
- Fred Hutch Cancer Center - Seattle
New South Wales
- Royal North Shore Hospital - Saint Leonards
Victoria
- St. Vincent's Hospital Melbourne - Fitzroy
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 106 participants |
| Start Date | 2025-03-10 |
| Est. Completion | 2029-03 |
| Phase | Phase 1 |
What NCT06528301 shows while recruiting
NCT06528301 is an interventional study that assigns participants to a tested intervention. The registered 106 participants enrollment target is mid-sized for trials with a published cap, below the 198-participant average among 31 other Lymphoma, B-Cell trials with a reported enrollment target (46% lower).
The record links to 4 conditions, with Lymphoma, B-Cell appearing as the primary indexed condition, and to 2 interventions - of which rapamycin is the first listed.
NCT06528301 lists 8 locations in 8 states (California, Illinois, Missouri).
Frequently Asked Questions
What is clinical trial NCT06528301 about?
NCT06528301 is a clinical study titled "A Phase 1 Study of UB-VV111 With and Without Rapamycin in Relapsed/Refractory CD19+ B-cell Malignancies". This study is a Phase 1 dose-escalation and dose-confirmation study to evaluate the safety and antitumor activity of UB-VV111. The study will enroll patients with relapsed/refractory large B-cell lymphoma (LBCL) and chronic lymphocytic leukemia (CLL).
What is the current status of trial NCT06528301?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 106 participants. The study started on 2025-03-10. Estimated completion is 2029-03.
What conditions does trial NCT06528301 study?
This clinical trial studies the following conditions: Lymphoma, B-Cell, Chronic Lymphocytic Leukemia (CLL), Lymphoma, Non-Hodgkin (NHL), Lymphoma, Large B-Cell, Diffuse (DLBCL).
What interventions are being tested in trial NCT06528301?
The interventions under investigation include: rapamycin (DRUG), UB-VV111 (GENETIC).
Who is sponsoring clinical trial NCT06528301?
This trial is sponsored by Umoja Biopharma, which has 1 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06528301 being conducted?
This trial has 8 study locations across California, Illinois, Missouri, Nebraska, Ohio. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Lymphoma, B-Cell
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06528301's enrollment target sits among peer trials
106 11th of 31 higher than 21 of 31 other Lymphoma, B-Cell trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Lymphoma, B-Cell trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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