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NCT01805440 · ClinicalTrials.gov registry record · NA
Uridine Adolescent Bipolar Depression Randomized Controlled Trial
A NA study of Bipolar Disorder and Bipolar Depression, sponsored by University of Utah.
- Completed
- Registry status
- NA
- Development phase
- 62
- Enrollment target
- 1
- Study location
NCT01805440: Completed NA study of Bipolar Disorder and Bipolar Depression, sponsored by University of Utah.
NCT01805440 is a NA study of Bipolar Disorder and Bipolar Depression that has completed, run by University of Utah. The registered enrollment target is 62 participants, below the 332-participant average among 162 other Bipolar Disorder trials with a reported enrollment target (81% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01805440, a NA study of Bipolar Disorder and Bipolar Depression, has completed, sponsored by University of Utah.
- COMPLETED
- Registry status
- NA
- Development phase
- 62 participants
- Enrollment target
- 1
- Study location
Study Summary
This is a randomized, double-blind, placebo-controlled study of the investigational drug uridine as a treatment for depressed adolescents with bipolar disorder (i.e. "bipolar depression"). Participants initially randomized to placebo who complete the 6-week protocol will be offered 6 months of open-label uridine treatment and follow-up. Participants initially randomized to uridine will be offered the open-label treatment as well.
Primary Outcome
Magnetic Resonance Spectroscopy is a safe, non-invasive method for measuring brain chemicals thought to be involved in mood disorders, such as GLX (glutamate + glutamine). Previous research indicates that adolescents with bipolar depression have elevated Glx concentrations, compared with controls. The measurement of Glx with 1H-MRS has the potential to identify translational biomarkers of juvenile BD pathophysiology and treatment response.
Conditions Studied
Interventions
- DRUG Placebo
- DRUG Uridine
Study Locations (1)
Utah
- University of Utah - Salt Lake City
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 62 participants |
| Start Date | 2013-08 |
| Est. Completion | 2015-12 |
| Phase | NA |
What the finished NCT01805440 record still lists
NCT01805440 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 62 participants, a relatively small participant target, below the 332-participant average among 162 other Bipolar Disorder trials with a reported enrollment target (81% lower).
The record links to 3 conditions, with Bipolar Disorder appearing as the primary indexed condition, and to 2 interventions - of which Placebo is the first listed.
NCT01805440 reports a single indexed study location in Utah.
Frequently Asked Questions
What is clinical trial NCT01805440 about?
NCT01805440 is a clinical study titled "Uridine Adolescent Bipolar Depression Randomized Controlled Trial". This is a randomized, double-blind, placebo-controlled study of the investigational drug uridine as a treatment for depressed adolescents with bipolar disorder (i.e. "bipolar depression"). Participants initially randomized to placebo who complete the 6-week protocol will be offered 6 months of open-...
What is the current status of trial NCT01805440?
This trial is currently completed. It is a NA study. The enrollment target is 62 participants. The study started on 2013-08. Estimated completion is 2015-12.
What conditions does trial NCT01805440 study?
This clinical trial studies the following conditions: Bipolar Disorder, Bipolar Depression, Manic Depression.
What interventions are being tested in trial NCT01805440?
The interventions under investigation include: Placebo (DRUG), Uridine (DRUG).
Who is sponsoring clinical trial NCT01805440?
This trial is sponsored by University of Utah, which has 818 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT01805440 being conducted?
This trial has 1 study location across Utah. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Bipolar Disorder
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT01805440's enrollment target sits among peer trials
62 87th of 162 higher than 76 of 162 other Bipolar Disorder trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Bipolar Disorder trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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