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ClinicalTrials.gov 37 recruiting now official registry

Bipolar Disorder clinical trials

37 of 163 indexed Bipolar Disorder trials are currently recruiting.

163 US clinical trials · 37 currently recruiting

Bipolar Disorder is the subject of 163 registered US clinical trials on ClinicalTrials.gov, 37 of them currently open to new participants. 45 are in Phase 3-4 (later-stage) and 15 in Phase 1-2 (earlier-stage). The most active sponsor is Massachusetts General Hospital, running 11 of these trials.

The research picture

Bipolar Disorder has 163 registered US clinical trials, 37 of them open to new participants right now, about 23% of the total.

37
recruiting participants now
23%
of trials open to enrollment
45
in Phase 3–4 (later-stage)
11
top sponsor: Massachusetts General Hospital
Phase 13Phase 212Phase 323Phase 422

Active & Recent Trials

163 total, page 3 of 4

COMPLETED NA 60 participants

Disseminating Evidence-based Mood Disorder Chronic Care Models

University of Michigan

NCT01615458

COMPLETED NA 60 participants

A Pilot Study of Citicoline add-on Therapy in Patients With Bipolar Disorder or Major Depressive Disorder and Amphetamine Abuse or Dependence

University of Texas Southwestern Medical Center

NCT00377299

COMPLETED NA 60 participants

Acute Alcohol Response In Bipolar Disorder: a fMRI Study

University of Texas at Austin

NCT04063384

COMPLETED Phase 4 60 participants

A Study of Risperidone Monotherapy in Bipolar Anxiety

University of South Florida

NCT00167479

COMPLETED NA 60 participants

Improving Care for Patients With Bipolar Disorder

University of Michigan

NCT00222755

COMPLETED NA 59 participants

Cornerstone Program for Transition-Age Youth Study Protocol for a Randomized Controlled Trial

New York University

NCT02696109

COMPLETED Phase 1 58 participants

Evaluating the Effectiveness of Family-Focused Psychoeducation in Treating Adolescents With Bipolar Disorder

University of California, Los Angeles

NCT00571402

COMPLETED 57 participants

Insulin Resistance in Patients With Major Depression

Stanford University

NCT01106313

COMPLETED NA 56 participants

In-person vs. Remote Wellness Support

The University of Texas Health Science Center at San Antonio

NCT04526067

COMPLETED NA 56 participants

Neuromodulation for Enhancement of Emotion Regulation in Bipolar Mood Disorders

Massachusetts General Hospital

NCT04284267

COMPLETED NA 55 participants

Life Goals Behavioral Change to Improve Outcomes for Veterans With Serious Mental Illness

VA Office of Research and Development

NCT01244854

COMPLETED Phase 2 54 participants

Imaging GABAergic/Glutamatergic Drugs in Bipolar Alcoholics Alcoholics

Medical University of South Carolina

NCT03220776

COMPLETED Phase 3 54 participants

Double-blind, Placebo-Controlled Divalproex Sodium ER in Bipolar I or Bipolar II Depression

University Hospitals Cleveland Medical Center

NCT00194116

COMPLETED NA 54 participants

Effectiveness of Cognitive Behavioral Therapy for Treating Depression in People With Bipolar I Disorder

Massachusetts General Hospital

NCT00595387

COMPLETED NA 52 participants

Early Family-Focused Treatment for Youth at Risk for Bipolar Disorder

University of California, Los Angeles

NCT00943085

COMPLETED Phase 3 52 participants

Sleep Disturbance and Bipolar Disorder

University of California, Berkeley

NCT00993850

COMPLETED 50 participants

Effectiveness of Two Self Assessment Tools: KIOS-Bipolar or eMoods

The University of Texas Health Science Center at San Antonio

NCT02418910

COMPLETED NA 50 participants

Modeling Mood Course to Detect Markers of Effective Adaptive Interventions

University of Wisconsin, Madison

NCT03358238

COMPLETED NA 50 participants

Omega-3 Dietary Supplements in Schizophrenia

Delbert Robinson

NCT01786239

COMPLETED 50 participants

Pediatric Bipolar Disorder Study at UCLA

University of California, Los Angeles

NCT00961935

COMPLETED Phase 4 49 participants

Ziprasidone in Bipolar Disorder With Comorbid Lifetime Panic or Generalized Anxiety Disorder(GAD)

VA Palo Alto Health Care System

NCT01172652

COMPLETED NA 49 participants

Effectiveness of a Mobile Texting Intervention for People With Serious Mental Illness

University of Washington

NCT03062267

COMPLETED Phase 4 46 participants

FMRI Study of Brain Response Before and After Lithium Treatment in People With Bipolar Disorder

Indiana University

NCT00596622

COMPLETED Phase 3 46 participants

Placebo Controlled Trial of Valproate and Risperidone in Young Children With Bipolar Disorders

Children's Hospital Medical Center, Cincinnati

NCT00221403

COMPLETED 45 participants

Rostral Dorsal Cingulum Bundle Connectivity in Patients With Bipolar Disorder

University Hospitals Cleveland Medical Center

NCT02655978

COMPLETED 44 participants

Antipsychotics and Blood Vessel Function

Jess G. Fiedorowicz

NCT00585273

COMPLETED NA 43 participants

Customized Medication Adherence Enhancement for Adults With Bipolar Disorder

University Hospitals Cleveland Medical Center

NCT00830310

COMPLETED Phase 2 42 participants

Clozapine for Treatment-Resistant Mania

National Institute of Mental Health (NIMH)

NCT00029458

COMPLETED Phase 4 41 participants

Iloperidone in Mixed States of Bipolar Disorder

The University of Texas Health Science Center at San Antonio

NCT02413918

COMPLETED 40 participants

Understanding Treatment Adherence Among Individuals With Rapid Cycling Bipolar Disorder

Case Western Reserve University

NCT00183703

COMPLETED Phase 4 40 participants

Prediction of Clinical Response to SSRI Treatment in Bipolar Disorder Using Serotonin 1A Receptor PET Imaging

New York State Psychiatric Institute

NCT02473250

COMPLETED Phase 3 40 participants

Study of Quetiapine Monotherapy in Ambulatory Bipolar Spectrum Disorder With Moderate-to-Severe Hypomanic Symptoms or Mild Manic Symptoms

Lindner Center of HOPE

NCT00277667

COMPLETED NA 40 participants

Peer-delivered and Technology-Assisted Integrated Illness Management and Recovery

Dartmouth-Hitchcock Medical Center

NCT04481737

COMPLETED NA 38 participants

Medication Adherence in Hypertensive Individuals With Bipolar Disorder

Case Western Reserve University

NCT02983877

COMPLETED NA 36 participants

Interpersonal and Social Rhythm Therapy for Adolescents With Bipolar Disorder

University of Washington

NCT00576355

COMPLETED NA 36 participants

Improving Adherence in Adolescents and Young Adults With Bipolar Disorder

Case Western Reserve University

NCT04348604

COMPLETED NA 35 participants

Mindfulness Based Cognitive Therapy for Youth With Anxiety at Risk for Bipolar Disorder

University of Cincinnati

NCT02090595

COMPLETED Phase 4 33 participants

Equetro for the Treatment of Mania in Children Ages 6-12 With Bipolar Disorder

Massachusetts General Hospital

NCT00181870

COMPLETED NA 33 participants

Vitamin D Supplementation for Bipolar Depression

University of Massachusetts, Worcester

NCT01884844

COMPLETED 32 participants

Self Focus in Bipolar Disorder: A Functional Magnetic Resonance Imaging (fMRI) Study

Massachusetts General Hospital

NCT02253225

COMPLETED Phase 4 32 participants

12- Week Open Label Treatment of Refractory Bipolar Depression

The University of Texas Health Science Center at San Antonio

NCT00223496

COMPLETED NA 30 participants

Bioequivalency Study of 300 mg Lithium Carbonate Under Fed Conditions

Roxane Laboratories

NCT00602394

COMPLETED Phase 4 30 participants

A Double-Blind, Placebo-Controlled Study of Galantamine to Improve Cognitive Dysfunction in Bipolar Disorder

Cambridge Health Alliance

NCT00195845

COMPLETED NA 30 participants

Proactive Psychiatry Consultation for Patients With Cancer and Severe Mental Illness

Massachusetts General Hospital

NCT02594696

COMPLETED Phase 2 30 participants

Acupuncture as a Supplemental Treatment for Bipolar Depression

University of Texas Southwestern Medical Center

NCT00071669

COMPLETED NA 30 participants

Functional Remediation for Bipolar Disorder

University of Michigan

NCT03403179

COMPLETED 30 participants

Lamotrigine in the Treatment of Bipolar Disorder in Women of Reproductive Age

Stanford University

NCT00238576

COMPLETED NA 30 participants

Bioequivalency Study of 450 mg Lithium Carbonate Under Fasting Conditions

Roxane Laboratories

NCT00602381

COMPLETED NA 29 participants

Bioequivalency Study of 300 mg Lithium Carbonate Under Fasting Conditions

Roxane Laboratories

NCT00601536

COMPLETED Phase 4 28 participants

Lamictal As Add on Treatment in Mixed States of Bipolar Disorder

The University of Texas Health Science Center at San Antonio

NCT00223509

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Phase Distribution

PhaseTrial count
Phase 1 3
Phase 2 12
Phase 3 23
Phase 4 22

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Bipolar Disorder Trial Landscape

163 indexed Bipolar Disorder studies · 37 recruiting (23%).

Phase mix: 45 late (III/IV) vs 15 early (I/II).

Top sponsor: Massachusetts General Hospital (11 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Bipolar Disorder?

PlainTrial tracks 163 US clinical trials for Bipolar Disorder, of which 37 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Bipolar Disorder?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.