Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Bipolar Disorder clinical trials
37 of 163 indexed Bipolar Disorder trials are currently recruiting.
163 US clinical trials · 37 currently recruiting
Bipolar Disorder is the subject of 163 registered US clinical trials on ClinicalTrials.gov, 37 of them currently open to new participants. 45 are in Phase 3-4 (later-stage) and 15 in Phase 1-2 (earlier-stage). The most active sponsor is Massachusetts General Hospital, running 11 of these trials.
The research picture
Bipolar Disorder has 163 registered US clinical trials, 37 of them open to new participants right now, about 23% of the total.
- 37
- recruiting participants now
- 23%
- of trials open to enrollment
- 45
- in Phase 3–4 (later-stage)
- 11
- top sponsor: Massachusetts General Hospital
Active & Recent Trials
163 total, page 3 of 4
Disseminating Evidence-based Mood Disorder Chronic Care Models
University of Michigan
NCT01615458
A Pilot Study of Citicoline add-on Therapy in Patients With Bipolar Disorder or Major Depressive Disorder and Amphetamine Abuse or Dependence
University of Texas Southwestern Medical Center
NCT00377299
Acute Alcohol Response In Bipolar Disorder: a fMRI Study
University of Texas at Austin
NCT04063384
A Study of Risperidone Monotherapy in Bipolar Anxiety
University of South Florida
NCT00167479
Improving Care for Patients With Bipolar Disorder
University of Michigan
NCT00222755
Cornerstone Program for Transition-Age Youth Study Protocol for a Randomized Controlled Trial
New York University
NCT02696109
Evaluating the Effectiveness of Family-Focused Psychoeducation in Treating Adolescents With Bipolar Disorder
University of California, Los Angeles
NCT00571402
Insulin Resistance in Patients With Major Depression
Stanford University
NCT01106313
In-person vs. Remote Wellness Support
The University of Texas Health Science Center at San Antonio
NCT04526067
Neuromodulation for Enhancement of Emotion Regulation in Bipolar Mood Disorders
Massachusetts General Hospital
NCT04284267
Life Goals Behavioral Change to Improve Outcomes for Veterans With Serious Mental Illness
VA Office of Research and Development
NCT01244854
Imaging GABAergic/Glutamatergic Drugs in Bipolar Alcoholics Alcoholics
Medical University of South Carolina
NCT03220776
Double-blind, Placebo-Controlled Divalproex Sodium ER in Bipolar I or Bipolar II Depression
University Hospitals Cleveland Medical Center
NCT00194116
Effectiveness of Cognitive Behavioral Therapy for Treating Depression in People With Bipolar I Disorder
Massachusetts General Hospital
NCT00595387
Early Family-Focused Treatment for Youth at Risk for Bipolar Disorder
University of California, Los Angeles
NCT00943085
Sleep Disturbance and Bipolar Disorder
University of California, Berkeley
NCT00993850
Effectiveness of Two Self Assessment Tools: KIOS-Bipolar or eMoods
The University of Texas Health Science Center at San Antonio
NCT02418910
Modeling Mood Course to Detect Markers of Effective Adaptive Interventions
University of Wisconsin, Madison
NCT03358238
Omega-3 Dietary Supplements in Schizophrenia
Delbert Robinson
NCT01786239
Pediatric Bipolar Disorder Study at UCLA
University of California, Los Angeles
NCT00961935
Ziprasidone in Bipolar Disorder With Comorbid Lifetime Panic or Generalized Anxiety Disorder(GAD)
VA Palo Alto Health Care System
NCT01172652
Effectiveness of a Mobile Texting Intervention for People With Serious Mental Illness
University of Washington
NCT03062267
FMRI Study of Brain Response Before and After Lithium Treatment in People With Bipolar Disorder
Indiana University
NCT00596622
Placebo Controlled Trial of Valproate and Risperidone in Young Children With Bipolar Disorders
Children's Hospital Medical Center, Cincinnati
NCT00221403
Rostral Dorsal Cingulum Bundle Connectivity in Patients With Bipolar Disorder
University Hospitals Cleveland Medical Center
NCT02655978
Antipsychotics and Blood Vessel Function
Jess G. Fiedorowicz
NCT00585273
Customized Medication Adherence Enhancement for Adults With Bipolar Disorder
University Hospitals Cleveland Medical Center
NCT00830310
Clozapine for Treatment-Resistant Mania
National Institute of Mental Health (NIMH)
NCT00029458
Iloperidone in Mixed States of Bipolar Disorder
The University of Texas Health Science Center at San Antonio
NCT02413918
Understanding Treatment Adherence Among Individuals With Rapid Cycling Bipolar Disorder
Case Western Reserve University
NCT00183703
Prediction of Clinical Response to SSRI Treatment in Bipolar Disorder Using Serotonin 1A Receptor PET Imaging
New York State Psychiatric Institute
NCT02473250
Study of Quetiapine Monotherapy in Ambulatory Bipolar Spectrum Disorder With Moderate-to-Severe Hypomanic Symptoms or Mild Manic Symptoms
Lindner Center of HOPE
NCT00277667
Peer-delivered and Technology-Assisted Integrated Illness Management and Recovery
Dartmouth-Hitchcock Medical Center
NCT04481737
Medication Adherence in Hypertensive Individuals With Bipolar Disorder
Case Western Reserve University
NCT02983877
Interpersonal and Social Rhythm Therapy for Adolescents With Bipolar Disorder
University of Washington
NCT00576355
Improving Adherence in Adolescents and Young Adults With Bipolar Disorder
Case Western Reserve University
NCT04348604
Mindfulness Based Cognitive Therapy for Youth With Anxiety at Risk for Bipolar Disorder
University of Cincinnati
NCT02090595
Equetro for the Treatment of Mania in Children Ages 6-12 With Bipolar Disorder
Massachusetts General Hospital
NCT00181870
Vitamin D Supplementation for Bipolar Depression
University of Massachusetts, Worcester
NCT01884844
Self Focus in Bipolar Disorder: A Functional Magnetic Resonance Imaging (fMRI) Study
Massachusetts General Hospital
NCT02253225
12- Week Open Label Treatment of Refractory Bipolar Depression
The University of Texas Health Science Center at San Antonio
NCT00223496
Bioequivalency Study of 300 mg Lithium Carbonate Under Fed Conditions
Roxane Laboratories
NCT00602394
A Double-Blind, Placebo-Controlled Study of Galantamine to Improve Cognitive Dysfunction in Bipolar Disorder
Cambridge Health Alliance
NCT00195845
Proactive Psychiatry Consultation for Patients With Cancer and Severe Mental Illness
Massachusetts General Hospital
NCT02594696
Acupuncture as a Supplemental Treatment for Bipolar Depression
University of Texas Southwestern Medical Center
NCT00071669
Functional Remediation for Bipolar Disorder
University of Michigan
NCT03403179
Lamotrigine in the Treatment of Bipolar Disorder in Women of Reproductive Age
Stanford University
NCT00238576
Bioequivalency Study of 450 mg Lithium Carbonate Under Fasting Conditions
Roxane Laboratories
NCT00602381
Bioequivalency Study of 300 mg Lithium Carbonate Under Fasting Conditions
Roxane Laboratories
NCT00601536
Lamictal As Add on Treatment in Mixed States of Bipolar Disorder
The University of Texas Health Science Center at San Antonio
NCT00223509
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 3 |
| Phase 2 | 12 |
| Phase 3 | 23 |
| Phase 4 | 22 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Bipolar Disorder Trial Landscape
163 indexed Bipolar Disorder studies · 37 recruiting (23%).
Phase mix: 45 late (III/IV) vs 15 early (I/II).
Top sponsor: Massachusetts General Hospital (11 trials), 9 others listed. 50 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Bipolar Disorder?
PlainTrial tracks 163 US clinical trials for Bipolar Disorder, of which 37 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Bipolar Disorder?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.