Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Bipolar Disorder: later-stage trial registry
37 of 163 indexed Bipolar Disorder trials are currently recruiting, with more weight in Phase 3-4.
Corpus placement: #66 of 28,707 conditions by registered trial count.
163 US clinical trials · 37 currently recruiting · #66 of 28,707 conditions by registered trial count
Bipolar Disorder: 163 US clinical trials tracked, 37 recruiting.
Bipolar Disorder is the subject of 163 registered US clinical trials on ClinicalTrials.gov, 37 of them currently open to new participants. 45 are in Phase 3-4 (later-stage) and 15 in Phase 1-2 (earlier-stage). The most active sponsor is Massachusetts General Hospital, running 11 of these trials.
Enrollment posture brief
Registry condition bipolar-disorder
OPEN 37 | RECR 23% | LATE 45 | EARLY 15 | RANK #66 | SPON 11
Volume-matched condition peers
Nearest open-share peer: Hypogonadism (23% recruiting · 22 trials)
Bipolar Disorder lists 37 open slots (23% of 163 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Bipolar Disorder on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
-
Bipolar Disorder is recruiting below its size-band peers.
37 of 163 indexed trials (22.7%) are open to enrollment, against a 37.1% average across 139 conditions with 100+ trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
-
Sponsorship of Bipolar Disorder trials is spread across many organizations.
Massachusetts General Hospital accounts for 11 of 163 trials (6.7%). 73 distinct sponsors appear on at least one study for this condition label.
-
Typical Bipolar Disorder enrolment sits around 75 participants.
Median target enrolment is 75 among the 163 trials that report a genuine target (sentinel values excluded). 92 of those (56.4%) plan for fewer than 100 participants.
-
Bipolar Disorder research is mostly interventional.
133 interventional and 30 observational studies make up this index (81.6% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
163 total, page 3 of 4
Disseminating Evidence-based Mood Disorder Chronic Care Models
University of Michigan
NCT01615458
A Pilot Study of Citicoline add-on Therapy in Patients With Bipolar Disorder or Major Depressive Disorder and Amphetamine Abuse or Dependence
University of Texas Southwestern Medical Center
NCT00377299
Acute Alcohol Response In Bipolar Disorder: a fMRI Study
University of Texas at Austin
NCT04063384
A Study of Risperidone Monotherapy in Bipolar Anxiety
University of South Florida
NCT00167479
Improving Care for Patients With Bipolar Disorder
University of Michigan
NCT00222755
Cornerstone Program for Transition-Age Youth Study Protocol for a Randomized Controlled Trial
New York University
NCT02696109
Evaluating the Effectiveness of Family-Focused Psychoeducation in Treating Adolescents With Bipolar Disorder
University of California, Los Angeles
NCT00571402
Insulin Resistance in Patients With Major Depression
Stanford University
NCT01106313
In-person vs. Remote Wellness Support
The University of Texas Health Science Center at San Antonio
NCT04526067
Neuromodulation for Enhancement of Emotion Regulation in Bipolar Mood Disorders
Massachusetts General Hospital
NCT04284267
Life Goals Behavioral Change to Improve Outcomes for Veterans With Serious Mental Illness
VA Office of Research and Development
NCT01244854
Imaging GABAergic/Glutamatergic Drugs in Bipolar Alcoholics Alcoholics
Medical University of South Carolina
NCT03220776
Double-blind, Placebo-Controlled Divalproex Sodium ER in Bipolar I or Bipolar II Depression
University Hospitals Cleveland Medical Center
NCT00194116
Effectiveness of Cognitive Behavioral Therapy for Treating Depression in People With Bipolar I Disorder
Massachusetts General Hospital
NCT00595387
Early Family-Focused Treatment for Youth at Risk for Bipolar Disorder
University of California, Los Angeles
NCT00943085
Sleep Disturbance and Bipolar Disorder
University of California, Berkeley
NCT00993850
Effectiveness of Two Self Assessment Tools: KIOS-Bipolar or eMoods
The University of Texas Health Science Center at San Antonio
NCT02418910
Modeling Mood Course to Detect Markers of Effective Adaptive Interventions
University of Wisconsin, Madison
NCT03358238
Omega-3 Dietary Supplements in Schizophrenia
Delbert Robinson
NCT01786239
Pediatric Bipolar Disorder Study at UCLA
University of California, Los Angeles
NCT00961935
Ziprasidone in Bipolar Disorder With Comorbid Lifetime Panic or Generalized Anxiety Disorder(GAD)
VA Palo Alto Health Care System
NCT01172652
Effectiveness of a Mobile Texting Intervention for People With Serious Mental Illness
University of Washington
NCT03062267
FMRI Study of Brain Response Before and After Lithium Treatment in People With Bipolar Disorder
Indiana University
NCT00596622
Placebo Controlled Trial of Valproate and Risperidone in Young Children With Bipolar Disorders
Children's Hospital Medical Center, Cincinnati
NCT00221403
Rostral Dorsal Cingulum Bundle Connectivity in Patients With Bipolar Disorder
University Hospitals Cleveland Medical Center
NCT02655978
Antipsychotics and Blood Vessel Function
Jess G. Fiedorowicz
NCT00585273
Customized Medication Adherence Enhancement for Adults With Bipolar Disorder
University Hospitals Cleveland Medical Center
NCT00830310
Clozapine for Treatment-Resistant Mania
National Institute of Mental Health (NIMH)
NCT00029458
Iloperidone in Mixed States of Bipolar Disorder
The University of Texas Health Science Center at San Antonio
NCT02413918
Understanding Treatment Adherence Among Individuals With Rapid Cycling Bipolar Disorder
Case Western Reserve University
NCT00183703
Prediction of Clinical Response to SSRI Treatment in Bipolar Disorder Using Serotonin 1A Receptor PET Imaging
New York State Psychiatric Institute
NCT02473250
Study of Quetiapine Monotherapy in Ambulatory Bipolar Spectrum Disorder With Moderate-to-Severe Hypomanic Symptoms or Mild Manic Symptoms
Lindner Center of HOPE
NCT00277667
Peer-delivered and Technology-Assisted Integrated Illness Management and Recovery
Dartmouth-Hitchcock Medical Center
NCT04481737
Medication Adherence in Hypertensive Individuals With Bipolar Disorder
Case Western Reserve University
NCT02983877
Interpersonal and Social Rhythm Therapy for Adolescents With Bipolar Disorder
University of Washington
NCT00576355
Improving Adherence in Adolescents and Young Adults With Bipolar Disorder
Case Western Reserve University
NCT04348604
Mindfulness Based Cognitive Therapy for Youth With Anxiety at Risk for Bipolar Disorder
University of Cincinnati
NCT02090595
Equetro for the Treatment of Mania in Children Ages 6-12 With Bipolar Disorder
Massachusetts General Hospital
NCT00181870
Vitamin D Supplementation for Bipolar Depression
University of Massachusetts, Worcester
NCT01884844
Self Focus in Bipolar Disorder: A Functional Magnetic Resonance Imaging (fMRI) Study
Massachusetts General Hospital
NCT02253225
12- Week Open Label Treatment of Refractory Bipolar Depression
The University of Texas Health Science Center at San Antonio
NCT00223496
Bioequivalency Study of 300 mg Lithium Carbonate Under Fed Conditions
Roxane Laboratories
NCT00602394
A Double-Blind, Placebo-Controlled Study of Galantamine to Improve Cognitive Dysfunction in Bipolar Disorder
Cambridge Health Alliance
NCT00195845
Proactive Psychiatry Consultation for Patients With Cancer and Severe Mental Illness
Massachusetts General Hospital
NCT02594696
Acupuncture as a Supplemental Treatment for Bipolar Depression
University of Texas Southwestern Medical Center
NCT00071669
Functional Remediation for Bipolar Disorder
University of Michigan
NCT03403179
Lamotrigine in the Treatment of Bipolar Disorder in Women of Reproductive Age
Stanford University
NCT00238576
Bioequivalency Study of 450 mg Lithium Carbonate Under Fasting Conditions
Roxane Laboratories
NCT00602381
Bioequivalency Study of 300 mg Lithium Carbonate Under Fasting Conditions
Roxane Laboratories
NCT00601536
Lamictal As Add on Treatment in Mixed States of Bipolar Disorder
The University of Texas Health Science Center at San Antonio
NCT00223509
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 3 |
| Phase 2 | 12 |
| Phase 3 | 23 |
| Phase 4 | 22 |
Top Sponsors
Named interventions
Most-linked intervention names on Bipolar Disorder records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Bipolar Disorder trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Bipolar Disorder page
163 registered trials, 37 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 37 Bipolar Disorder trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Massachusetts General Hospital sponsors the most Bipolar Disorder trials on record, review their full trial history before evaluating a specific study. See Massachusetts General Hospital's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Bipolar Disorder condition card totals 163 registered trials; most-linked intervention Placebo; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.