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NCT07266545 · ClinicalTrials.gov registry record · Phase 4

RNA Editing as a Biomarker of Antidepressant Response in Unipolar and Bipolar Depression (EDIT-ANDRE)

A Phase 4 study of Bipolar Depression and Unipolar Depression, sponsored by Mayo Clinic.

Recruiting
Registry status
Phase 4
Development phase
120
Enrollment target
1
Study location

NCT07266545 is a Phase 4 study of Bipolar Depression and Unipolar Depression that is actively recruiting participants, run by Mayo Clinic. The registered enrollment target is 120 participants, below the 212-participant average among 29 other Bipolar Depression trials with a reported enrollment target (43% lower). The trial reports 1 study location across 1 state.

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The verdict

NCT07266545, a Phase 4 study of Bipolar Depression and Unipolar Depression, is actively recruiting participants, sponsored by Mayo Clinic.

RECRUITING
Registry status
Phase 4
Development phase
120 participants
Enrollment target
1
Study location

Study Summary

The purpose of this research is to understand how changes in RNA editing relate to treatment response in unipolar and bipolar depression.

Conditions Studied

Bipolar Depression Unipolar Depression

Interventions

  • DRUG Vortioxetine
  • DRUG Bupropion extended release
  • DRUG Cariprazine (Augmentation Phase)

Study Locations (1)

Minnesota

  • Mayo Clinic in Rochester - Rochester

Trial Details

FieldValue
Enrollment Target 120 participants
Start Date 2026-02-17
Est. Completion 2030-12-31
Phase Phase 4

Sponsor

Mayo Clinic

2,844 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT07266545

The ClinicalTrials.gov registry entry for NCT07266545 describes a study currently listed as recruiting, categorized as Phase 4. The registered enrollment target is 120 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 212-participant average among 29 other Bipolar Depression trials with a reported enrollment target (43% lower). The listed sponsor is Mayo Clinic, which has 2,844 total studies on file at ClinicalTrials.gov.

The record links to 2 conditions, with Bipolar Depression appearing as the primary indexed condition, and to 3 interventions - of which Vortioxetine is the first listed.

NCT07266545 reports 1 study location spanning 1 distinct geographic area - top geographies include Minnesota.

Frequently Asked Questions

What is clinical trial NCT07266545 about?

NCT07266545 is a clinical study titled "RNA Editing as a Biomarker of Antidepressant Response in Unipolar and Bipolar Depression (EDIT-ANDRE)". The purpose of this research is to understand how changes in RNA editing relate to treatment response in unipolar and bipolar depression.

What is the current status of trial NCT07266545?

This trial is currently recruiting. It is a Phase 4 study. The enrollment target is 120 participants. The study started on 2026-02-17. Estimated completion is 2030-12-31.

What conditions does trial NCT07266545 study?

This clinical trial studies the following conditions: Bipolar Depression, Unipolar Depression.

What interventions are being tested in trial NCT07266545?

The interventions under investigation include: Vortioxetine (DRUG), Bupropion extended release (DRUG), Cariprazine (Augmentation Phase) (DRUG).

Who is sponsoring clinical trial NCT07266545?

This trial is sponsored by Mayo Clinic, which has 2,844 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT07266545 being conducted?

This trial has 1 study location across Minnesota. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

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Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.