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NCT06088732 · ClinicalTrials.gov registry record · Phase 1
Effects of Acute Exercise and Ibuprofen on Symptoms, Immunity, and Neural Circuits in Bipolar Depression
A Phase 1 study of Bipolar Depression, sponsored by Laureate Institute for Brain Research.
- Recruiting
- Registry status
- Phase 1
- Development phase
- 20
- Enrollment target
- 1
- Study location
NCT06088732: Recruiting Phase 1 study of Bipolar Depression, sponsored by Laureate Institute for Brain Research.
NCT06088732 is a Phase 1 study of Bipolar Depression that is actively recruiting participants, run by Laureate Institute for Brain Research. The registered enrollment target is 20 participants, below the 215-participant average among 29 other Bipolar Depression trials with a reported enrollment target (91% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06088732, a Phase 1 study of Bipolar Depression, is actively recruiting participants, sponsored by Laureate Institute for Brain Research.
- RECRUITING
- Registry status
- Phase 1
- Development phase
- 20 participants
- Enrollment target
- 1
- Study location
Study Summary
This is a 2x2, within-subjects, cross-over trial to test the anti-depressant effects of acute exercise in 20 participants with bipolar depression. Participants will complete four experimental sessions, two with an exercise challenge and two with a resting control condition in a counterbalanced order. Participants will receive either 800mg of ibuprofen or placebo before exercise or rest in order to test whether blocking the inflammatory response to exercise interferes with the neural and psychological effects of exercise.
Primary Outcome
Serum concentrations of interleukin 6 (IL-6)
Conditions Studied
Interventions
- DRUG Placebo
- OTHER Rest
- OTHER Exercise Session
- DRUG Ibuprofen 800 mg
Study Locations (1)
Oklahoma
- Laureate Institute for Brain Research - Tulsa
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 20 participants |
| Start Date | 2024-03-12 |
| Est. Completion | 2026-12-31 |
| Phase | Phase 1 |
What NCT06088732 shows while recruiting
NCT06088732 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 20 participants, a relatively small participant target, below the 215-participant average among 29 other Bipolar Depression trials with a reported enrollment target (91% lower).
The record links to 1 condition, with Bipolar Depression appearing as the primary indexed condition, and to 4 interventions - of which Placebo is the first listed.
NCT06088732 reports a single indexed study location in Oklahoma.
Frequently Asked Questions
What is clinical trial NCT06088732 about?
NCT06088732 is a clinical study titled "Effects of Acute Exercise and Ibuprofen on Symptoms, Immunity, and Neural Circuits in Bipolar Depression". This is a 2x2, within-subjects, cross-over trial to test the anti-depressant effects of acute exercise in 20 participants with bipolar depression. Participants will complete four experimental sessions, two with an exercise challenge and two with a resting control condition in a counterbalanced order...
What is the current status of trial NCT06088732?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 20 participants. The study started on 2024-03-12. Estimated completion is 2026-12-31.
What conditions does trial NCT06088732 study?
This clinical trial studies the following conditions: Bipolar Depression.
What interventions are being tested in trial NCT06088732?
The interventions under investigation include: Placebo (DRUG), Rest (OTHER), Exercise Session (OTHER), Ibuprofen 800 mg (DRUG).
Who is sponsoring clinical trial NCT06088732?
This trial is sponsored by Laureate Institute for Brain Research, which has 45 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06088732 being conducted?
This trial has 1 study location across Oklahoma. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Bipolar Depression
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06088732's enrollment target sits among peer trials
20 22nd of 29 higher than 3 of 29 other Bipolar Depression trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Bipolar Depression trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
-
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A Randomized Study of Azetukalner Versus Placebo in Depressive Episodes Associated With Bipolar I or II Disorder (Bipolar Depression)
RECRUITING · Phase 3
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