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ClinicalTrials.gov 12 recruiting now official registry

Back Pain clinical trials

12 of 38 indexed Back Pain trials are currently recruiting.

38 US clinical trials · 12 currently recruiting

Back Pain is the subject of 38 registered US clinical trials on ClinicalTrials.gov, 12 of them currently open to new participants. 6 are in Phase 3-4 (later-stage) and 4 in Phase 1-2 (earlier-stage). The most active sponsor is Brigham and Women's Hospital, running 3 of these trials.

The research picture

Back Pain has 38 registered US clinical trials, 12 of them open to new participants right now, about 32% of the total.

12
recruiting participants now
32%
of trials open to enrollment
6
in Phase 3–4 (later-stage)
3
top sponsor: Brigham and Women's Hospital
Phase 11Phase 23Phase 34Phase 42

Active & Recent Trials

38 total, page 1 of 1

RECRUITING 500 participants

VIA Disc NP Registry 3.0

VIVEX Biologics

NCT06345690

RECRUITING NA 460 participants

Moderators and Mediators (M & M Trial) of Psychosocial Treatments of Chronic Pain

Rush University Medical Center

NCT06044649

RECRUITING NA 376 participants

Partners4Pain & Wellbeing: A Randomized Trial of Community Supported Complementary and Integrative Health Self-management for Back Pain

University of Minnesota

NCT06696352

RECRUITING Phase 3 375 participants

CARES-Spine (Comprehensive Analgesic, Recovery, and Education Support for Spine Surgery) Trial

Stanford University

NCT06027099

RECRUITING NA 164 participants

Self-management of Low Back Pain in Horticulture Workers

University of Florida

NCT06153199

RECRUITING Phase 3 157 participants

Safety and Efficacy of Oral Cannabis in Chronic Spine Pain

University of Colorado, Denver

NCT05052541

RECRUITING NA 120 participants

Stress and Opioid Misuse Risk: The Role of Endogenous Opioid and Endocannabinoid Mechanisms

Vanderbilt University Medical Center

NCT05142267

RECRUITING Phase 2 80 participants

Cannabidiol for Reduction of Brain Neuroinflammation

Massachusetts General Hospital

NCT05066308

RECRUITING Phase 4 75 participants

Haloperidol for Pain Control in Patients With Acute Musculoskeletal Back Pain in the Emergency Department

Western Michigan University School of Medicine

NCT06395428

RECRUITING NA 60 participants

Post Marketing Study of MagnetOs Easypack Putty Standalone Compared to Demineralized Bone Matrix or Fibers Mixed With Autograft in Patients Undergoing Posterolateral Lumbar Fusion

Kuros Biosurgery

NCT04679844

RECRUITING NA 42 participants

Pain Intervention With Needling: Pilot Of Integrated Neuromodulation Techniques

The University of Texas Medical Branch, Galveston

NCT07112404

RECRUITING Phase 1 15 participants

Dose Escalation Pilot Study to Evaluate the Safety of Alocyte for the Treatment of Facetogenic Back Pain

Alimorad Farshchian

NCT05909709

ACTIVE NOT RECRUITING NA 230 participants

The RESET Clinical Trial: SPRINT® Peripheral Nerve Stimulation for the Treatment of Back Pain

SPR Therapeutics

NCT04246281

ACTIVE NOT RECRUITING 200 participants

Tissue Collection for Understanding Intervertebral Disc Degeneration and Back Pain

Northwell Health

NCT01633034

ACTIVE NOT RECRUITING NA 198 participants

Development of STEPPT

San Diego State University

NCT06835439

ACTIVE NOT RECRUITING NA 150 participants

Acceptability and Efficacy of Pain Reprocessing Therapy in Racially/ Ethnically Diverse Adults With Chronic Back Pain

University of Colorado, Denver

NCT05820204

ACTIVE NOT RECRUITING Phase 2 60 participants

Project 1 Aim 2, Adaptations of the Brain in Chronic Pain With Opioid Exposure

Northwestern University

NCT05463367

ACTIVE NOT RECRUITING Phase 2 40 participants

Testosterone Replacement to Alleviate Pain in Postmenopausal Women (TRAPP Trial)

Brigham and Women's Hospital

NCT04895306

COMPLETED NA 265 participants

Strategies for Prescribing Analgesics Comparative Effectiveness Trial

VA Office of Research and Development

NCT01583985

COMPLETED Phase 4 263 participants

ADAPT: Addressing Depression and Pain Together

University of Pittsburgh

NCT01124188

COMPLETED NA 212 participants

Evaluation the Impact of the "Pas" Technique Versus the "Standard" Technique on Radiation Exposure

Orthospine Advance Health

NCT06918197

COMPLETED NA 166 participants

Electrical Stimulation for the Treatment of Back Pain Using Peripheral Nerve Stimulation (PNS)

SPR Therapeutics

NCT03179202

COMPLETED 135 participants

Real-World Experience of Patients Treated for Musculoskeletal Injuries With SAM in Routine Care

ZetrOZ

NCT05254470

COMPLETED NA 127 participants

Telehealth Outreach for Chronic Back Pain

VA Office of Research and Development

NCT00608530

COMPLETED Phase 3 108 participants

Tapentadol IR vs Oxycodone IR vs Placebo in Acute Pain From Vertebral Compression Fracture Associated With Osteoporosis

Ortho-McNeil Janssen Scientific Affairs

NCT00771758

COMPLETED NA 101 participants

Spinal Cord Stimulator Implant Study

Duke University

NCT00887419

COMPLETED NA 100 participants

Evaluation of Efficacy and Comfort: A Trial on the Incrediwear Back Brace in Patients With Chronic Lower Back Pain

Johns Hopkins University

NCT06126887

COMPLETED NA 79 participants

Brain Mechanisms of Acupuncture Treatment in Chronic Low Back Pain

Brigham and Women's Hospital

NCT01595451

COMPLETED NA 71 participants

Combined Interventions for Treating Depression and Chronic Back Pain

Kaiser Permanente

NCT00158275

COMPLETED Phase 3 65 participants

An Implantable Spinal Cord Stimulation Pain Management System

Boston Scientific Corporation

NCT00205855

COMPLETED 60 participants

Muscle Activation Characteristics During Spinal Manipulation in Healthy and Low Back Pain Participants

University of Denver

NCT03483714

COMPLETED NA 45 participants

Perioperative ACT for Preventing CPSP: a Single-arm Non-randomized Pilot Trial

Samantha Meints

NCT06750874

COMPLETED NA 40 participants

Comparison of Activator Manipulation Versus Manual Side Posture Manipulation in Patients With Low Back Pain

Cleveland Chiropractic College

NCT00497861

COMPLETED NA 38 participants

Project Relief: Developing Brain Stimulation as a Treatment for Chronic Pain

Wake Forest University Health Sciences

NCT04156802

COMPLETED NA 33 participants

Comparing Sports Bra Design in Full Busted Women

University of Houston

NCT05456594

COMPLETED NA 32 participants

Cognitive Behavioral Therapy (CBT) Pain Prevention Intervention for Women Undergoing Surgery

Brigham and Women's Hospital

NCT06335485

COMPLETED NA 30 participants

Muscle Activity During Load Carriage in ROTC Cadets

North Dakota State University

NCT04744246

COMPLETED NA 8 participants

Microbreaks in the OR to Mitigate High Physical and Mental Demands

Mayo Clinic

NCT02565394

Phase Distribution

PhaseTrial count
Phase 1 1
Phase 2 3
Phase 3 4
Phase 4 2

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Back Pain Trial Landscape

38 indexed Back Pain studies · 12 recruiting (32%).

Phase mix: 6 late (III/IV) vs 4 early (I/II).

Top sponsor: Brigham and Women's Hospital (3 trials), 9 others listed. 38 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Back Pain?

PlainTrial tracks 38 US clinical trials for Back Pain, of which 12 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Back Pain?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.