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NCT04045990 · ClinicalTrials.gov registry record · NA
Network Modulation in Alzheimer's Disease
A NA study of Alzheimer Disease and Mild Cognitive Impairment, sponsored by Brigham and Women's Hospital.
- Completed
- Registry status
- NA
- Development phase
- 11
- Enrollment target
- 1
- Study location
NCT04045990 is a NA study of Alzheimer Disease and Mild Cognitive Impairment that has completed, run by Brigham and Women's Hospital. The registered enrollment target is 11 participants, below the 2,751-participant average among 306 other Alzheimer Disease trials with a reported enrollment target (100% lower). The trial reports 1 study location across 1 state.
The verdict
NCT04045990, a NA study of Alzheimer Disease and Mild Cognitive Impairment, has completed, sponsored by Brigham and Women's Hospital.
- COMPLETED
- Registry status
- NA
- Development phase
- 11 participants
- Enrollment target
- 1
- Study location
Study Summary
The purpose of this study is to assess the effects of non-invasive brain stimulation on memory and language ability in patients with two phenotypic variations of underlying Alzheimer disease pathology: amnestic mild cognitive impairment (aMCI) and logopenic variant of primary progressive aphasia (lvPPA). This study will use repetitive Transcranial Magnetic Stimulation (rTMS) to stimulate nodes of networks that are thought to be affected in these two conditions. Specifically, a node of the Default Mode Network (DMN)-the angular gyrus (AG)-will be stimulated in aMCI patients; and a node of the language network-the posterior inferior frontal gyrus (pIFG) will be stimulated in patients with lvPPA. We will use functional connectivity MRI (fcMRI) to assess changes in functional network architecture following the stimulation. We will also assess putative cognitive improvements resulting from the stimulation by in-depth language testing in lvPPA patients and in-depth memory testing in aMCI patients.
Conditions Studied
Interventions
- DEVICE repetitive transcranial magnetic stimulation (rTMS)
Study Locations (1)
Massachusetts
- Massachusetts General Hospital - Charlestown
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 11 participants |
| Start Date | 2018-09-01 |
| Est. Completion | 2022-03-01 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT04045990
The ClinicalTrials.gov registry entry for NCT04045990 describes a study currently listed as completed, categorized as NA. The registered enrollment target is 11 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 2,751-participant average among 306 other Alzheimer Disease trials with a reported enrollment target (100% lower). The listed sponsor is Brigham and Women's Hospital, which has 937 total studies on file at ClinicalTrials.gov.
The record links to 3 conditions, with Alzheimer Disease appearing as the primary indexed condition, and to 1 intervention - of which repetitive transcranial magnetic stimulation (rTMS) is the first listed.
NCT04045990 reports 1 study location spanning 1 distinct geographic area - top geographies include Massachusetts.
Frequently Asked Questions
What is clinical trial NCT04045990 about?
NCT04045990 is a clinical study titled "Network Modulation in Alzheimer's Disease". The purpose of this study is to assess the effects of non-invasive brain stimulation on memory and language ability in patients with two phenotypic variations of underlying Alzheimer disease pathology: amnestic mild cognitive impairment (aMCI) and logopenic variant of primary progressive aphasia (lv...
What is the current status of trial NCT04045990?
This trial is currently completed. It is a NA study. The enrollment target is 11 participants. The study started on 2018-09-01. Estimated completion is 2022-03-01.
What conditions does trial NCT04045990 study?
This clinical trial studies the following conditions: Alzheimer Disease, Mild Cognitive Impairment, Primary Progressive Aphasia.
What interventions are being tested in trial NCT04045990?
The interventions under investigation include: repetitive transcranial magnetic stimulation (rTMS) (DEVICE).
Who is sponsoring clinical trial NCT04045990?
This trial is sponsored by Brigham and Women's Hospital, which has 937 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04045990 being conducted?
This trial has 1 study location across Massachusetts. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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