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NCT04200911 · ClinicalTrials.gov registry record · Early Phase 1
Cognition, Age, and RaPamycin Effectiveness - DownregulatIon of thE mTor Pathway
A Early Phase 1 study of Alzheimer Disease and Cognitive Impairment, Mild, sponsored by The University of Texas Health Science Center at San Antonio.
- Completed
- Registry status
- Early Phase 1
- Development phase
- 10
- Enrollment target
- 1
- Study location
NCT04200911: Completed Early Phase 1 study of Alzheimer Disease and Cognitive Impairment, Mild, sponsored by The University of Texas Health Science Center at San Antonio.
NCT04200911 is a Early Phase 1 study of Alzheimer Disease and Cognitive Impairment, Mild that has completed, run by The University of Texas Health Science Center at San Antonio. The registered enrollment target is 10 participants, below the 2,751-participant average among 306 other Alzheimer Disease trials with a reported enrollment target (100% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04200911, a Early Phase 1 study of Alzheimer Disease and Cognitive Impairment, Mild, has completed, sponsored by The University of Texas Health Science Center at San Antonio.
- COMPLETED
- Registry status
- Early Phase 1
- Development phase
- 10 participants
- Enrollment target
- 1
- Study location
Study Summary
Evaluation of central nervous system penetration of orally administered Rapamune (RAPA) in older adults with Mild Cognitive Impairment (MCI) or early Alzheimer's disease (AD) and investigate associated safety, tolerability, target engagement, cognition, and functional status as initial proof-of-concept study
Primary Outcome
Lumbar punctures will be performed at baseline and after the final RAPA dose, to assess CSF levels of the drug. Change is calculated as value at 8 weeks minus the value at baseline.
Conditions Studied
Interventions
- DRUG Rapamune
Study Locations (1)
Texas
- UTHSA McDermott Clinical Sciences Building - San Antonio
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 10 participants |
| Start Date | 2020-06-01 |
| Est. Completion | 2022-01-13 |
| Phase | Early Phase 1 |
What the finished NCT04200911 record still lists
NCT04200911 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 10 participants, a relatively small participant target, below the 2,751-participant average among 306 other Alzheimer Disease trials with a reported enrollment target (100% lower).
The record links to 2 conditions, with Alzheimer Disease appearing as the primary indexed condition, and to 1 intervention - of which Rapamune is the first listed.
NCT04200911 reports a single indexed study location in Texas.
Frequently Asked Questions
What is clinical trial NCT04200911 about?
NCT04200911 is a clinical study titled "Cognition, Age, and RaPamycin Effectiveness - DownregulatIon of thE mTor Pathway". Evaluation of central nervous system penetration of orally administered Rapamune (RAPA) in older adults with Mild Cognitive Impairment (MCI) or early Alzheimer's disease (AD) and investigate associated safety, tolerability, target engagement, cognition, and functional status as initial proof-of-conc...
What is the current status of trial NCT04200911?
This trial is currently completed. It is a Early Phase 1 study. The enrollment target is 10 participants. The study started on 2020-06-01. Estimated completion is 2022-01-13.
What conditions does trial NCT04200911 study?
This clinical trial studies the following conditions: Alzheimer Disease, Cognitive Impairment, Mild.
What interventions are being tested in trial NCT04200911?
The interventions under investigation include: Rapamune (DRUG).
Who is sponsoring clinical trial NCT04200911?
This trial is sponsored by The University of Texas Health Science Center at San Antonio, which has 378 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04200911 being conducted?
This trial has 1 study location across Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Alzheimer Disease
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT04200911's enrollment target sits among peer trials
10 291st of 306 higher than 13 of 306 other Alzheimer Disease trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Alzheimer Disease trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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