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NCT00039702 · ClinicalTrials.gov registry record
Brain Imaging in Alzheimer's Disease
A clinical trial of Alzheimer Disease, sponsored by National Institute of Mental Health (NIMH).
- Completed
- Registry status
- 40
- Enrollment target
- 1
- Study location
NCT00039702: Completed study of Alzheimer Disease, sponsored by National Institute of Mental Health (NIMH).
NCT00039702 is a study of Alzheimer Disease that has completed, run by National Institute of Mental Health (NIMH). The registered enrollment target is 40 participants, below the 2,751-participant average among 306 other Alzheimer Disease trials with a reported enrollment target (99% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00039702, a study of Alzheimer Disease, has completed, sponsored by National Institute of Mental Health (NIMH).
- COMPLETED
- Registry status
- 40 participants
- Enrollment target
- 1
- Study location
Study Summary
The purpose of this study is to use brain imaging technology to examine the role of certain brain chemicals in individuals with Alzheimer's disease (AD) and in healthy volunteers. Cognitive dysfunction in people with AD is thought to arise from decreased chemical activity in specific parts of the brain. Decreases in alpha4beta2 nicotinic acetycholine receptors (nAChRs) have been found in the brains of people who died with AD; however, the status of this receptor system in living brains remains unclear. This study will use single photon emission computed tomography (SPECT) to study this receptor system in people with AD who have mild to moderate dementia and in healthy volunteers. In addition, this study will examine the relationship between cognitive dysfunction and nAChR deficits in the brains of individuals with AD. Participants with AD will have four clinic visits; healthy volunteers will have three visits. At Visit 1, participants will undergo a medical history, physical examination, and laboratory tests. Healthy volunteers will have a Mini-Mental State Examination (MMSE) cognitive function test. Participants with AD will have a MMSE and measurement of the severity of their dementia. During Visit 2, participants will undergo a magnetic resonance imaging (MRI) scan of the brain. At Visit 3, participants will undergo SPECT imaging. Only participants with AD will participate in Visit 4. During this visit, cognitive testing will be performed.
Conditions Studied
Interventions
- DRUG [123] 5-I-A-85380
Study Locations (1)
Maryland
- National Institute of Mental Health (NIMH) - Bethesda
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 40 participants |
| Start Date | 2002-06 |
| Est. Completion | 2004-09 |
What the finished NCT00039702 record still lists
NCT00039702 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 40 participants, a relatively small participant target, below the 2,751-participant average among 306 other Alzheimer Disease trials with a reported enrollment target (99% lower).
The record links to 1 condition, with Alzheimer Disease appearing as the primary indexed condition, and to 1 intervention - of which [123] 5-I-A-85380 is the first listed.
NCT00039702 reports a single indexed study location in Maryland.
Frequently Asked Questions
What is clinical trial NCT00039702 about?
NCT00039702 is a clinical study titled "Brain Imaging in Alzheimer's Disease". The purpose of this study is to use brain imaging technology to examine the role of certain brain chemicals in individuals with Alzheimer's disease (AD) and in healthy volunteers. Cognitive dysfunction in people with AD is thought to arise from decreased chemical activity in specific parts of the b...
What is the current status of trial NCT00039702?
This trial is currently completed. The enrollment target is 40 participants. The study started on 2002-06. Estimated completion is 2004-09.
What conditions does trial NCT00039702 study?
This clinical trial studies the following conditions: Alzheimer Disease.
What interventions are being tested in trial NCT00039702?
The interventions under investigation include: [123] 5-I-A-85380 (DRUG).
Who is sponsoring clinical trial NCT00039702?
This trial is sponsored by National Institute of Mental Health (NIMH), which has 343 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT00039702 being conducted?
This trial has 1 study location across Maryland. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Alzheimer Disease
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT00039702's enrollment target sits among peer trials
40 221st of 306 higher than 74 of 306 other Alzheimer Disease trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Alzheimer Disease trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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