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Alcoholism clinical trials
11 of 67 indexed Alcoholism trials are currently recruiting.
67 US clinical trials · 11 currently recruiting
Alcoholism is the subject of 67 registered US clinical trials on ClinicalTrials.gov, 11 of them currently open to new participants. 14 are in Phase 3-4 (later-stage) and 26 in Phase 1-2 (earlier-stage). The most active sponsor is National Institute on Alcohol Abuse and Alcoholism (NIAAA), running 11 of these trials.
The research picture
Alcoholism has 67 registered US clinical trials, 11 of them open to new participants right now, about 16% of the total.
- 11
- recruiting participants now
- 16%
- of trials open to enrollment
- 14
- in Phase 3–4 (later-stage)
- 11
- top sponsor: National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Active & Recent Trials
67 total, page 1 of 2
SMART-r: Substance Monitoring and Active Relapse Tracking Repository
National Institute on Drug Abuse (NIDA)
NCT06676059
Characterization Imaging Instruments in Alcoholics and Non-Alcoholics
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
NCT02108080
Behavioral and Functional Task Development, Implementation, and Testing
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
NCT02108054
Alcohol and the Social Brain: an Alcohol-Administration Hyperscanning Study
University of Illinois at Urbana-Champaign
NCT06687525
Alcohol and the Social Brain: An Alcohol-Administration Hyperscanning Study Employing a Within-Subject Design
University of Illinois at Urbana-Champaign
NCT07125534
CRP and S&A for Inpatient Veterans
VA Office of Research and Development
NCT05054738
Safety and Effectiveness of the BrainsWay Deep Transcranial Magnetic Stimulation (Deep TMS) for Treatment of Alcohol Use Disorder (AUD)
Brainsway
NCT07216872
Suicidal Behavior in Patients Diagnosed With Bipolar Disorder
Emory University
NCT02604277
Naltrexone in AUD Reward Drinkers
University of Pennsylvania
NCT05028062
Ketamine Alcohol (in Treatment-Resistant Depression)
Mark Niciu
NCT02122562
Developing Functional Connectivity-Guided TMS for Alcohol Use Disorder
VA Palo Alto Health Care System
NCT06415721
Chicago Social Drinking Project
University of Chicago
NCT00961792
Behavioral Alcohol Responses (BAR) Study
Carnegie Mellon University
NCT03467191
Stand Down-Think Before You Drink: An RCT of a Mobile App for Hazardous Drinking With Peer Phone Support
VA Office of Research and Development
NCT05473598
Telehealth Treatment for Alcohol Use Disorder
Ria Health
NCT05747703
Ibudilast for Treating Alcohol Use Disorder
University of Pennsylvania
NCT05414240
Ultra-brief Intervention for Problem Drinkers
Centre for Addiction and Mental Health
NCT00688584
COMBINE (Acamprosate/Naltrexone)
University of North Carolina, Chapel Hill
NCT00006206
The Effect of Positive and Negative Emotions on Brain Activity in Alcoholics and Nonalcoholics
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
NCT00001675
Acamprosate: Genes Associated With Response
Mayo Clinic
NCT00662571
Combined Pharmacotherapies for Alcoholism (Naltrexone/Ondansetron)
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
NCT00027079
A Randomized, Double-blind Placebo-Controlled Pharmacogenetic Study of Topiramate in European-American Heavy Drinkers
University of Pennsylvania
NCT02371889
Integrated Stepped Care for Unhealthy Alcohol Use in HIV
Yale University
NCT01410123
Managing Alcoholism in People Who Do Not Respond to Naltrexone
University of Pennsylvania
NCT00115037
Combination of Disulfiram Plus Naltrexone to Treat Both Cocaine- and Alcohol-dependent Individuals - 1
University of Pennsylvania
NCT00142844
Drug Therapy for Alcohol Dependence in Alaska Natives (Naltrexone/Sertraline)
Yale University
NCT00000451
Naltrexone, Craving, and Drinking
Brown University
NCT00006203
Individualized Assessment and Treatment for Alcoholism II
UConn Health
NCT03233802
Topiramate for Alcohol and Cocaine Dependence
Kyle Kampman
NCT00167245
Integrated Alcohol Disorder and PTSD Treatment
VA Office of Research and Development
NCT01601067
Adaptive Interventions for Problem Drinkers
Northwell Health
NCT02511808
Post-Treatment Effects of Naltrexone
Indiana University
NCT00006449
Gabapentin Treatment of Alcohol Dependence
The Scripps Research Institute
NCT00391716
Naltrexone for Heavy Drinking in Young Adults
Yale University
NCT00568958
Treatment With Mecamylamine in Smoking and Non-smoking Alcohol Dependent Patients
Yale University
NCT00342563
Sertraline Pharmacotherapy for Alcoholism Subtypes
UConn Health
NCT00368550
Chronic Alcohol and Brain Stress Circuit Response
Yale University
NCT01031264
Drug Treatment for Depressed Alcoholics (Naltrexone/Fluoxetine)
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
NCT00006204
Mifepristone Treatment of Alcohol Use Disorder
The Scripps Research Institute
NCT02179749
Imaging Cannabinoid CB1 Receptors in Alcohol Dependence
National Institute of Mental Health (NIMH)
NCT00816439
Naltrexone Treatment of Alcohol Abuse in Schizophrenia
State University of New York - Upstate Medical University
NCT00145847
The Effects of Oxytocin on Startle Hyperreactivity in Patients With AUD and PTSD
University of California, San Francisco
NCT02469259
A Study of LY2940094 in Participants With Alcohol Dependency
BlackThorn Therapeutics
NCT01798303
Matching Genotypes and Serotonergic Medications for Alcoholism
Brown University
NCT01113164
Aripiprazole for Bipolar Disorder and Alcohol Use Disorder
University of Texas Southwestern Medical Center
NCT02918370
GABA Mechanisms Underlying the Vulnerability to Alcohol Dependence
Yale University
NCT00611767
Repurposing alpha1 Noradrenergic Antagonists for Alcoholism Treatment
University of Wisconsin, Madison
NCT02966340
The Stress-Hormone System in Alcohol-Dependent Subjects
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NCT00536146
The Effect of Naltrexone on Alcohol Craving and on Brain Activity During Alcohol Infusion
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
NCT00667771
Effect of LY686017 on Alcohol Craving
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
NCT00310427
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 10 |
| Phase 2 | 16 |
| Phase 3 | 3 |
| Phase 4 | 11 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Alcoholism Trial Landscape
67 indexed Alcoholism studies · 11 recruiting (16%).
Phase mix: 14 late (III/IV) vs 26 early (I/II).
Top sponsor: National Institute on Alcohol Abuse and Alcoholism (NIAAA) (11 trials), 9 others listed. 50 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Alcoholism?
PlainTrial tracks 67 US clinical trials for Alcoholism, of which 11 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Alcoholism?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.