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ClinicalTrials.gov 7 recruiting now official registry

AL Amyloidosis clinical trials

7 of 16 indexed AL Amyloidosis trials are currently recruiting.

16 US clinical trials · 7 currently recruiting

AL Amyloidosis is the subject of 16 registered US clinical trials on ClinicalTrials.gov, 7 of them currently open to new participants. 4 are in Phase 3-4 (later-stage) and 10 in Phase 1-2 (earlier-stage). The most active sponsor is Alexion Pharmaceuticals, running 2 of these trials.

The research picture

AL Amyloidosis has 16 registered US clinical trials, 7 of them open to new participants right now, about 44% of the total.

7
recruiting participants now
44%
of trials open to enrollment
4
in Phase 3–4 (later-stage)
2
top sponsor: Alexion Pharmaceuticals
Phase 15Phase 25Phase 34

Active & Recent Trials

16 total, page 1 of 1

RECRUITING 5,000 participants

Ohio State University Multiple Myeloma and Amyloidosis Data Registry and Sample Resource

Ohio State University Comprehensive Cancer Center

NCT01408225

RECRUITING Phase 3 338 participants

Comparing Dara-VCD Chemotherapy Plus Stem Cell Transplant to Dara-VCD Chemotherapy Alone for People Who Have Newly Diagnosed AL Amyloidosis

SWOG Cancer Research Network

NCT06022939

RECRUITING Phase 3 200 participants

Efficacy of [18F]Florbetaben PET for Diagnosis of Cardiac AL Amyloidosis

Life Molecular Imaging

NCT05184088

RECRUITING Phase 2 96 participants

Daratumumab Maintenance Therapy for Improving Survival in Patients With Light Chain Amyloidosis, EMILIA Trial

Mayo Clinic

NCT05898646

RECRUITING Phase 1 53 participants

Venetoclax-Dexamethasone in Relapsed and/or Refractory t(11;14) Amyloidosis

Rajshekhar Chakraborty, MD

NCT05451771

RECRUITING Phase 1 49 participants

Elranatamab in Patients With Relapsed or Refractory AL Amyloidosis

Brigham and Women's Hospital

NCT06569147

RECRUITING Phase 1 37 participants

Phase 1/2a Study of Belantamab Mafodotin in Relapsed or Refractory AL Amyloidosis

University of Texas Southwestern Medical Center

NCT05145816

ACTIVE NOT RECRUITING Phase 3 281 participants

A Study to Evaluate the Efficacy and Safety of CAEL-101 in Patients With Mayo Stage IIIa AL Amyloidosis (CARES)

Alexion Pharmaceuticals

NCT04512235

ACTIVE NOT RECRUITING Phase 3 125 participants

A Study to Evaluate the Efficacy and Safety of CAEL-101 in Patients With Mayo Stage IIIb AL Amyloidosis (CARES)

Alexion Pharmaceuticals

NCT04504825

ACTIVE NOT RECRUITING Phase 2 30 participants

Siltuximab to Decrease Symptom Burden After Autologous Stem Cell Transplantation for Patients With Multiple Myeloma and AL Amyloidosis

Memorial Sloan Kettering Cancer Center

NCT03315026

ACTIVE NOT RECRUITING Phase 2 17 participants

Ixazomib Maintenance Study in Patients With AL Amyloidosis

Memorial Sloan Kettering Cancer Center

NCT03618537

ACTIVE NOT RECRUITING Phase 2 15 participants

Daratumumab, Pomalidomide, and Dexamethasone (DPd) in Relapsed/Refractory Light Chain Amyloidosis Patients Previously Exposed to Daratumumab

Weill Medical College of Cornell University

NCT04270175

ACTIVE NOT RECRUITING Phase 1 11 participants

Isatuximab as Upfront Therapy for the Treatment of High Risk AL Amyloidosis

Emory University

NCT04754945

COMPLETED Phase 2 40 participants

Bendamustine and Dexamethasone in Patients With Relapsed AL Amyloidosis

Columbia University

NCT01222260

COMPLETED Phase 1 38 participants

Radioimmunoimaging of AL Amyloidosis

University of Tennessee

NCT01409148

COMPLETED 37 participants

Monitoring of Early Disease Progression in Hereditary Transthyretin Amyloidosis

The Cleveland Clinic

NCT03431896

Phase Distribution

PhaseTrial count
Phase 1 5
Phase 2 5
Phase 3 4

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the AL Amyloidosis Trial Landscape

16 indexed AL Amyloidosis studies · 7 recruiting (44%).

Phase mix: 4 late (III/IV) vs 10 early (I/II).

Top sponsor: Alexion Pharmaceuticals (2 trials), 9 others listed. 16 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for AL Amyloidosis?

PlainTrial tracks 16 US clinical trials for AL Amyloidosis, of which 7 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for AL Amyloidosis?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.