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NCT05767671 · ClinicalTrials.gov registry record · NA
Macrophage Programing in Acute Lung Injury: MiniBAL
A NA study of Acute Respiratory Distress Syndrome and Ventilator Associated Pneumonia, sponsored by William Janssen, MD.
- Recruiting
- Registry status
- NA
- Development phase
- 56
- Enrollment target
- 1
- Study location
NCT05767671 is a NA study of Acute Respiratory Distress Syndrome and Ventilator Associated Pneumonia that is actively recruiting participants, run by William Janssen, MD. The registered enrollment target is 56 participants, below the 366-participant average among 31 other Acute Respiratory Distress Syndrome trials with a reported enrollment target (85% lower). The trial reports 1 study location across 1 state.
The verdict
NCT05767671, a NA study of Acute Respiratory Distress Syndrome and Ventilator Associated Pneumonia, is actively recruiting participants, sponsored by William Janssen, MD.
- RECRUITING
- Registry status
- NA
- Development phase
- 56 participants
- Enrollment target
- 1
- Study location
Study Summary
The goal of this observational clinical trial is to learn about the role white blood cells (macrophages) play in lung inflammation in people with Acute Respiratory Distress Syndrome (ARDS). The main questions it aims to answer are: 1. How does the immune system respond to different kinds of lung injury and inflammation and how do those processes differ from each other? 2. What roles do the cells that live in the lungs (macrophages) play in turning off inflammation? How does their role differ from other cells that are called to the lung to help repair injury (recruited macrophages)? 3. Will more frequent testing of lung cell samples help reduce the time it takes to start treatment for ventilator-associated pneumonia (VAP) and therefore reduce the rates of initial therapy failure? Participants will be in the intensive care unit (ICU) on a mechanical ventilator (machine that helps patients breathe) because they have ARDS or are on a mechanical ventilator for some other reason (control group). The following will happen: 1. Participants will be given 100% oxygen through the breathing machine (mechanical ventilator) for 3-5 minutes. This is called pre-oxygenation. 2. A lung specialist (pulmonologist), a member of Dr. Janssen's research team, or respiratory therapist will place small amount of saline into the lung using a long catheter going through the breathing tube. 3. The fluid will be removed with suction and will be sent to the laboratory for testing. 4. This will be repeated two more times over the course of 10 days, or less if participants are taken off of the ventilator. The procedure will be performed no more than three times. 5. Two nasal brushings will be taken from the participants' nose. 6. Approximately 3 tablespoons of blood will be removed by putting a needle into the participants vein. This is the standard method used to obtain blood for tests. A total of 9 tablespoons will be taken for research purposes over the course of this study 7. Data including
Conditions Studied
Interventions
- OTHER Non-Bronchoscopic Mini Bronchoalveolar Lavage
Study Locations (1)
Colorado
- Intermountain Health - St. Joseph's Hospital - National Jewish Health - Denver
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 56 participants |
| Start Date | 2020-04-10 |
| Est. Completion | 2027-12-30 |
| Phase | NA |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT05767671
The ClinicalTrials.gov registry entry for NCT05767671 describes a study currently listed as recruiting, categorized as NA. The registered enrollment target is 56 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 366-participant average among 31 other Acute Respiratory Distress Syndrome trials with a reported enrollment target (85% lower). The listed sponsor is William Janssen, MD, which has 1 total studies on file at ClinicalTrials.gov.
The record links to 2 conditions, with Acute Respiratory Distress Syndrome appearing as the primary indexed condition, and to 1 intervention - of which Non-Bronchoscopic Mini Bronchoalveolar Lavage is the first listed.
NCT05767671 reports 1 study location spanning 1 distinct geographic area - top geographies include Colorado.
Frequently Asked Questions
What is clinical trial NCT05767671 about?
NCT05767671 is a clinical study titled "Macrophage Programing in Acute Lung Injury: MiniBAL". The goal of this observational clinical trial is to learn about the role white blood cells (macrophages) play in lung inflammation in people with Acute Respiratory Distress Syndrome (ARDS). The main questions it aims to answer are: 1. How does the immune system respond to different kinds of lung in...
What is the current status of trial NCT05767671?
This trial is currently recruiting. It is a NA study. The enrollment target is 56 participants. The study started on 2020-04-10. Estimated completion is 2027-12-30.
What conditions does trial NCT05767671 study?
This clinical trial studies the following conditions: Acute Respiratory Distress Syndrome, Ventilator Associated Pneumonia.
What interventions are being tested in trial NCT05767671?
The interventions under investigation include: Non-Bronchoscopic Mini Bronchoalveolar Lavage (OTHER).
Who is sponsoring clinical trial NCT05767671?
This trial is sponsored by William Janssen, MD, which has 1 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05767671 being conducted?
This trial has 1 study location across Colorado. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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