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NCT06690801 · ClinicalTrials.gov registry record
Dead Space and Inhaled Nitric Oxide in Pediatric Acute Respiratory Distress Syndrome
A clinical trial of Acute Respiratory Distress Syndrome, sponsored by Children's Hospital Los Angeles.
- Recruiting
- Registry status
- 1,260
- Enrollment target
- 10
- Study locations
NCT06690801 is a study of Acute Respiratory Distress Syndrome that is actively recruiting participants, run by Children's Hospital Los Angeles. The registered enrollment target is 1,260 participants, above the 327-participant average among 31 other Acute Respiratory Distress Syndrome trials with a reported enrollment target (285% higher). The trial reports 10 study locations across 9 states.
The verdict
NCT06690801, a study of Acute Respiratory Distress Syndrome, is actively recruiting participants, sponsored by Children's Hospital Los Angeles.
- RECRUITING
- Registry status
- 1,260 participants
- Enrollment target
- 10
- Study locations
Study Summary
The goal of this observational study is to determine whether a marker of dead space (the end-tidal to alveolar dead space fraction \[AVDSf\]) is more strongly associated with mortality risk than markers of oxygenation abnormality (oxygenation index) and to determine whether dead space (AVDSf) is an important marker of heterogeneity in the inhaled nitric oxide (iNO) treatment effect for children with acute respiratory distress syndrome (ARDS). The study aims are: 1. To validate AVDSf for risk stratification of mortality in pediatric ARDS 2. To determine if there is heterogeneity in treatment effect for iNO defined by AVDSf 3. To detect the association between AVDSf and microvascular dysfunction trajectory and whether iNO therapy modifies this association This is a prospective, multicenter observational study of 1260 mechanically ventilated children with moderate to severe ARDS. In a subgroup of 450 children with severe ARDS, longitudinal blood samples will be obtained to measure plasma protein markers.
Conditions Studied
Study Locations (10)
Wisconsin
- American Family Children's Hospital / University of Wisconsin-Madison - Madison
- Children's Hospital of Wisconsin / Medical College of Wisconsin - Milwaukee
California
- Children's Hospital Los Angeles - Los Angeles
Colorado
- Children's Hospital Colorado - Denver
Massachusetts
- Boston Children's Hospital - Boston
Michigan
- University of Michigan / CS Mott Children's Hospital - Ann Arbor
Nebraska
- University of Nebraska Medical Center / Children's Hospital and Medical Center - Omaha
Ohio
- Cincinnati Children's Hospital Medical Center - Cincinnati
Pennsylvania
- Children's Hospital of Philadelphia - Philadelphia
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 1,260 participants |
| Start Date | 2024-10-03 |
| Est. Completion | 2029-02-01 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06690801
The ClinicalTrials.gov registry entry for NCT06690801 describes a study currently listed as recruiting, categorized as an unspecified phase. The registered enrollment target is 1,260 participants, a figure that helps gauge the scale of data the investigators plan to collect, above the 327-participant average among 31 other Acute Respiratory Distress Syndrome trials with a reported enrollment target (285% higher). The listed sponsor is Children's Hospital Los Angeles, which has 119 total studies on file at ClinicalTrials.gov.
The record links to 1 condition, with Acute Respiratory Distress Syndrome appearing as the primary indexed condition, and to 0 interventions.
NCT06690801 reports 10 study locations spanning 9 distinct geographic areas - top geographies include Wisconsin, California, Colorado.
Frequently Asked Questions
What is clinical trial NCT06690801 about?
NCT06690801 is a clinical study titled "Dead Space and Inhaled Nitric Oxide in Pediatric Acute Respiratory Distress Syndrome". The goal of this observational study is to determine whether a marker of dead space (the end-tidal to alveolar dead space fraction \[AVDSf\]) is more strongly associated with mortality risk than markers of oxygenation abnormality (oxygenation index) and to determine whether dead space (AVDSf) is an ...
What is the current status of trial NCT06690801?
This trial is currently recruiting. The enrollment target is 1,260 participants. The study started on 2024-10-03. Estimated completion is 2029-02-01.
What conditions does trial NCT06690801 study?
This clinical trial studies the following conditions: Acute Respiratory Distress Syndrome.
Who is sponsoring clinical trial NCT06690801?
This trial is sponsored by Children's Hospital Los Angeles, which has 119 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06690801 being conducted?
This trial has 10 study locations across California, Colorado, Massachusetts, Michigan, Nebraska. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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Read our methodology - how this data is sourced, computed, and verified.
Related
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