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Dead Space and Inhaled Nitric Oxide in Pediatric Acute Respiratory Distress Syndrome
NCT06690801 · View on ClinicalTrials.gov ↗
Study Summary
The goal of this observational study is to determine whether a marker of dead space (the end-tidal to alveolar dead space fraction \[AVDSf\]) is more strongly associated with mortality risk than markers of oxygenation abnormality (oxygenation index) and to determine whether dead space (AVDSf) is an important marker of heterogeneity in the inhaled nitric oxide (iNO) treatment effect for children with acute respiratory distress syndrome (ARDS). The study aims are: 1. To validate AVDSf for risk stratification of mortality in pediatric ARDS 2. To determine if there is heterogeneity in treatment effect for iNO defined by AVDSf 3. To detect the association between AVDSf and microvascular dysfunction trajectory and whether iNO therapy modifies this association This is a prospective, multicenter observational study of 1260 mechanically ventilated children with moderate to severe ARDS. In a subgroup of 450 children with severe ARDS, longitudinal blood samples will be obtained to measure plasma protein markers.
Conditions Studied
Study Locations (10)
Wisconsin
- American Family Children's Hospital / University of Wisconsin-Madison — Madison
- Children's Hospital of Wisconsin / Medical College of Wisconsin — Milwaukee
California
- Children's Hospital Los Angeles — Los Angeles
Colorado
- Children's Hospital Colorado — Denver
Massachusetts
- Boston Children's Hospital — Boston
Michigan
- University of Michigan / CS Mott Children's Hospital — Ann Arbor
Nebraska
- University of Nebraska Medical Center / Children's Hospital and Medical Center — Omaha
Ohio
- Cincinnati Children's Hospital Medical Center — Cincinnati
Pennsylvania
- Children's Hospital of Philadelphia — Philadelphia
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 1,260 participants |
| Start Date | 2024-10-03 |
| Est. Completion | 2029-02-01 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06690801
The ClinicalTrials.gov registry entry for NCT06690801 describes a study currently listed as recruiting. It is categorized as an unspecified phase, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 1,260 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Children's Hospital Los Angeles, which has 163 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with Acute Respiratory Distress Syndrome appearing as the primary indexed condition, and to 0 interventions. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT06690801 reports 10 study locations spanning 9 distinct geographic areas — top geographies include Wisconsin, California, Colorado. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT06690801 about?
NCT06690801 is a clinical study titled "Dead Space and Inhaled Nitric Oxide in Pediatric Acute Respiratory Distress Syndrome". The goal of this observational study is to determine whether a marker of dead space (the end-tidal to alveolar dead space fraction \[AVDSf\]) is more strongly associated with mortality risk than markers of oxygenation abnormality (oxygenation index) and to determine whether dead space (AVDSf) is an ...
What is the current status of trial NCT06690801?
This trial is currently recruiting. The enrollment target is 1,260 participants. The study started on 2024-10-03. Estimated completion is 2029-02-01.
What conditions does trial NCT06690801 study?
This clinical trial studies the following conditions: Acute Respiratory Distress Syndrome. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
Who is sponsoring clinical trial NCT06690801?
This trial is sponsored by Children's Hospital Los Angeles, which has 163 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT06690801 being conducted?
This trial has 10 study locations across California, Colorado, Massachusetts, Michigan, Nebraska. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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