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ClinicalTrials.gov 159 recruiting now official registry

Acute Myeloid Leukemia clinical trials

159 of 307 indexed Acute Myeloid Leukemia trials are currently recruiting.

307 US clinical trials · 159 currently recruiting

Acute Myeloid Leukemia is the subject of 307 registered US clinical trials on ClinicalTrials.gov, 159 of them currently open to new participants. 13 are in Phase 3-4 (later-stage) and 265 in Phase 1-2 (earlier-stage). The most active sponsor is M.D. Anderson Cancer Center, running 38 of these trials.

The research picture

Acute Myeloid Leukemia has 307 registered US clinical trials, 159 of them open to new participants right now, about 52% of the total.

159
recruiting participants now
52%
of trials open to enrollment
13
in Phase 3–4 (later-stage)
38
top sponsor: M.D. Anderson Cancer Center
Phase 1160Phase 2105Phase 312Phase 41

Active & Recent Trials

307 total, page 6 of 7

COMPLETED Phase 2 255 participants

A Study To Evaluate PF-04449913 With Chemotherapy In Patients With Acute Myeloid Leukemia or Myelodysplastic Syndrome

Pfizer

NCT01546038

COMPLETED Phase 3 233 participants

IV Busulfan With Allo-BMT: Study for Patients With Acute Myelogenous Leukemia and Myelodysplastic Syndrome

M.D. Anderson Cancer Center

NCT00469144

COMPLETED Phase 2 211 participants

A Study of Lintuzumab (SGN-33) in Combination With Low Dose Cytarabine in Patients 60+ Years With AML

Seagen

NCT00528333

COMPLETED Phase 2 165 participants

Decitabine With or Without Bortezomib in Treating Older Patients With Acute Myeloid Leukemia

National Cancer Institute (NCI)

NCT01420926

COMPLETED Early Phase 1 130 participants

Evaluation of Antibody Response to High-Dose Seasonal Influenza Vaccination in Patients With Myeloid Malignancy Receiving Chemotherapy and Healthy Volunteers

Roswell Park Cancer Institute

NCT04484532

COMPLETED 120 participants

Clinical Factors Associated With the Development of Severe Sepsis in Patients Being Treated for Acute Myeloid Leukemia

Ohio State University

NCT00806325

COMPLETED Phase 2 116 participants

A Study of Clofarabine for Older Patients With Newly Diagnosed Acute Myelogenous Leukemia (AML) (CLASSIC II)

Genzyme, a Sanofi Company

NCT00373529

COMPLETED Phase 2 113 participants

Study of Voreloxin (Vosaroxin) in Older Patients With Untreated Acute Myeloid Leukemia

Sunesis Pharmaceuticals

NCT00607997

COMPLETED Phase 1 110 participants

Safety and Tolerability Study of Voreloxin and Cytarabine Combination in Acute Myeloid Leukemia in Humans

Sunesis Pharmaceuticals

NCT00541866

COMPLETED Phase 2 84 participants

Brentuximab Vedotin in Patients With CD30-positive Nonlymphomatous Malignancies

Seagen

NCT01461538

COMPLETED Phase 1 80 participants

A Study of ASP2215 in Combination With Induction and Consolidation Chemotherapy in Patients With Newly Diagnosed Acute Myeloid Leukemia

Astellas Pharma Global Development

NCT02236013

COMPLETED Phase 2 73 participants

Donor Umbilical Cord Blood Transplant in Treating Patients With Hematologic Cancer

Fred Hutchinson Cancer Center

NCT00723099

COMPLETED Phase 2 72 participants

Busulfan, Fludarabine, Clofarabine With Allogeneic Stem Cell Transplantation for Acute Myeloid Leukemia

M.D. Anderson Cancer Center

NCT00469014

COMPLETED Phase 2 61 participants

Combination Chemotherapy and Dasatinib in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia

National Cancer Institute (NCI)

NCT01238211

COMPLETED Phase 2 60 participants

Standard of Care +/- Midostaurin to Prevent Relapse Post Stem Cell Transplant in Patients With FLT3-ITD Mutated AML

Novartis Pharmaceuticals

NCT01883362

COMPLETED Phase 2 56 participants

CPX-351 in Treating Patients With Newly Diagnosed, High-Risk Acute Myeloid Leukemia

M.D. Anderson Cancer Center

NCT02286726

COMPLETED 56 participants

Shotgun Sequencing in Diagnosing Febrile Neutropenia in Patients With Acute Myeloid Leukemia

Stanford University

NCT02856204

COMPLETED Phase 1 55 participants

Safety Study of ALRN-6924 in Patients With Acute Myeloid Leukemia or Advanced Myelodysplastic Syndrome

Aileron Therapeutics

NCT02909972

COMPLETED Phase 1 54 participants

Study of Bexarotene in Patients With Acute Myeloid Leukemia

Abramson Cancer Center at Penn Medicine

NCT00316030

COMPLETED Phase 1 51 participants

Idarubicin + Cytarabine and Lenalidomide in Patients With Myelodysplastic Syndrome (MDS), Acute Myeloid Leukemia (AML)

H. Lee Moffitt Cancer Center and Research Institute

NCT00831766

COMPLETED Phase 2 51 participants

INCB018424 in Patients With Advanced Hematologic Malignancies

M.D. Anderson Cancer Center

NCT00674479

COMPLETED Phase 1 50 participants

Combination 5-azacitidine and Gemtuzumab Ozogamicin Therapy for Treatment of Relapsed Acute Myeloid Leukemia (AML)

University of California, San Diego

NCT00766116

COMPLETED 50 participants

Ascorbic Acid Levels in MDS, AML, and CMML Patients

Van Andel Research Institute

NCT03526666

COMPLETED Phase 1 50 participants

Pomalidomide After Combination Chemotherapy in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia or High-Risk Myelodysplastic Syndrome

National Cancer Institute (NCI)

NCT02029950

COMPLETED Phase 2 46 participants

T Cell Depletion for Recipients of HLA Haploidentical Related Donor Stem Cell Grafts

Baylor College of Medicine

NCT00368355

COMPLETED Phase 1 45 participants

Safety Study of Human Myeloid Progenitor Cells (CLT-008) After Chemotherapy for Leukemia

Cellerant Therapeutics

NCT01297543

COMPLETED NA 40 participants

Effects of Prebiotics on Gut Microbiome in Patients Undergoing HSCT

University of Virginia

NCT04629430

COMPLETED Phase 2 40 participants

HLA-Nonidentical Stem Cell and Natural Killer Cell Transplantation for Children Less the Two Years of Age With Hematologic Malignancies

St. Jude Children's Research Hospital

NCT00145626

COMPLETED Phase 1 40 participants

A Study Evaluating the Safety and Pharmacology of Atezolizumab Administered in Combination With Immunomodulatory Agents in Participants With Acute Myeloid Leukemia (AML)

Hoffmann-La Roche

NCT02892318

COMPLETED Phase 1 36 participants

Study of 72-Hour Infusion of ON 01910.Na in Patients With MDS or AML

Traws Pharma

NCT00854945

COMPLETED Phase 1 36 participants

A Phase 1b Study Evaluating AMG 232 Alone and in Combination With Trametinib in Acute Myeloid Leukemia

Kartos Therapeutics

NCT02016729

COMPLETED Phase 2 30 participants

Crenolanib Maintenance Following Allogeneic Stem Cell Transplantation in FLT3-positive Acute Myeloid Leukemia Patients

Arog Pharmaceuticals

NCT02400255

COMPLETED Phase 1 28 participants

Study of Crenolanib Combined With Chemotherapy in FLT3-mutated Acute Myeloid Leukemia Patients

Arog Pharmaceuticals

NCT02400281

COMPLETED Phase 2 25 participants

Phase II Study of Azacitidine and Sargramostim as Maintenance Treatment for Poor-Risk AML or MDS

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

NCT01700673

COMPLETED Phase 2 25 participants

NK Cell Based Non-Myeloablative Transplantation in Acute Myeloid Diseases

Masonic Cancer Center, University of Minnesota

NCT01370213

COMPLETED Phase 2 24 participants

Off-the-shelf NK Cells + SCT for Myeloid Malignancies

M.D. Anderson Cancer Center

NCT05115630

COMPLETED Phase 1 23 participants

IDH2 Inhibition Using Enasidenib as Maintenance Therapy for IDH2-mutant Myeloid Neoplasms Following Allogeneic Stem Cell Transplantation

Massachusetts General Hospital

NCT03515512

COMPLETED Phase 1 22 participants

Sorafenib Maintenance Therapy for Patients With AML After Allogeneic Stem Cell Transplant

Massachusetts General Hospital

NCT01398501

COMPLETED Phase 2 22 participants

Total Body Irradiation +/- Total Lymphoid Irradiation & Anti-Thymocyte Globulin in Non-myeloablative Hematopoietic Cell Transplantation

Stanford University

NCT03734601

COMPLETED Phase 1 21 participants

A Study of Selinexor in Combination With Daunorubicin and Cytarabine for Untreated AML

H. Lee Moffitt Cancer Center and Research Institute

NCT02403310

COMPLETED Phase 1 18 participants

Low-Dose Daunorubicin in Relapsed/Refractory Acute Leukemia

Tara Lin

NCT02914977

COMPLETED Phase 2 18 participants

CD8+ Memory T-Cells as Consolidative Therapy After Donor Non-myeloablative Hematopoietic Cell Transplant in Treating Patients With Leukemia or Lymphoma

Robert Lowsky

NCT02424968

COMPLETED Phase 1 17 participants

LY3214996 in Patients With AML Who Are Not Candidates for Standard Therapy

Dana-Farber Cancer Institute

NCT04081259

COMPLETED Phase 1 16 participants

KPT-9274 in Patients With Relapsed and Refractory Acute Myeloid Leukemia

University of Colorado, Denver

NCT04914845

COMPLETED Phase 2 16 participants

Phase II Study of the Combination of Mitoxantrone, Etoposide and Gemtuzumab Ozogamicin (MEGO) for Patients With Acute Myeloid Leukemia Refractory to Initial Standard Induction Therapy

Robert Redner, MD

NCT03839446

COMPLETED Phase 2 15 participants

Multicenter Phase II of CD26 Using Sitagliptin for Engraftment After UBC Transplant

Sherif S. Far

NCT01720264

COMPLETED Phase 2 14 participants

Multi-Ctr PII Cmb.Modality Tx Ruxolitinib, Decitabine, and DLI for Post HSCT in AML/MDS

Masonic Cancer Center, University of Minnesota

NCT04055844

COMPLETED Phase 1 14 participants

Targeted Marrow Irradiation, Fludarabine Phosphate, and Busulfan Before Donor Progenitor Cell Transplant in Treating Patients With Hematologic Malignancies

Case Comprehensive Cancer Center

NCT02129582

COMPLETED Phase 2 12 participants

A Study of E7820 in People With Bone Marrow (Myeloid) Cancers

Memorial Sloan Kettering Cancer Center

NCT05024994

COMPLETED Phase 1 10 participants

Infusion of Specially Treated Umbilical Cord Stem Cells After Chemoradiation Treatment for Blood Cancers

ViaCell

NCT00089596

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Phase Distribution

PhaseTrial count
Phase 1 160
Phase 2 105
Phase 3 12
Phase 4 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Acute Myeloid Leukemia Trial Landscape

307 indexed Acute Myeloid Leukemia studies · 159 recruiting (52%).

Phase mix: 13 late (III/IV) vs 265 early (I/II).

Top sponsor: M.D. Anderson Cancer Center (38 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Acute Myeloid Leukemia?

PlainTrial tracks 307 US clinical trials for Acute Myeloid Leukemia, of which 159 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Acute Myeloid Leukemia?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.