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NCT01398501 · ClinicalTrials.gov registry record · Phase 1
Sorafenib Maintenance Therapy for Patients With AML After Allogeneic Stem Cell Transplant
A Phase 1 study of Acute Myeloid Leukemia, sponsored by Massachusetts General Hospital.
- Completed
- Registry status
- Phase 1
- Development phase
- 22
- Enrollment target
- 2
- Study locations
NCT01398501: Completed Phase 1 study of Acute Myeloid Leukemia, sponsored by Massachusetts General Hospital.
NCT01398501 is a Phase 1 study of Acute Myeloid Leukemia that has completed, run by Massachusetts General Hospital. The registered enrollment target is 22 participants, below the 116-participant average among 306 other Acute Myeloid Leukemia trials with a reported enrollment target (81% lower). The trial reports 2 study locations across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01398501, a Phase 1 study of Acute Myeloid Leukemia, has completed, sponsored by Massachusetts General Hospital.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 22 participants
- Enrollment target
- 2
- Study locations
Study Summary
Sorfenib works by slowing the spread of cancer cells. It has been used in other studies for patients with AML with the FLT3-ITD mutation and information from these studies suggests that sorafenib may help to control leukemia. The purpose of this study is to find the highest dose of sorafenib for maintenance therapy that can be safely used in participants with AML who have undergone allogeneic stem cell transplant.
Primary Outcome
To define the maximum tolerated dose (MTD) of maintenance sorafenib after allogeneic HSCT
Conditions Studied
Interventions
- DRUG Sorafenib
Study Locations (2)
Massachusetts
- Massachusetts General Hospital - Boston
- Dana-Farber Cancer Institute - Boston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 22 participants |
| Start Date | 2011-08 |
| Est. Completion | 2016-08 |
| Phase | Phase 1 |
What the finished NCT01398501 record still lists
NCT01398501 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 22 participants, a relatively small participant target, below the 116-participant average among 306 other Acute Myeloid Leukemia trials with a reported enrollment target (81% lower).
The record links to 1 condition, with Acute Myeloid Leukemia appearing as the primary indexed condition, and to 1 intervention - of which Sorafenib is the first listed.
NCT01398501 reports a single indexed study location in Massachusetts.
Frequently Asked Questions
What is clinical trial NCT01398501 about?
NCT01398501 is a clinical study titled "Sorafenib Maintenance Therapy for Patients With AML After Allogeneic Stem Cell Transplant". Sorfenib works by slowing the spread of cancer cells. It has been used in other studies for patients with AML with the FLT3-ITD mutation and information from these studies suggests that sorafenib may help to control leukemia. The purpose of this study is to find the highest dose of sorafenib for mai...
What is the current status of trial NCT01398501?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 22 participants. The study started on 2011-08. Estimated completion is 2016-08.
What conditions does trial NCT01398501 study?
This clinical trial studies the following conditions: Acute Myeloid Leukemia.
What interventions are being tested in trial NCT01398501?
The interventions under investigation include: Sorafenib (DRUG).
Who is sponsoring clinical trial NCT01398501?
This trial is sponsored by Massachusetts General Hospital, which has 2,032 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT01398501 being conducted?
This trial has 2 study locations across Massachusetts. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT01398501's enrollment target sits among peer trials
22 236th of 306 higher than 64 of 306 other Acute Myeloid Leukemia trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Acute Myeloid Leukemia trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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