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COMPLETED Phase 2

Combination Chemotherapy and Dasatinib in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia

NCT01238211 · View on ClinicalTrials.gov ↗

Study Summary

This phase II trial studies the side effects and how well giving combination chemotherapy together with dasatinib works in treating patients with newly diagnosed acute myeloid leukemia. Drugs used in chemotherapy, such as daunorubicin hydrochloride and cytarabine, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Dasatinib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Giving combination chemotherapy together with dasatinib may kill more cancer cells.

Interventions

  • OTHER Laboratory Biomarker Analysis
  • DRUG Cytarabine
  • DRUG Dasatinib
  • DRUG Daunorubicin Hydrochloride

Study Locations (20)

Illinois

  • Saint Joseph Medical Center — Bloomington
  • Illinois CancerCare-Bloomington — Bloomington
  • Graham Hospital Association — Canton
  • Illinois CancerCare-Canton — Canton
  • Memorial Hospital — Carthage
  • University of Illinois — Chicago
  • University of Chicago Comprehensive Cancer Center — Chicago
  • Heartland Cancer Research NCORP — Decatur
  • Eureka Hospital — Eureka
  • Illinois CancerCare-Eureka — Eureka
  • Illinois CancerCare-Galesburg — Galesburg
  • Mason District Hospital — Havana
  • Illinois CancerCare-Macomb — Macomb
  • Mcdonough District Hospital — Macomb
  • Bromenn Regional Medical Center — Normal
  • Carle Cancer Institute Normal — Normal
  • Illinois CancerCare-Community Cancer Center — Normal

Delaware

  • Beebe Medical Center — Lewes
  • Christiana Care Health System-Christiana Hospital — Newark

Florida

  • AdventHealth Orlando — Orlando

Trial Details

FieldValue
Enrollment Target 61 participants
Start Date 2010-12-14
Est. Completion 2021-03-15
Phase Phase 2

Sponsor

National Cancer Institute (NCI)

2,390 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT01238211

The ClinicalTrials.gov registry entry for NCT01238211 describes a study currently listed as completed. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 61 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is National Cancer Institute (NCI), which has 2,390 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 8 conditions, with Acute Myeloid Leukemia appearing as the primary indexed condition, and to 4 interventions — of which Laboratory Biomarker Analysis is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT01238211 reports 20 study locations spanning 3 distinct geographic areas — top geographies include Illinois, Delaware, Florida. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT01238211 about?

NCT01238211 is a clinical study titled "Combination Chemotherapy and Dasatinib in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia". This phase II trial studies the side effects and how well giving combination chemotherapy together with dasatinib works in treating patients with newly diagnosed acute myeloid leukemia. Drugs used in chemotherapy, such as daunorubicin hydrochloride and cytarabine, work in different ways to stop the ...

What is the current status of trial NCT01238211?

This trial is currently completed. It is a Phase 2 study. The enrollment target is 61 participants. The study started on 2010-12-14. Estimated completion is 2021-03-15.

What conditions does trial NCT01238211 study?

This clinical trial studies the following conditions: Acute Myeloid Leukemia, Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome, Secondary Acute Myeloid Leukemia, Therapy-Related Acute Myeloid Leukemia, Adult Acute Myeloid Leukemia With Inv(16)(p13.1q22); CBFB-MYH11. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT01238211?

The interventions under investigation include: Laboratory Biomarker Analysis (OTHER), Cytarabine (DRUG), Dasatinib (DRUG), Daunorubicin Hydrochloride (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT01238211?

This trial is sponsored by National Cancer Institute (NCI), which has 2,390 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT01238211 being conducted?

This trial has 20 study locations across Delaware, Florida, Illinois. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial