Yale University

Open enrollment with an early-phase pipeline tilt

According to ClinicalTrials.gov-derived indexes, Yale University sits in the top decile of US sponsors by registered trial count (#13 of 15,742 sponsors by registered trial count).

1,492 total trials 254 currently recruiting 1005 completed early-phase tilt top decile by trial count

Yale University: 1,492 sponsored US clinical trials, 254 recruiting.

Yale University sponsors 1,492 registered US clinical trials on ClinicalTrials.gov, 254 of them currently recruiting, and 1,005 completed. 99 of these trials are in Phase 3-4 (later-stage) and 579 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Opioid Use Disorder, with 19 trials.

Top-decile sponsor footprint

Yale University ranks in the top decile of sponsors by registered trial count (#13 of 15,742 sponsors by registered trial count). Volume at this scale usually reflects a long institutional pipeline, read phase tilt and therapeutic areas below before treating it as current-year activity.

Trial completion reliability score

D 60/100

1,005 of 1,138 decided trials (Completed vs. Terminated on ClinicalTrials.gov) reached their planned completion (88.3%), vs. national p10 68.4% / p90 100% among 1,234 sponsors with at least 10 decided trials. Still-open trials (Recruiting, Active-not-recruiting, Not-yet-recruiting) are excluded since they have not reached an outcome yet.

Open and recent trials

1,492 total, page 15 of 30

COMPLETED Phase 2

Efficacy and Mechanisms of Naltrexone+Bupropion for Binge Eating Disorder

NCT03539900

COMPLETED Early Phase 1

Peripheral Benzodiazepine Receptors (PBR28) Brain PET Imaging With Lipopolysaccharide Challenge for the Study of Microglia Function in Alzheimer's Disease

NCT04057807

COMPLETED NA

Optimizing Electronic Alerts for Acute Kidney Injury

NCT02753751

COMPLETED NA

Home vs. Office Foley Catheter Removal in Women With Voiding Difficulty Following Pelvic Reconstructive Surgery

NCT03373773

COMPLETED NA

Effect of Physician Race and Gender on Simulated Patients' Ratings

NCT04190901

COMPLETED Phase 1

Investigation of Cocaine Addiction Using mGluR5 PET and fMRI

NCT03471182

COMPLETED NA

Electronic Cigarette Use in Young Adult Men and Women

NCT03089541

TERMINATED Phase 2

Ketamine in Borderline Personality Disorder

NCT03395314

COMPLETED Phase 1

Mavoglurant in Alcohol Drinking

NCT03327792

TERMINATED Early Phase 1

A Pilot Study Using Short-Term Cultured Anti-Tumor Autologous Lymphocytes

NCT03526185

COMPLETED NA

Comparison of Intravascular Uptake and Pain Perception During Epidural Injection Using 22 Gauge vs 25 Gauge Needle

NCT04350307

TERMINATED

Hand Grip Strength as a Marker of Frailty in Surgical Patients

NCT02966470

COMPLETED

Post-Market Surveillance With a Novel mHealth Platform

NCT03436082

COMPLETED NA

Targeting Self-regulatory Deficits Through Cognitive Remediation Intervention

NCT03373240

COMPLETED Early Phase 1

Investigating the Role of the Polyol Pathway in the Central Nervous System Production of Fructose

NCT03469492

COMPLETED NA

Does Mindfulness Enhance BMI in Obese Adolescents Enrolled in the Bright Bodies Weight Management Program?

NCT03611660

COMPLETED Phase 1

Project EMPOWERING: Evidence-based PrEP for Justice-Involved Women and Their Risk Networks

NCT03293290

COMPLETED Early Phase 1

Examine the Feasibility of a Standardized Field Test for Marijuana Impairment: Laboratory Evaluations

NCT03191084

TERMINATED Early Phase 1

Mechanisms of Hypertension in Women With Polycystic Ovary Syndrome

NCT04327934

COMPLETED Early Phase 1

Development of Agents to Diminish the Risk of Hypoglycemia-induced Brain Injury in Type 1 Diabetes

NCT03356457

COMPLETED Early Phase 1

Imaging the Neurochemistry of Drug Addiction With PET

NCT02817698

TERMINATED Early Phase 1

Glucocorticoid Antagonist Treatment for Tobacco Use Disorder

NCT03248713

TERMINATED NA

Pregnancy, Mindfulness, and Massage

NCT03276208

COMPLETED Phase 1

Improving Post-Prandial Blood Glucose Control With Afrezza During Closed-Loop Therapy

NCT03234491

COMPLETED NA

Brief Interventions With Text Messaging to Reduce Adolescent Alcohol and Marijuana Use

NCT03401333

COMPLETED Phase 1

Psilocybin for the Treatment of Migraine Headache

NCT03341689

TERMINATED NA

Using an Artificial Pancreas System in Older Adult Type 1 Diabetes Mellitus Patients

NCT03353792

COMPLETED

The Safety of Thoracentesis, Tunneled Pleural Catheter, and Chest Tubes in Patients Taking Novel Oral Anti-Coagulants

NCT03535883

COMPLETED NA

Development and Preliminary Trial of a Brief, Portable Health Intervention for Rural Sexual Minority Emerging Adults

NCT03751020

COMPLETED NA

Development of a Videogame Prototype Targeting Cigarette and Marijuana Smoking, and Tobacco Product Prevention Among Young Adolescents (smokeScreen)

NCT03722888

COMPLETED NA

Brain Emotion Circuitry-Targeted Self-Monitoring and Regulation Therapy (BE-SMART)

NCT03183388

COMPLETED Early Phase 1

Reducing the Risk of Metabolic Decompensation in Diabetic Adolescents by Supervised School Administration of Insulin

NCT03400501

TERMINATED Phase 4

Safety and Efficacy of Oral TXA in Reducing Blood Loss and Transfusion in Hip Fractures

NCT02908516

COMPLETED

Development of Reward Processing in Prenatally Exposed Adolescents and Young Adults

NCT03268759

COMPLETED Phase 2

Behavioral and Pharmacologic Treatment of Binge Eating and Obesity: Specialist Treatment

NCT03063606

COMPLETED Phase 1

Patient Driven Recovery With Nalmefene and Coaching

NCT03279562

COMPLETED Phase 2

Behavioral and Pharmacologic Treatment of Binge Eating and Obesity: Maintenance Therapy

NCT03047005

TERMINATED NA

Mindfulness Interventions and Cutaneous T Cell Lymphoma (CTCL)

NCT03174808

COMPLETED Phase 1

Vitamin D as a Therapeutic Adjunct in the Stimulant Treatment of ADHD

NCT03103750

COMPLETED Phase 2

Toradol to Reduce Ureteroscopic Symptoms Trial

NCT03111381

TERMINATED Phase 1

Cognitive and Psychophysiological Effects of Delta-9-Tetrahydrocannabinol in Bipolar Disorder

NCT03206463

COMPLETED Phase 2

Ipilimumab and Nivolumab in Patients With Anti-PD-1-axis Therapy-resistant Advanced Non-small Cell Lung Cancer.

NCT03262779

COMPLETED NA

STAMP: Sharing and Talking About My Preferences

NCT03137459

COMPLETED Phase 1

A Sunscreen Based on Bioadhesive Nanoparticles

NCT02668536

COMPLETED NA

Mindfulness Based Stress Reduction for Metabolic Syndrome

NCT03296514

COMPLETED Phase 1

Empagliflozin in Heart Failure: Diuretic and Cardio-Renal Effects

NCT03027960

TERMINATED Phase 2

Neoadjuvant Modified FOLFIRINOX and Stereotactic Body Radiation Therapy in Borderline Resectable Pancreatic Adenocarcinoma

NCT03099265

TERMINATED Phase 2

A Trial of Systemic Chemotherapy in Combination With Conventional Transarterial Chemoembolization in Patients With Advanced Intra-Hepatic Cholangiocarcinoma

NCT02994251

COMPLETED NA

Project SMART Automated Pillbox Study

NCT04418076

TERMINATED Phase 2

Naltrexone-Bupropion Versus Placebo-Bupropion for Weight Loss in Schizophrenia

NCT03132571

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Phase Distribution

PhaseTrial count
Phase 1 312
Phase 2 267
Phase 3 52
Phase 4 47

What is open in the Yale University pipeline

254 recruiting of 1,492 indexed (17% open); 1,005 completed (67%).

Phase mix: 99 late (III/IV) vs 579 early (I/II) (early-phase heavy).

Top condition: Opioid Use Disorder (19 trials), 9 others listed.

How open-pipeline share is computed

Recruiting share is recruiting_count divided by trial_count for this sponsor in the public registry export. Status can change between pulls; treat the figure as a research-attention snapshot, not product availability.

Yale University: open-pipeline peers nationwide

Peers matched on 1,492 registered trials and 17% open enrollment, not the therapeutic-area sidebar.

Yale University sits at or above the median trial volume and at or above the median recruiting share among these 9 nationwide peers -- the two do not always move together. Source: ClinicalTrials.gov (2026-08-08 snapshot). 2×2 strategic matrix plotting 9 entities by Total trials (X) and Recruiting share (Y), with a crosshair dividing the plot into four quadrants. Higher volume & more openFocused & more openHigher volume, mostly closedSmaller & mostly closed 05001,0001,5002,000 5%10%15%20% Total trials Recruiting share Yale UniversityWashington University School of MedicineJohns Hopkins UniversityUniversity of PennsylvaniaNovartis PharmaceuticalsNYU Langone HealthCSL BehringPenn State UniversityUniversity of Hawaii
Yale University sits at or above the median trial volume and at or above the median recruiting share among these 9 nationwide peers -- the two do not always move together. Source: ClinicalTrials.gov (2026-08-08 snapshot).

Yale University sits at or above the median trial volume and at or above the median recruiting share among these 9 nationwide peers -- the two do not always move together.

Sponsors near 1,492 trials (± recruiting share)

Sponsors near 17% open enrollment (± trial volume)

What to do with this Yale University page

1,492 registered trials is a research-attention snapshot, not an endorsement of Yale University or any single study.

  • 254 of Yale University's trials are currently recruiting, check each one's own eligibility criteria before contacting a site. Browse recruiting trials
  • Opioid Use Disorder is the condition Yale University studies most, compare against other sponsors active in the same condition before evaluating a specific study. See Opioid Use Disorder trials
  • Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide

Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. Yale University pipeline card: 1,492 registered trials from official public datasets. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.