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NCT03469492 · ClinicalTrials.gov registry record · Early Phase 1
Investigating the Role of the Polyol Pathway in the Central Nervous System Production of Fructose
A Early Phase 1 study of Hyperglycaemia (Diabetic), sponsored by Yale University.
- Completed
- Registry status
- Early Phase 1
- Development phase
- 8
- Enrollment target
- 1
- Study location
NCT03469492: Completed Early Phase 1 study of Hyperglycaemia (Diabetic), sponsored by Yale University.
NCT03469492 is a Early Phase 1 study of Hyperglycaemia (Diabetic) that has completed, run by Yale University. The registered enrollment target is 8 participants, below the 53-participant average among 2,764 other Early Phase 1 trials with a reported enrollment target (85% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03469492, a Early Phase 1 study of Hyperglycaemia (Diabetic), has completed, sponsored by Yale University.
- COMPLETED
- Registry status
- Early Phase 1
- Development phase
- 8 participants
- Enrollment target
- 1
- Study location
Study Summary
To investigate whether longer-term improvement of glycemic control in poorly controlled diabetes patients with a 12-week intensified insulin treatment regimen will lead to decreased polyol pathway activity.
Primary Outcome
HbA1c levels measured by MRS scanning during a hyperglycaemic clamp. Result reported is the mean decrease in HbA1C. A decrease in HbA1c indicates improvement in brain glucose levels.
Conditions Studied
Interventions
- DRUG Insulin
- BEHAVIORAL exercise
- DIETARY_SUPPLEMENT Dietary counseling
Study Locations (1)
Connecticut
- The Anylan Center - New Haven
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 8 participants |
| Start Date | 2018-01-18 |
| Est. Completion | 2020-03-20 |
| Phase | Early Phase 1 |
What the finished NCT03469492 record still lists
NCT03469492 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 8 participants, a relatively small participant target, below the 53-participant average among 2,764 other Early Phase 1 trials with a reported enrollment target (85% lower).
The record links to 1 condition, with Hyperglycaemia (Diabetic) appearing as the primary indexed condition, and to 3 interventions - of which Insulin is the first listed.
NCT03469492 reports a single indexed study location in Connecticut.
Frequently Asked Questions
What is clinical trial NCT03469492 about?
NCT03469492 is a clinical study titled "Investigating the Role of the Polyol Pathway in the Central Nervous System Production of Fructose". To investigate whether longer-term improvement of glycemic control in poorly controlled diabetes patients with a 12-week intensified insulin treatment regimen will lead to decreased polyol pathway activity.
What is the current status of trial NCT03469492?
This trial is currently completed. It is a Early Phase 1 study. The enrollment target is 8 participants. The study started on 2018-01-18. Estimated completion is 2020-03-20.
What conditions does trial NCT03469492 study?
This clinical trial studies the following conditions: Hyperglycaemia (Diabetic).
What interventions are being tested in trial NCT03469492?
The interventions under investigation include: Insulin (DRUG), exercise (BEHAVIORAL), Dietary counseling (DIETARY_SUPPLEMENT).
Who is sponsoring clinical trial NCT03469492?
This trial is sponsored by Yale University, which has 1,492 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT03469492 being conducted?
This trial has 1 study location across Connecticut. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Hyperglycaemia (Diabetic)
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT03469492's enrollment target sits among peer trials
8 1783rd of 2000 higher than 176 of 2,000 other Early Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Early Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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