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NCT03471182 · ClinicalTrials.gov registry record · Phase 1
Investigation of Cocaine Addiction Using mGluR5 PET and fMRI
A Phase 1 study, sponsored by Yale University.
- Completed
- Registry status
- Phase 1
- Development phase
- 32
- Enrollment target
NCT03471182: Completed Phase 1 study, sponsored by Yale University.
NCT03471182 is a Phase 1 study that has completed, run by Yale University. The registered enrollment target is 32 participants, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (47% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03471182, a Phase 1 study, has completed, sponsored by Yale University.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 32 participants
- Enrollment target
Study Summary
The proposed research program will investigate the changes in brain chemistry and circuitry that 're-wire' the brain during chronic cocaine use, promote relapse, and complicate treatment efforts. Currently-using and non-treatment-seeking individuals with a cocaine use disorder will undergo a cocaine self-administration paradigm 2-5 days prior to completing positron emission tomography (PET) and functional magnetic resonance imaging (fMRI).
Primary Outcome
Receptor availability assessed as the volume of distribution (VT) of \[18F\]FPEB radiotracer, measured using positron emission tomography (PET). Higher \[18F\]FPEB VT values indicate a greater availability of mGluR5 receptors.
Interventions
- RADIATION Positron Emission Tomography
- OTHER Magnetic Resonance Imaging
- BEHAVIORAL Psychiatric and Cognitive Testing
- DRUG Cocaine Self-adminstration
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 32 participants |
| Start Date | 2018-02-26 |
| Est. Completion | 2022-08-18 |
| Phase | Phase 1 |
What the finished NCT03471182 record still lists
NCT03471182 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 32 participants, a relatively small participant target, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (47% lower).
The record links to 0 conditions, and to 4 interventions - of which Positron Emission Tomography is the first listed.
NCT03471182 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT03471182 about?
NCT03471182 is a clinical study titled "Investigation of Cocaine Addiction Using mGluR5 PET and fMRI". The proposed research program will investigate the changes in brain chemistry and circuitry that 're-wire' the brain during chronic cocaine use, promote relapse, and complicate treatment efforts. Currently-using and non-treatment-seeking individuals with a cocaine use disorder will undergo a cocaine...
What is the current status of trial NCT03471182?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 32 participants. The study started on 2018-02-26. Estimated completion is 2022-08-18.
What interventions are being tested in trial NCT03471182?
The interventions under investigation include: Positron Emission Tomography (RADIATION), Magnetic Resonance Imaging (OTHER), Psychiatric and Cognitive Testing (BEHAVIORAL), Cocaine Self-adminstration (DRUG).
Who is sponsoring clinical trial NCT03471182?
This trial is sponsored by Yale University, which has 1,492 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT03471182's enrollment target sits among peer trials
32 1296th of 2000 higher than 679 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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