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ClinicalTrials.gov 32 recruiting now official registry

High Grade Glioma clinical trials

32 of 43 indexed High Grade Glioma trials are currently recruiting.

43 US clinical trials · 32 currently recruiting

High Grade Glioma is the subject of 43 registered US clinical trials on ClinicalTrials.gov, 32 of them currently open to new participants. 1 are in Phase 3-4 (later-stage) and 37 in Phase 1-2 (earlier-stage). The most active sponsor is Nationwide Children's Hospital, running 8 of these trials.

The research picture

High Grade Glioma has 43 registered US clinical trials, 32 of them open to new participants right now, about 74% of the total.

32
recruiting participants now
74%
of trials open to enrollment
1
in Phase 3–4 (later-stage)
8
top sponsor: Nationwide Children's Hospital
Phase 130Phase 27Phase 41

Active & Recent Trials

43 total, page 1 of 1

RECRUITING 784 participants

The SUPRAMAX Study: Supramaximal Resection Versus Maximal Resection for High-Grade Glioma Patients (ENCRAM 2201)

Jasper Gerritsen

NCT06118723

RECRUITING 350 participants

Targeted Pediatric High-Grade Glioma Therapy

Nationwide Children's Hospital

NCT05839379

RECRUITING Phase 2 120 participants

PEP-CMV Vaccine Targeting CMV Antigen to Treat Newly Diagnosed Pediatric HGG and DIPG and Recurrent Medulloblastoma

Nationwide Children's Hospital

NCT05096481

RECRUITING Phase 2 120 participants

Study of Ribociclib and Everolimus in HGG and DIPG or Ribociclib and Temozolomide in DHG, H3G34-mutant

Nationwide Children's Hospital

NCT05843253

RECRUITING Phase 4 100 participants

Dabrafenib and/or Trametinib Rollover Study

Novartis Pharmaceuticals

NCT03340506

RECRUITING Early Phase 1 82 participants

A Phase 0/1 Study of BDTX-1535 in Recurrent High-Grade Glioma (rHGG) and Newly Diagnosed Glioblastoma (nGBM) Participants With EGFR Alterations or Fusions

St. Joseph's Hospital and Medical Center, Phoenix

NCT06072586

RECRUITING Phase 1 70 participants

DB107-RRV, DB107-FC, and Radiation Therapy With or Without Temozolomide (TMZ) for High Grade Glioma

University of California, San Francisco

NCT06504381

RECRUITING Phase 1 65 participants

Lutathera for Treatment of Recurrent or Progressive High-Grade CNS Tumors

Nationwide Children's Hospital

NCT05278208

RECRUITING Phase 2 60 participants

Study of Olutasidenib and Temozolomide in HGG

Rigel Pharmaceuticals

NCT06161974

RECRUITING Phase 2 52 participants

Entrectinib as a Single Agent in Upfront Therapy for Children <3 Years of Age With NTRK1/2/3 or ROS1-FUSED CNS Tumors

St. Jude Children's Research Hospital

NCT06528691

RECRUITING Phase 1 52 participants

Safety and Efficacy Study of TX103 CAR-T Cell Therapy for Recurrent or Progressive Grade 4 Glioma.

Tcelltech

NCT06482905

RECRUITING Phase 1 50 participants

Trametinib and Everolimus for Treatment of Pediatric and Young Adult Patients With Recurrent Gliomas (PNOC021)

University of California, San Francisco

NCT04485559

RECRUITING Phase 1 48 participants

Loc3CAR: Locoregional Delivery of B7-H3-CAR T Cells for Pediatric Patients With Primary CNS Tumors

St. Jude Children's Research Hospital

NCT05835687

RECRUITING Early Phase 1 39 participants

Concurrent XRD-0394 With Radiation Therapy for High Grade Gliomas

NYU Langone Health

NCT06829173

RECRUITING Phase 1 37 participants

C7R-GD2.CAR T Cells for Patients With GD2-expressing Brain Tumors (GAIL-B)

Baylor College of Medicine

NCT04099797

RECRUITING Phase 2 33 participants

DB107-Retroviral Replicating Vector (RRV) Combined With DB107-Flucytosine (FC) in Patients With Recurrent Glioblastoma or Anaplastic Astrocytoma

Ashish Shah

NCT06264388

RECRUITING NA 32 participants

Surgical Tissue Flap to Bypass the Blood Brain Barrier in Glioblastoma

Northwell Health

NCT05954858

RECRUITING Phase 1 32 participants

Concurrent Azeliragon With Craniospinal Irradiation

NYU Langone Health

NCT06724926

RECRUITING Early Phase 1 30 participants

Study of Sonodynamic Therapy in Participants with Recurrent High-Grade Glioma

Nader Sanai

NCT04559685

RECRUITING Early Phase 1 30 participants

18F-Fluciclovine PET-MRI in High-grade Glioma

Children's Hospital of Philadelphia

NCT05553041

RECRUITING Phase 1 28 participants

Study of LAM561 Acid in Pediatric Patients With Malignant Glioma and Other Advanced Solid Tumors

Laminar Pharmaceuticals

NCT04299191

RECRUITING Phase 1 27 participants

MAPK Inhibition Combined With Anti-PD1 Therapy for BRAF-altered Pediatric Gliomas

Ann & Robert H Lurie Children's Hospital of Chicago

NCT06712875

RECRUITING Phase 1 24 participants

STARLITE for Unresectable High-Grade Gliomas

University of Miami

NCT06428045

RECRUITING Early Phase 1 20 participants

Multiparametic Metabolic and Hypoxic PET/MRI for Disease Assessment in High Grade Glioma

University of Alabama at Birmingham

NCT05632562

RECRUITING Phase 1 18 participants

Phase 1 Study of Locoregional Injections of Ex Vivo Expanded Natural Killer Cells

Nationwide Children's Hospital

NCT04254419

RECRUITING Phase 1 18 participants

Atovaquone Combined With Radiation in Children With Malignant Brain Tumors

Emory University

NCT06624371

RECRUITING NA 16 participants

MRI in High-Grade Glioma Patients Undergoing Chemoradiation

Wake Forest University Health Sciences

NCT05212272

RECRUITING Early Phase 1 15 participants

Lorlatinib for Newly-Diagnosed High-Grade Glioma With ROS or ALK Fusion

Nationwide Children's Hospital

NCT06333899

RECRUITING Early Phase 1 15 participants

A Pilot Study of Larotrectinib for Newly-Diagnosed High-Grade Glioma With NTRK Fusion

Nationwide Children's Hospital

NCT04655404

RECRUITING Early Phase 1 12 participants

Superselective Intra-arterial Cerebral Infusion of Temsirolimus in HGG

Nader Sanai

NCT05773326

RECRUITING NA 10 participants

Omental Tissue Autograft in Human Recurrent Glioblastoma Multiforme (rGBM)

Northwell Health

NCT05979064

RECRUITING Phase 1 10 participants

Prospective Surgical Study on the Pattern of Electrical Activity in High Grade Glioma as a Predictor of Progression

Case Comprehensive Cancer Center

NCT05565118

ACTIVE NOT RECRUITING Phase 1 64 participants

A Phase 1b Study of PTC596 in Children With Newly Diagnosed Diffuse Intrinsic Pontine Glioma and High Grade Glioma

Nationwide Children's Hospital

NCT03605550

ACTIVE NOT RECRUITING Phase 2 62 participants

Nivolumab in Patients With IDH-Mutant Gliomas With and Without Hypermutator Phenotype

National Cancer Institute (NCI)

NCT03718767

ACTIVE NOT RECRUITING Phase 1 50 participants

Novel Targeted Radiotherapy in Pediatric Patients With Inoperable Relapsed or Refractory HGG

Cellectar Biosciences

NCT05610891

ACTIVE NOT RECRUITING Early Phase 1 39 participants

Study of DSP-0390 in Patients With Recurrent High-Grade Glioma

Sumitomo Pharma America

NCT05023551

ACTIVE NOT RECRUITING Phase 1 28 participants

A Study of RNA-lipid Particle (RNA-LP) Vaccines for Newly Diagnosed Pediatric High-Grade Gliomas (pHGG) and Adult Glioblastoma (GBM)

University of Florida

NCT04573140

ACTIVE NOT RECRUITING Phase 1 18 participants

IL-8 Receptor-modified CD70 CAR T Cell Therapy in CD70+ Pediatric High-grade Glioma (HGG)

University of Florida

NCT06946680

ACTIVE NOT RECRUITING Phase 1 16 participants

Study of Safety and Pharmacokinetic Properties of Oral OKN-007 in Patients with Recurrent High-Grade Glioma

Oblato

NCT05561374

ACTIVE NOT RECRUITING Early Phase 1 11 participants

A Study of 68Ga-PSMA-11 PET Scans in People With Brain Tumors

Memorial Sloan Kettering Cancer Center

NCT06209567

COMPLETED Phase 2 31 participants

Low Dose Radiation Therapy for Glioblastoma Multiforme

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

NCT01466686

COMPLETED Phase 1 22 participants

Study to Evaluate 5-ALA Combined With CV01 Delivery of Ultrasound in Recurrent High Grade Glioma

Alpheus Medical

NCT05362409

COMPLETED Phase 1 19 participants

A Study of Ribociclib and Everolimus Following Radiation Therapy in Children With Newly Diagnosed Non-biopsied Diffuse Pontine Gliomas (DIPG) and RB+ Biopsied DIPG and High Grade Gliomas (HGG)

Children's Hospital Medical Center, Cincinnati

NCT03355794

Phase Distribution

PhaseTrial count
Phase 1 30
Phase 2 7
Phase 4 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the High Grade Glioma Trial Landscape

43 indexed High Grade Glioma studies · 32 recruiting (74%).

Phase mix: 1 late (III/IV) vs 37 early (I/II).

Top sponsor: Nationwide Children's Hospital (8 trials), 9 others listed. 43 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for High Grade Glioma?

PlainTrial tracks 43 US clinical trials for High Grade Glioma, of which 32 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for High Grade Glioma?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.