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NCT06264700 · ClinicalTrials.gov registry record · NA
Applying Directly Observed Therapy to Hydroxyurea to Realize Effectiveness
A NA study of Sickle Cell Disease, sponsored by Nationwide Children's Hospital.
- Recruiting
- Registry status
- NA
- Development phase
- 60
- Enrollment target
- 3
- Study locations
NCT06264700: Recruiting NA study of Sickle Cell Disease, sponsored by Nationwide Children's Hospital.
NCT06264700 is a NA study of Sickle Cell Disease that is actively recruiting participants, run by Nationwide Children's Hospital. The registered enrollment target is 60 participants, below the 293-participant average among 213 other Sickle Cell Disease trials with a reported enrollment target (80% lower). The trial reports 3 study locations across 3 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06264700, a NA study of Sickle Cell Disease, is actively recruiting participants, sponsored by Nationwide Children's Hospital.
- RECRUITING
- Registry status
- NA
- Development phase
- 60 participants
- Enrollment target
- 3
- Study locations
Study Summary
This study is for caregivers of young children with sickle cell disease and adolescents with sickle cell disease who are currently prescribed hydroxyurea and are receiving care at one of the study sites. The study will assess retention and engagement during a pilot randomized control trial comparing video directly observed therapy (VDOT) to attention control. We also hope to understand more about patient and family preferences longer-term adherence monitoring and intervention. Participants will use an electronic adherence monitor (provided by the study team) to measure how often they are taking their hydroxyurea. Participants will also be asked to complete questionnaires throughout the study period to provide information about their expectations for, experience with, and satisfaction with the study materials.
Primary Outcome
The number of participants who are retained on both study arms during each study period will be reported.
Conditions Studied
Interventions
- BEHAVIORAL Video Directly Observed Therapy (VDOT)
- BEHAVIORAL Health Reminder Tip Alerts
Study Locations (3)
Illinois
- Lurie Children's Hospital - Chicago
Ohio
- Nationwide Children's Hospital - Columbus
Rhode Island
- Hasbro Children's Hospital - Providence
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 60 participants |
| Start Date | 2024-07-11 |
| Est. Completion | 2025-12 |
| Phase | NA |
What NCT06264700 shows while recruiting
NCT06264700 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 60 participants, a relatively small participant target, below the 293-participant average among 213 other Sickle Cell Disease trials with a reported enrollment target (80% lower).
The record links to 1 condition, with Sickle Cell Disease appearing as the primary indexed condition, and to 2 interventions - of which Video Directly Observed Therapy (VDOT) is the first listed.
NCT06264700 reports a single indexed study location in Illinois, Ohio, Rhode Island.
Frequently Asked Questions
What is clinical trial NCT06264700 about?
NCT06264700 is a clinical study titled "Applying Directly Observed Therapy to Hydroxyurea to Realize Effectiveness". This study is for caregivers of young children with sickle cell disease and adolescents with sickle cell disease who are currently prescribed hydroxyurea and are receiving care at one of the study sites. The study will assess retention and engagement during a pilot randomized control trial comparing...
What is the current status of trial NCT06264700?
This trial is currently recruiting. It is a NA study. The enrollment target is 60 participants. The study started on 2024-07-11. Estimated completion is 2025-12.
What conditions does trial NCT06264700 study?
This clinical trial studies the following conditions: Sickle Cell Disease.
What interventions are being tested in trial NCT06264700?
The interventions under investigation include: Video Directly Observed Therapy (VDOT) (BEHAVIORAL), Health Reminder Tip Alerts (BEHAVIORAL).
Who is sponsoring clinical trial NCT06264700?
This trial is sponsored by Nationwide Children's Hospital, which has 188 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06264700 being conducted?
This trial has 3 study locations across Illinois, Ohio, Rhode Island. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Sickle Cell Disease
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Where NCT06264700's enrollment target sits among peer trials
60 93rd of 213 higher than 118 of 213 other Sickle Cell Disease trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Sickle Cell Disease trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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