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NCT03510442 · ClinicalTrials.gov registry record
Natural History, Genetics, and Pathophysiology of Systemic Juvenile Idiopathic Arthritis, Adult-Onset Still's Disease, and Related Conditions
A clinical trial of Arthritis and Systemic Inflammation, sponsored by National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS).
- Recruiting
- Registry status
- 2,000
- Enrollment target
- 1
- Study location
NCT03510442: Recruiting study of Arthritis and Systemic Inflammation, sponsored by National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS).
NCT03510442 is a study of Arthritis and Systemic Inflammation that is actively recruiting participants, run by National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS). The registered enrollment target is 2,000 participants, below the 4,468-participant average among 48 other Arthritis trials with a reported enrollment target (55% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03510442, a study of Arthritis and Systemic Inflammation, is actively recruiting participants, sponsored by National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS).
- RECRUITING
- Registry status
- 2,000 participants
- Enrollment target
- 1
- Study location
Study Summary
Background: Inflammatory conditions can cause symptoms like fevers, arthritis, and rash. Systemic juvenile idiopathic arthritis (sJIA) is one of these conditions. So is adult-onset Still s disease (AOSD). Their causes are unknown. Researchers want to learn more about these conditions. This includes genetic changes and environmental factors. Objective: To study sJIA and AOSD in children and adults over time. Eligibility: People with known or suspected sJIA, AOSD, or similar inflammatory condition Design: Participants will be screened with a phone call. Participants will have 1 visit. It may be outpatient or they may be admitted to the clinic. The visit may last up to 5 days. Participants will have: * Medical history * Physical exam * Musculoskeletal exam * Questions about overall health and quality of life, disease activity, functional status, and cognitive ability. Participants may also have: * Pictures taken of their skin, joints, or spine * Blood, urine, and stool tests * Scans or X-rays of joints with arthritis * Chest X-ray * Heart tests * Skin biopsy. The skin will be numbed. The top layers of a small area will be scraped off. Participants who have a joint aspiration may provide a fluid sample. The joint will be prepared, then fluid is removed by needle. A corticosteroid may be injected. Participants who have a bone marrow biopsy may provide sample cells. Participants may be seen by NIH specialists. Members of the participant s family and healthy volunteers may give blood or saliva samples for genetic testing. Participants may repeat some study tests every 6 months.
Primary Outcome
sequencing aims to identify variants to help stratify sJIA, Still's and inflammatory disease patients
Conditions Studied
Study Locations (1)
Maryland
- National Institutes of Health Clinical Center - Bethesda
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 2,000 participants |
| Start Date | 2018-05-21 |
| Est. Completion | 2050-01-01 |
Sponsor
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)93 total trials
What NCT03510442 shows while recruiting
NCT03510442 is an observational study that tracks outcomes without assigning an intervention. Its 2,000 participants enrollment target places it among the larger protocols in the corpus, below the 4,468-participant average among 48 other Arthritis trials with a reported enrollment target (55% lower).
The record links to 4 conditions, with Arthritis appearing as the primary indexed condition, and to 0 interventions.
NCT03510442 reports a single indexed study location in Maryland.
Frequently Asked Questions
What is clinical trial NCT03510442 about?
NCT03510442 is a clinical study titled "Natural History, Genetics, and Pathophysiology of Systemic Juvenile Idiopathic Arthritis, Adult-Onset Still's Disease, and Related Conditions". Background: Inflammatory conditions can cause symptoms like fevers, arthritis, and rash. Systemic juvenile idiopathic arthritis (sJIA) is one of these conditions. So is adult-onset Still s disease (AOSD). Their causes are unknown. Researchers want to learn more about these conditions. This includes...
What is the current status of trial NCT03510442?
This trial is currently recruiting. The enrollment target is 2,000 participants. The study started on 2018-05-21. Estimated completion is 2050-01-01.
What conditions does trial NCT03510442 study?
This clinical trial studies the following conditions: Arthritis, Systemic Inflammation, Still's Disease, Adult-Onset, Autoinflammatory Syndrome.
Who is sponsoring clinical trial NCT03510442?
This trial is sponsored by National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), which has 93 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT03510442 being conducted?
This trial has 1 study location across Maryland. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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Where NCT03510442's enrollment target sits among peer trials
2,000 5th of 48 higher than 43 of 48 other Arthritis trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Arthritis trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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