National Institute of Allergy and Infectious Diseases (NIAID)

2,006 total trials 155 currently recruiting 1642 completed

National Institute of Allergy and Infectious Diseases (NIAID) sponsors 2,006 registered US clinical trials on ClinicalTrials.gov, 155 of them currently recruiting, and 1,642 completed. 177 of these trials are in Phase 3-4 (later-stage) and 1,291 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is HIV Infections, with 195 trials.

Trial Pipeline

2,006 total, page 2 of 41

RECRUITING Phase 2

Expanding Liver Transplant Immunosuppression Minimization Via Everolimus

NCT06280950

RECRUITING Phase 2

A Clinical Trial of Combination HIV-Specific Broadly Neutralizing Monoclonal Antibodies Combined With ART Initiation During Acute HIV Infection to Induce HIV Remission

NCT05719441

RECRUITING Phase 1

Study of the Infectivity, Safety and Immunogenicity of Two Recombinant, Live-Attenuated, B/HPIV3 Vectored Vaccines Expressing the Fusion Glycoprotein of HMPV Delivered by Nasal Spray to HPIV3-Seropositive Children 24 to <60 Months of Age

NCT06546423

RECRUITING

Hemophagocytic Lymphohistiocytosis (HLH) Evaluation and Research of Clinical, ImmUnoLogic and TranscriptomE Study

NCT06339177

RECRUITING Phase 2

Advancing Transplantation Outcomes in Children

NCT06055608

RECRUITING Phase 1

CAR-T Cell Therapy for Desensitization in Kidney Transplantation

NCT06056102

RECRUITING

Protocol CAUSE-03 / CHEETAH

NCT06136091

RECRUITING Phase 1

Base Editing for Mutation Repair in Hematopoietic Stem & Progenitor Cells for X-Linked Chronic Granulomatous Disease

NCT06325709

RECRUITING Phase 1

Evaluation of Safety, Immunogenicity and Efficacy of a Triple Immune Regimen in Adults Initiated on ART During Acute HIV-1

NCT06071767

RECRUITING Phase 2

Cytomegalovirus (CMV) Vaccine in Orthotopic Liver Transplant Candidates

NCT06075745

RECRUITING Phase 2

Tocilizumab in Lung Transplantation

NCT06033196

RECRUITING Phase 1

Study of Oral and Long-Acting Injectable Cabotegravir and Rilpivirine in Virologically Suppressed Children Living With HIV-1, Two to Less Than 12 Years of Age

NCT05660980

RECRUITING

Detection and Characterization of Neurologic Manifestations of Inborn and Acquired Errors of Immunity

NCT06169150

RECRUITING Phase 2

Assessment of Biomarker-Guided CNI Substitution In Kidney Transplantation

NCT05917522

RECRUITING

Establishment of Biobank of Nasal Epithelium Samples From Healthy Volunteers

NCT06120244

RECRUITING

Observational Digital Biomarker Discovery in Respiratory Virus Challenge Studies

NCT04772170

RECRUITING Phase 1

Daratumumab in Primary Antiphospholipid Syndrome

NCT05671757

RECRUITING

Evaluating the Genetics and Immunology of Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Cervical Adenitis (PFAPA) Syndrome and Other Tonsil Disorders

NCT05656365

RECRUITING Phase 1

Safety and Immunogenicity of Recombinant Varicella Zoster Virus Vaccine in People With HIV Who Have a CD4 Count Less Than 300 or Greater Than or Equal to 300 and a Healthy Control Population

NCT05580458

RECRUITING

A Repository to Study Host-Microbiome Interactions in Health and Disease

NCT05656378

RECRUITING Phase 2

Evaluate the Efficacy and Safety of Ruxolitinib on Hair Regrowth in Patients With Autoimmune Polyendocrinopathy Candidiasis Ectodermal Dystrophy (APECED)-Associated Alopecia Areata

NCT05398809

RECRUITING Phase 4

Ocrelizumab Discontinuation in Relapsing Multiple Sclerosis

NCT05285891

RECRUITING

Respiratory Virus Sampling and Repository

NCT05266222

RECRUITING Phase 1

Fecal Microbiota Transplantation for Chronic Granulomatous Disease-Associated Colitis

NCT05333471

RECRUITING Phase 1

NADPH Oxidase Correction in mRNA-transfected Granulocyte-enriched Cells in Chronic Granulomatous Disease (CGD)

NCT05189925

RECRUITING Phase 1

Allogeneic Hematopoietic Stem Cell Transplantation for Chronic Granulomatous Disease (CGD) With an Alemtuzumab, Busulfan and TBI-based Conditioning Regimen Combined With Cytokine (IL-6, +/- IFN-gamma) Antagonists

NCT05463133

RECRUITING Phase 2

VIBRANT: VIB4920 for Active Lupus Nephritis

NCT05201469

RECRUITING

Registry of Asthma Characterization and Recruitment 3 (RACR3)

NCT05272241

RECRUITING Phase 1

Human Immune Response to Ixodes Scapularis Tick Bites

NCT05036707

RECRUITING

Natural History, Epidemiology and Pathogenesis of Severe HPV-Related Diseases (Neptune)

NCT05026138

RECRUITING

Vaccine Responses to SARS-CoV-2 and Other Emerging Infectious Diseases

NCT05078905

RECRUITING

Natural History of Systemic and Nasal Mucosal Immunity to Influenza and SARS-CoV-2 in Adults After Vaccination

NCT04794829

RECRUITING

Metabolic Profiling of Immune Responses in Immune-mediated Diseases

NCT04864886

RECRUITING

Send-In Sample Collection for Comprehensive Analyses of Innate and Adaptive Immune Responses During Acute COVID-19 and Convalescence

NCT04582903

RECRUITING Phase 2

Belimumab With Rituximab for Primary Membranous Nephropathy

NCT03949855

RECRUITING Phase 1

Safety of Belimumab in People With Idiopathic CD4 Lymphopenia and Autoantibodies (Phoebe)

NCT04097561

RECRUITING

Paradoxical Tuberculosis Reactions in Patients Without HIV Infection

NCT04052022

RECRUITING Phase 3

Best Available Therapy Versus Autologous Hematopoietic Stem Cell Transplant for Multiple Sclerosis (BEAT-MS)

NCT04047628

RECRUITING

Collection of Human Biospecimens for Basic and Clinical Research Into Globin Variants

NCT03937817

RECRUITING

Send-In Sample Collection to Achieve Genetic and Immunologic Characterization of Primary Immunodeficiencies

NCT03610802

RECRUITING Phase 2

Food-Specific and Component IgE Threshold Levels That Predict Food Allergy in People With Elevated Total Serum IgE Levels and Atopic Dermatitis

NCT03835767

RECRUITING Phase 1

Safety and Immunogenicity of Ad4-HIV Envelope Vaccine Vectors in Healthy Volunteers

NCT03878121

RECRUITING Phase 1

Vaginal Microbiome Seeding and Health Outcomes in Cesarean-delivered Neonates.

NCT03298334

RECRUITING

Sample Collection From Healthy Volunteers for Assay Optimization

NCT03538600

RECRUITING

The Mechanistic Biology of Primary Immunodeficiency Disorders

NCT03394053

RECRUITING Phase 1

An Open-Label, Proof of Consent Study of Vorinostat for the Treatment of Mdoerate-to-Severe Crohn s Disease and Maintenance Therapy With Ustekinumab

NCT03167437

RECRUITING Phase 1

Targeting Residual Activity By Precision, Biomarker-Guided Combination Therapies of Multiple Sclerosis (TRAP-MS)

NCT03109288

RECRUITING

NIAID Centralized Sequencing Protocol

NCT03206099

RECRUITING

Natural History, Pathogenesis, and Outcome of Autoinflammatory Diseases (NOMID/CAPS, DIRA, CANDLE, SAVI, NLRC4-MAS, Still'S-like Diseases, and Other Undifferentiated Autoinflammatory Diseases)

NCT02974595

RECRUITING

Screening of Healthy Volunteers for Investigational Antimalarial Drugs, Malaria Vaccines, and Controlled Human Malaria Challenge

NCT02639299

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Phase Distribution

PhaseTrial count
Phase 1 858
Phase 2 433
Phase 3 123
Phase 4 54

What the Pipeline for National Institute of Allergy and Infectious Diseases (NIAID) Shows

According to the ClinicalTrials.gov registry, National Institute of Allergy and Infectious Diseases (NIAID) is linked to 2,006 US clinical trials across every stage of research activity. Of those, 155 studies are currently recruiting, about 8% of the sponsor's indexed portfolio, and 1,642 are already marked complete, representing roughly 82% of the total.

The phase mix for National Institute of Allergy and Infectious Diseases (NIAID) reports 177 late-stage studies (Phase 3 and Phase 4 combined) and 1,291 earlier-phase studies (Phase 1 and Phase 2).

The top therapeutic focus area indexed for National Institute of Allergy and Infectious Diseases (NIAID) is HIV Infections with 195 linked trials, and 9 other condition areas appear in the top list above.

How to read these pipeline numbers

Recruiting share is one of the more practical signals here: it reflects how much of a sponsor's research is presently open to new participants, while the completed share indicates the depth of finished work that has already contributed registry results. Both counts come directly from the public ClinicalTrials.gov dataset and are refreshed on the registry side; this page mirrors the latest data pull without altering it.

A portfolio weighted toward Phase 3 usually reflects an organization advancing candidates toward regulatory review, where the research centers on comparative efficacy and broader safety across larger populations. A heavier Phase 1 and Phase 2 tilt generally indicates exploratory work, safety, dosing, and early signal detection, and is common among research-forward sponsors that seed many early programs. Phase 4 entries, when present, track interventions already in real-world use and typically focus on long-term safety, effectiveness across subgroups, or formulation comparisons.

That distribution is a quick read of where the organization concentrates its research attention; it does not imply product availability, market share, or any clinical endorsement. All numbers on this page come from ClinicalTrials.gov maintained by the National Library of Medicine, and counts can shift as new studies are registered or existing ones update their status. This information is provided for reference and educational purposes only, not as medical, investment, or regulatory advice, verify current details directly with ClinicalTrials.gov before relying on any figure here.

Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial from this sponsor, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.