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ClinicalTrials.gov 2 recruiting now official registry

Tuberculosis clinical trials

Every US clinical trial registered for Tuberculosis — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.

30 US clinical trials · 2 currently recruiting

The research picture

Tuberculosis has 30 registered US clinical trials, 2 of them open to new participants right now — about 7% of the total.

2
recruiting participants now
7%
of trials open to enrollment
1
in Phase 3–4 (later-stage)
13
top sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.

Active & Recent Trials

RECRUITING 150 participants

Training Protocol on the Natural History of Tuberculosis

National Institute of Allergy and Infectious Diseases (NIAID)

NCT01212003

RECRUITING 140 participants

Paradoxical Tuberculosis Reactions in Patients Without HIV Infection

National Institute of Allergy and Infectious Diseases (NIAID)

NCT04052022

ACTIVE NOT RECRUITING 200 participants

PREVAIL VIIIa: Evaluation of Latent Tuberculosis Infection Screening Methods in People Living With Retroviral Infection in Liberia

National Institute of Allergy and Infectious Diseases (NIAID)

NCT04926922

COMPLETED 21,334 participants

Prospective Comparison of the Tuberculin Skin Test and Interferon-Gamma Release Assays in Diagnosing Infection With Mycobacterium Tuberculosis and in Predicting Progression to Tuberculosis

Centers for Disease Control and Prevention

NCT01622140

COMPLETED 1,509 participants

A Registry of Tuberculosis Cases in the CPCRA

National Institute of Allergy and Infectious Diseases (NIAID)

NCT00000785

COMPLETED Phase 3 876 participants

Nutrition, Immunology and Epidemiology of Tuberculosis

Harvard School of Public Health (HSPH)

NCT00197704

COMPLETED Phase 2 433 participants

TBTC Study 28: Moxifloxacin Versus Isoniazid for TB Treatment

Centers for Disease Control and Prevention

NCT00144417

COMPLETED 268 participants

Evaluation of the QuantiFERON-TB Test.

QIAGEN Gaithersburg

NCT02256839

COMPLETED NA 263 participants

Effectiveness of Public Health Model of Latent Tuberculosis Infection Control for High-Risk Adolescents

San Diego State University

NCT00233168

COMPLETED NA 215 participants

TBTC Study 23: Treatment of HIV-Related Tuberculosis Using a Rifabutin-Based Regimen

Centers for Disease Control and Prevention

NCT00023361

COMPLETED 215 participants

Sputum Pharmacokinetics of TB Drugs and Bacterial Drug Resistance

National Institute of Allergy and Infectious Diseases (NIAID)

NCT02534727

COMPLETED 205 participants

Pharmacokinetic Properties of Antiretroviral and Anti-Tuberculosis Drugs During Pregnancy and Postpartum

National Institute of Allergy and Infectious Diseases (NIAID)

NCT04518228

COMPLETED 150 participants

Urine Colorimetry for Tuberculosis Pharmacokinetics Evaluation in Children and Adults

University of Virginia

NCT05283967

COMPLETED 145 participants

Behavioral Interventions for Control of TB

Columbia University

NCT00005739

COMPLETED 135 participants

Is Tuberculin Skin Testing Effective in Screening for Latent Tuberculosis (TB) in Elderly Residents of Nursing Homes?

Northwell Health

NCT00756808

COMPLETED Phase 2 122 participants

Pharmacokinetic Study to Evaluate Double-Dose Levonorgestrel Emergency Contraception in Combination With Efavirenz-Based Antiretroviral Therapy or Rifampicin-Containing Anti-Tuberculosis Therapy

Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections

NCT03819114

COMPLETED NA 98 participants

TBTC Study 24: Intermittent Treatment of TB With Isoniazid Resistance or Intolerance

Centers for Disease Control and Prevention

NCT00023374

COMPLETED 96 participants

Gene Expression in HIV and Tuberculosis Co-infection

National Institute of Allergy and Infectious Diseases (NIAID)

NCT01611402

COMPLETED Phase 1 92 participants

Challenge Model for Assessment of Human TB Immunity

National Institute of Allergy and Infectious Diseases (NIAID)

NCT01868464

COMPLETED Phase 1 70 participants

Early Bactericidal Activity of Linezolid, Gatifloxacin, Levofloxacin, Isoniazid (INH) and Moxifloxacin in HIV Negative Adults With Initial Episodes of Sputum Smear-Positive Pulmonary Tuberculosis

National Institute of Allergy and Infectious Diseases (NIAID)

NCT00396084

COMPLETED Phase 1 62 participants

Escalating Single-dose Safety, Tolerability, and Pharmacokinetics of SQ109 in Healthy Volunteers

Sequella

NCT01585636

COMPLETED Phase 1 59 participants

Phase I Trial of DAR-901

Dartmouth-Hitchcock Medical Center

NCT02063555

COMPLETED Phase 1 48 participants

A Phase 1 Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of TBA-354 in Healthy Adult Subjects

Global Alliance for TB Drug Development

NCT02288481

COMPLETED Phase 1 44 participants

A Pilot Study of Methodology to Rapidly Evaluate Drugs for Bactericidal Activity, Tolerance, and Pharmacokinetics in the Treatment of Pulmonary Tuberculosis Using Isoniazid and Levofloxacin

National Institute of Allergy and Infectious Diseases (NIAID)

NCT00000778

COMPLETED 40 participants

Expression of Tuberculosis in the Lung

University of Medicine and Dentistry of New Jersey

NCT00201253

COMPLETED Phase 1 37 participants

Safety, Tolerability, and Effect of TMC207 and Efavirenz in Healthy Volunteers

National Institute of Allergy and Infectious Diseases (NIAID)

NCT00992069

COMPLETED Phase 1 28 participants

A Phase 1, Drug-Drug Interaction Study of TBAJ-876 in Healthy Adults

Global Alliance for TB Drug Development

NCT05526911

COMPLETED Phase 1 28 participants

Study to Evaluate Safety, Tolerability, and the PK Profile of TBI-223 in Healthy Subjects

Global Alliance for TB Drug Development

NCT04865536

COMPLETED Phase 2 24 participants

A Clinical Trial of the Safety, Pharmacokinetics and Hematologic Effects of Imatinib on Myelopoiesis in Adults When Given With and Without Isoniazid and Rifabutin

National Institute of Allergy and Infectious Diseases (NIAID)

NCT03891901

COMPLETED Phase 1 12 participants

Single-Dose Study to Evaluate the PKs of Pretomanid in Participants With Renal Impairment Compared to Participants With Normal Renal Function

National Institute of Allergy and Infectious Diseases (NIAID)

NCT03896750

Reading the Tuberculosis Trial Landscape

ClinicalTrials.gov lists 30 US studies indexed under Tuberculosis, and 2 of those are currently open to recruitment — roughly 7% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Tuberculosis shows 1 late-stage studies (Phase 3 and Phase 4 combined) alongside 13 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Tuberculosis is led by National Institute of Allergy and Infectious Diseases (NIAID) with 13 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 30 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Tuberculosis?

PlainTrial tracks 30 US clinical trials for Tuberculosis, of which 2 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Tuberculosis?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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