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Tuberculosis clinical trials
Every US clinical trial registered for Tuberculosis — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.
30 US clinical trials · 2 currently recruiting
The research picture
Tuberculosis has 30 registered US clinical trials, 2 of them open to new participants right now — about 7% of the total.
- 2
- recruiting participants now
- 7%
- of trials open to enrollment
- 1
- in Phase 3–4 (later-stage)
- 13
- top sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.
Active & Recent Trials
Training Protocol on the Natural History of Tuberculosis
National Institute of Allergy and Infectious Diseases (NIAID)
NCT01212003
Paradoxical Tuberculosis Reactions in Patients Without HIV Infection
National Institute of Allergy and Infectious Diseases (NIAID)
NCT04052022
PREVAIL VIIIa: Evaluation of Latent Tuberculosis Infection Screening Methods in People Living With Retroviral Infection in Liberia
National Institute of Allergy and Infectious Diseases (NIAID)
NCT04926922
Prospective Comparison of the Tuberculin Skin Test and Interferon-Gamma Release Assays in Diagnosing Infection With Mycobacterium Tuberculosis and in Predicting Progression to Tuberculosis
Centers for Disease Control and Prevention
NCT01622140
A Registry of Tuberculosis Cases in the CPCRA
National Institute of Allergy and Infectious Diseases (NIAID)
NCT00000785
Nutrition, Immunology and Epidemiology of Tuberculosis
Harvard School of Public Health (HSPH)
NCT00197704
TBTC Study 28: Moxifloxacin Versus Isoniazid for TB Treatment
Centers for Disease Control and Prevention
NCT00144417
Evaluation of the QuantiFERON-TB Test.
QIAGEN Gaithersburg
NCT02256839
Effectiveness of Public Health Model of Latent Tuberculosis Infection Control for High-Risk Adolescents
San Diego State University
NCT00233168
TBTC Study 23: Treatment of HIV-Related Tuberculosis Using a Rifabutin-Based Regimen
Centers for Disease Control and Prevention
NCT00023361
Sputum Pharmacokinetics of TB Drugs and Bacterial Drug Resistance
National Institute of Allergy and Infectious Diseases (NIAID)
NCT02534727
Pharmacokinetic Properties of Antiretroviral and Anti-Tuberculosis Drugs During Pregnancy and Postpartum
National Institute of Allergy and Infectious Diseases (NIAID)
NCT04518228
Urine Colorimetry for Tuberculosis Pharmacokinetics Evaluation in Children and Adults
University of Virginia
NCT05283967
Behavioral Interventions for Control of TB
Columbia University
NCT00005739
Is Tuberculin Skin Testing Effective in Screening for Latent Tuberculosis (TB) in Elderly Residents of Nursing Homes?
Northwell Health
NCT00756808
Pharmacokinetic Study to Evaluate Double-Dose Levonorgestrel Emergency Contraception in Combination With Efavirenz-Based Antiretroviral Therapy or Rifampicin-Containing Anti-Tuberculosis Therapy
Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections
NCT03819114
TBTC Study 24: Intermittent Treatment of TB With Isoniazid Resistance or Intolerance
Centers for Disease Control and Prevention
NCT00023374
Gene Expression in HIV and Tuberculosis Co-infection
National Institute of Allergy and Infectious Diseases (NIAID)
NCT01611402
Challenge Model for Assessment of Human TB Immunity
National Institute of Allergy and Infectious Diseases (NIAID)
NCT01868464
Early Bactericidal Activity of Linezolid, Gatifloxacin, Levofloxacin, Isoniazid (INH) and Moxifloxacin in HIV Negative Adults With Initial Episodes of Sputum Smear-Positive Pulmonary Tuberculosis
National Institute of Allergy and Infectious Diseases (NIAID)
NCT00396084
Escalating Single-dose Safety, Tolerability, and Pharmacokinetics of SQ109 in Healthy Volunteers
Sequella
NCT01585636
Phase I Trial of DAR-901
Dartmouth-Hitchcock Medical Center
NCT02063555
A Phase 1 Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of TBA-354 in Healthy Adult Subjects
Global Alliance for TB Drug Development
NCT02288481
A Pilot Study of Methodology to Rapidly Evaluate Drugs for Bactericidal Activity, Tolerance, and Pharmacokinetics in the Treatment of Pulmonary Tuberculosis Using Isoniazid and Levofloxacin
National Institute of Allergy and Infectious Diseases (NIAID)
NCT00000778
Expression of Tuberculosis in the Lung
University of Medicine and Dentistry of New Jersey
NCT00201253
Safety, Tolerability, and Effect of TMC207 and Efavirenz in Healthy Volunteers
National Institute of Allergy and Infectious Diseases (NIAID)
NCT00992069
A Phase 1, Drug-Drug Interaction Study of TBAJ-876 in Healthy Adults
Global Alliance for TB Drug Development
NCT05526911
Study to Evaluate Safety, Tolerability, and the PK Profile of TBI-223 in Healthy Subjects
Global Alliance for TB Drug Development
NCT04865536
A Clinical Trial of the Safety, Pharmacokinetics and Hematologic Effects of Imatinib on Myelopoiesis in Adults When Given With and Without Isoniazid and Rifabutin
National Institute of Allergy and Infectious Diseases (NIAID)
NCT03891901
Single-Dose Study to Evaluate the PKs of Pretomanid in Participants With Renal Impairment Compared to Participants With Normal Renal Function
National Institute of Allergy and Infectious Diseases (NIAID)
NCT03896750
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 10 |
| Phase 2 | 3 |
| Phase 3 | 1 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Tuberculosis Trial Landscape
ClinicalTrials.gov lists 30 US studies indexed under Tuberculosis, and 2 of those are currently open to recruitment — roughly 7% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
The phase distribution for Tuberculosis shows 1 late-stage studies (Phase 3 and Phase 4 combined) alongside 13 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
Top sponsor activity for Tuberculosis is led by National Institute of Allergy and Infectious Diseases (NIAID) with 13 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 30 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Tuberculosis?
PlainTrial tracks 30 US clinical trials for Tuberculosis, of which 2 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Tuberculosis?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology — how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.