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NCT06280950 · ClinicalTrials.gov registry record · Phase 2
Expanding Liver Transplant Immunosuppression Minimization Via Everolimus
A Phase 2 study of Liver Transplant, sponsored by National Institute of Allergy and Infectious Diseases (NIAID).
- Recruiting
- Registry status
- Phase 2
- Development phase
- 340
- Enrollment target
- 8
- Study locations
NCT06280950: Recruiting Phase 2 study of Liver Transplant, sponsored by National Institute of Allergy and Infectious Diseases (NIAID).
NCT06280950 is a Phase 2 study of Liver Transplant that is actively recruiting participants, run by National Institute of Allergy and Infectious Diseases (NIAID). The registered enrollment target is 340 participants, below the 5,440-participant average among 19 other Liver Transplant trials with a reported enrollment target (94% lower). The trial reports 8 study locations across 7 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06280950, a Phase 2 study of Liver Transplant, is actively recruiting participants, sponsored by National Institute of Allergy and Infectious Diseases (NIAID).
- RECRUITING
- Registry status
- Phase 2
- Development phase
- 340 participants
- Enrollment target
- 8
- Study locations
Study Summary
This is a study to determine the safety, efficacy, and tolerability of taking away the anti-rejection medicine, tacrolimus, in liver transplant recipients in conjunction with everolimus monotherapy to preserve renal function. Two hundred - seventy (270) subjects will be randomized 2:1 into one of two groups between 2-3 months post-transplant. Seventy participants will be placed into an observational group and will remain on their current post-transplant medications. The duration of the study from time of enrollment is 18-20 months.
Conditions Studied
Interventions
- DRUG Everolimus
- DRUG Tacrolimus (continued reduction)
- DRUG Tacrolimus (maintain 50% reduction)
Study Locations (8)
Pennsylvania
- University of Pennsylvania (Site #: 71111) - Philadelphia
- University of Pittsburgh Medical Center (Site #: 71170) - Pittsburgh
Arizona
- Mayo Clinic Hospital Arizona (Site #: 71144) - Phoenix
California
- University of California, San Francisco (Site #: 71108) - San Francisco
Illinois
- Northwestern University (Site #: 71110) - Chicago
New York
- Icahn School of Medicine at Mount Sinai (Site #: 71115) - New York
North Carolina
- Duke University Medical Center (Site #: 71139) - Durham
Texas
- Baylor Medical Center (Site #: 71153) - Dallas
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 340 participants |
| Start Date | 2024-09-12 |
| Est. Completion | 2029-06-01 |
| Phase | Phase 2 |
What NCT06280950 shows while recruiting
NCT06280950 is an interventional study that assigns participants to a tested intervention. The registered 340 participants enrollment target is mid-sized for trials with a published cap, below the 5,440-participant average among 19 other Liver Transplant trials with a reported enrollment target (94% lower).
The record links to 1 condition, with Liver Transplant appearing as the primary indexed condition, and to 3 interventions - of which Everolimus is the first listed.
NCT06280950 lists 8 locations in 7 states (Pennsylvania, Arizona, California).
Frequently Asked Questions
What is clinical trial NCT06280950 about?
NCT06280950 is a clinical study titled "Expanding Liver Transplant Immunosuppression Minimization Via Everolimus". This is a study to determine the safety, efficacy, and tolerability of taking away the anti-rejection medicine, tacrolimus, in liver transplant recipients in conjunction with everolimus monotherapy to preserve renal function. Two hundred - seventy (270) subjects will be randomized 2:1 into one of tw...
What is the current status of trial NCT06280950?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 340 participants. The study started on 2024-09-12. Estimated completion is 2029-06-01.
What conditions does trial NCT06280950 study?
This clinical trial studies the following conditions: Liver Transplant.
What interventions are being tested in trial NCT06280950?
The interventions under investigation include: Everolimus (DRUG), Tacrolimus (continued reduction) (DRUG), Tacrolimus (maintain 50% reduction) (DRUG).
Who is sponsoring clinical trial NCT06280950?
This trial is sponsored by National Institute of Allergy and Infectious Diseases (NIAID), which has 2,006 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06280950 being conducted?
This trial has 8 study locations across Arizona, California, Illinois, New York, North Carolina. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Liver Transplant
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06280950's enrollment target sits among peer trials
340 6th of 19 higher than 14 of 19 other Liver Transplant trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Liver Transplant trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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