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Cytomegalovirus (CMV) Vaccine in Orthotopic Liver Transplant Candidates
NCT06075745 · View on ClinicalTrials.gov ↗
Study Summary
This is a multi-center clinical trial in Cytomegalovirus (CMV) seronegative prospective liver transplant recipients to determine the efficacy of two doses of Cytomegalovirus-Modified Vaccinia Ankara (CMV-MVA) Triplex CMV vaccine pre-transplant. The primary objective is to assess the effect of pre-transplant (Tx) Triplex vaccination on duration of CMV antiviral therapy (AVT) within the first 100 days post-Tx in CMV seropositive donor (D+) and seronegative (R-) (D+R-) liver transplant recipients (LTxRs). A protocol-mandated preemptive therapy (PET) will be used for CMV disease prevention in D+R- LTxRs.
Conditions Studied
Interventions
- DRUG CMV-MVA Triplex
- DRUG Placebo for CMV-MVA Triplex
Study Locations (18)
California
- University of California, San Diego School of Medicine — La Jolla
- Stanford University — Redwood City
- University of California, San Francisco — San Francisco
Pennsylvania
- University of Pennsylvania School of Medicine — Philadelphia
- University of Pittsburgh Medical Center — Pittsburgh
Alabama
- University of Alabama at Birmingham, School of Medicine — Birmingham
Florida
- University of Miami, Jackson Memorial Hospital — Miami
Georgia
- Emory University Hospital — Atlanta
Illinois
- Northwestern University, Feinberg School of Medicine — Chicago
Maryland
- Johns Hopkins University School of Medicine — Baltimore
Michigan
- University of Michigan Medical Center — Ann Arbor
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 416 participants |
| Start Date | 2024-03-05 |
| Est. Completion | 2028-02-28 |
| Phase | Phase 2 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06075745
The ClinicalTrials.gov registry entry for NCT06075745 describes a study currently listed as recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 416 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is National Institute of Allergy and Infectious Diseases (NIAID), which has 1,295 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with Liver Transplant appearing as the primary indexed condition, and to 2 interventions — of which CMV-MVA Triplex is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT06075745 reports 18 study locations spanning 15 distinct geographic areas — top geographies include California, Pennsylvania, Alabama. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT06075745 about?
NCT06075745 is a clinical study titled "Cytomegalovirus (CMV) Vaccine in Orthotopic Liver Transplant Candidates". This is a multi-center clinical trial in Cytomegalovirus (CMV) seronegative prospective liver transplant recipients to determine the efficacy of two doses of Cytomegalovirus-Modified Vaccinia Ankara (CMV-MVA) Triplex CMV vaccine pre-transplant. The primary objective is to assess the effect of pre-tr...
What is the current status of trial NCT06075745?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 416 participants. The study started on 2024-03-05. Estimated completion is 2028-02-28.
What conditions does trial NCT06075745 study?
This clinical trial studies the following conditions: Liver Transplant. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT06075745?
The interventions under investigation include: CMV-MVA Triplex (DRUG), Placebo for CMV-MVA Triplex (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT06075745?
This trial is sponsored by National Institute of Allergy and Infectious Diseases (NIAID), which has 1,295 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT06075745 being conducted?
This trial has 18 study locations across Alabama, California, Florida, Georgia, Illinois. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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