Merck Sharp & Dohme

558 total trials 120 currently recruiting 320 completed

Merck Sharp & Dohme sponsors 558 registered US clinical trials on ClinicalTrials.gov, 120 of them currently recruiting, and 320 completed. 191 of these trials are in Phase 3-4 (later-stage) and 360 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Healthy, with 25 trials.

Trial Pipeline

558 total, page 11 of 12

COMPLETED Phase 2

Study of Sotatercept for the Treatment of Anemia in low-or Intermediate-1 Risk Myelodysplastic Syndromes (MDS) or Non-proliferative Chronic Myelomonocytic Leukemia (CMML)

NCT01736683

COMPLETED Phase 1

A Study of the Effect of MK-8457 on Blood Pressure in Hypertensive Participants (MK-8457-004-AM1)

NCT01446003

COMPLETED Phase 1

Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of MK-1029 in Participants With Mild to Moderate Asthma

NCT01370317

COMPLETED Phase 1

A Study to Evaluate and Compare the Efficacy and Pharmacokinetics of MK-0873 for the Treatment of Plaque Psoriasis (MK-0873-022)

NCT01235728

TERMINATED Phase 2

A Four Week, Open-Label Study of Azithromycin Ophthalmic Solution, 1% (P08641)

NCT01220258

TERMINATED Phase 2

Study to Evaluate Effect of a Single Dose of Sotatercept (ACE-011) on Red Blood Cell Mass and Plasma Volume in Participants With Solid Tumors

NCT01190644

COMPLETED Phase 4

A Four Week Study of Azithromycin Ophthalmic Solution, 1% Versus Rewetting Drops in Subjects With History and Current Complaint of Contact Lens-Related Dry Eye (CLDE)

NCT01105624

COMPLETED Phase 4

A Four Week Study of Azithromycin Ophthalmic Solution, 1% Versus Placebo in Subjects With Dry Eye Disease

NCT01014078

TERMINATED Phase 2

Study of Sotatercept for the Treatment of Chemotherapy Induced Anemia in Patients With Metastatic Breast Cancer (MK-7962-012)

NCT00931606

COMPLETED Phase 2

The Effects of Azithromycin Ophthalmic Solution, 1% Versus Placebo in Subjects With Blepharitis During a Four-Week Treatment Period (P08638)

NCT00894530

COMPLETED Phase 2

The Effects of Azithromycin Ophthalmic Solution, 1% Versus Placebo in Subjects With Blepharitis During a Two-Week Treatment Period

NCT00892970

COMPLETED Phase 1

A Study of Aprepitant (MK-0869) in Pediatric Participants Undergoing Surgery (MK-0869-148)

NCT00819039

COMPLETED Phase 4

Safety and Efficacy Pilot Study of AzaSite® for Four Weeks in Subjects With Blepharitis

NCT00656539

COMPLETED Phase 4

Safety and Efficacy Study of AzaSite® in Subjects With Blepharitis

NCT00629941

COMPLETED Phase 4

Safety and Efficacy Pilot Study of AzaSite (Azithromycin) in Subjects With Blepharitis

NCT00629590

COMPLETED Phase 4

Study of AzaSite Versus Vigamox in the Tears of Healthy Volunteers

NCT00575367

COMPLETED Phase 4

Safety and Efficacy Pilot Study of AzaSite® (Azithromycin) in Subjects With Blepharitis

NCT00629980

COMPLETED Phase 3

Study of Denufosol Tetrasodium Inhalation Solution in Patients With Cystic Fibrosis (CF) Lung Disease

NCT00625612

COMPLETED Phase 4

Study of AzaSite Versus Vigamox Concentrations in the Conjunctiva and Aqueous Humor in Subjects Undergoing Routine Cataract Surgery

NCT00575380

COMPLETED Phase 4

Study of Two Marketed Ocular Anti-Allergy Medications in Subjects With Allergic Conjunctivitis

NCT00534794

COMPLETED Phase 2

A Study of Epinastine Nasal Spray in Subjects With Seasonal Allergic Rhinitis

NCT00407927

COMPLETED Phase 2

Study to Evaluate Drug-drug Interaction Between Valopicitabine and Ribavirin

NCT00395421

TERMINATED Phase 2

A 52-Week Study to Assess the Effects of MK0822 on Knee Osteoarthritis (MK-0822-011)

NCT00397683

COMPLETED Phase 3

Safety and Efficacy of Prulifloxacin Versus Placebo in Traveler's Diarrhea

NCT00392574

TERMINATED Phase 2

Study of INS50589 Intravenous Infusion in Subjects Undergoing Coronary Artery Bypass Grafting (CABG) Involving Cardiopulmonary Bypass

NCT00316212

COMPLETED Phase 2

A Study to Evaluate the Combination of Pegylated Interferon Alfa Plus Valopicitabine in Patients With Hepatitis C

NCT00118768

COMPLETED Phase 2

A Study in Pediatric Patients With Cystic Fibrosis Lung Disease

NCT00130182

COMPLETED Phase 2

Ridaforolimus (AP23573/MK-8669) in Participants With Taxane-Resistant Androgen-Independent Prostate Cancer (AIPC)(MK-8669-017)

NCT00110188

COMPLETED Phase 2

Valopicitabine Alone and Together With Pegylated Interferon in Patients With Chronic Hepatitis C Who Have Failed to Respond to Standard Therapy

NCT00120861

COMPLETED Phase 1

Study of the Tolerability, Pharmacokinetics, and Pharmacodynamics of INS50589 Intravenous Infusion in Healthy Volunteers

NCT00099450

COMPLETED Phase 3

Evaluation of Clinical and Microbial Efficacy and Safety of AzaSite Compared to Tobramycin for Bacterial Conjunctivitis (C-01-401-004)

NCT00105469

COMPLETED Phase 3

Evaluation of Clinical and Microbial Efficacy and Safety of AzaSite Compared to Vehicle for Bacterial Conjunctivitis (C-01-401-003)

NCT00105534

COMPLETED Phase 1

Valopicitabine When Administered Alone and in Combination With Interferon to Treatment-Naive Patients With Hepatitis C

NCT00120835

COMPLETED Phase 1

Safety Study of AP23573 in Patients With Progressive or Recurrent Glioma (8669-023)(COMPLETED)

NCT00087451

COMPLETED Phase 2

Study of AP23573 in Patients With Relapsed or Refractory Hematologic Malignancies (8669-024)(COMPLETED)

NCT00086125

TERMINATED Phase 2

Study of Denufosol (INS37217) in Subjects With Rhegmatogenous Retinal Detachment

NCT00083967

COMPLETED Phase 1

Safety Study of AP23573 in Patients With Advanced, Refractory or Recurrent Malignancies (8669-013)(COMPLETED)

NCT00060645

COMPLETED Phase 1

Dose Escalation Study to Evaluate the Safety and Antiviral Activity of Val-mCyd in Adults With Chronic Hepatitis C

NCT00227435

COMPLETED Phase 2

MARS - Monitored Atherosclerosis Regression Study

NCT00116870

COMPLETED Phase 1

A Pharmacokinetic Study of L-697,661 Alone and in Combination With Zidovudine

NCT00000628

COMPLETED NA

A Study of the Side Effects of L-743,872 in Men With Candidal Esophagitis

NCT00005921

COMPLETED NA

The Safety and Effectiveness of Indinavir Sulfate Plus Efavirenz

NCT00002387

COMPLETED NA

A Six-Month Safety and Antiviral Study in HIV-1 Seropositive, AZT-Experienced Patients With CD4 Counts Less Than or Equal to 50 Cells/mm3 to Evaluate MK-639 Alone Versus Zidovudine (AZT) and 3TC Versus the Combination of MK-639 With AZT/3TC

NCT00002155

COMPLETED Phase 2

Safety and Effectiveness of an Anti-HIV Drug Combination in HIV-Positive Patients Who Have Failed Previous Treatment With Protease Inhibitors

NCT00002361

COMPLETED Phase 1

A Study of L-735,524 in HIV-Positive Children and Adolescents

NCT00002351

COMPLETED NA

Safety and Effectiveness of Giving Indinavir and Nelfinavir to HIV-Infected Patients

NCT00002375

COMPLETED NA

A Study of Indinavir Sulfate Given Together With Stavudine to HIV-Positive Patients

NCT00002354

COMPLETED NA

A Study to Compare the Effectiveness of Two Anti-HIV Drug Combinations

NCT00002430

COMPLETED Phase 3

A Multicenter, Open-Label, Randomized, 24-Week Study to Compare the Safety and Activity of Indinavir Sulfate, 800 Mg q 8 h Versus 1,200 Mg q 12 h in Combination With Zidovudine and 3TC

NCT00002208

COMPLETED Phase 3

A Comparison of Two Dose Levels of Indinavir Combined With Two Nucleoside Analogue Reverse Transcriptase Inhibitors (NRTIs) in HIV-Infected Patients

NCT00002406

← Previous Page 11 of 12 Next →

Phase Distribution

PhaseTrial count
Phase 1 230
Phase 2 130
Phase 3 173
Phase 4 18

What the Pipeline for Merck Sharp & Dohme Shows

According to the ClinicalTrials.gov registry, Merck Sharp & Dohme is linked to 558 US clinical trials across every stage of research activity. Of those, 120 studies are currently recruiting, about 22% of the sponsor's indexed portfolio, and 320 are already marked complete, representing roughly 57% of the total.

The phase mix for Merck Sharp & Dohme reports 191 late-stage studies (Phase 3 and Phase 4 combined) and 360 earlier-phase studies (Phase 1 and Phase 2).

The top therapeutic focus area indexed for Merck Sharp & Dohme is Healthy with 25 linked trials, and 9 other condition areas appear in the top list above.

How to read these pipeline numbers

Recruiting share is one of the more practical signals here: it reflects how much of a sponsor's research is presently open to new participants, while the completed share indicates the depth of finished work that has already contributed registry results. Both counts come directly from the public ClinicalTrials.gov dataset and are refreshed on the registry side; this page mirrors the latest data pull without altering it.

A portfolio weighted toward Phase 3 usually reflects an organization advancing candidates toward regulatory review, where the research centers on comparative efficacy and broader safety across larger populations. A heavier Phase 1 and Phase 2 tilt generally indicates exploratory work, safety, dosing, and early signal detection, and is common among research-forward sponsors that seed many early programs. Phase 4 entries, when present, track interventions already in real-world use and typically focus on long-term safety, effectiveness across subgroups, or formulation comparisons.

That distribution is a quick read of where the organization concentrates its research attention; it does not imply product availability, market share, or any clinical endorsement. All numbers on this page come from ClinicalTrials.gov maintained by the National Library of Medicine, and counts can shift as new studies are registered or existing ones update their status. This information is provided for reference and educational purposes only, not as medical, investment, or regulatory advice, verify current details directly with ClinicalTrials.gov before relying on any figure here.

Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial from this sponsor, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.