Mayo Clinic

Open enrollment with an early-phase pipeline tilt

According to ClinicalTrials.gov-derived indexes, Mayo Clinic sits in the top decile of US sponsors by registered trial count (#2 of 15,751 sponsors by registered trial count).

2,844 total trials 544 currently recruiting 1816 completed early-phase tilt top decile by trial count

Mayo Clinic: 2,844 sponsored US clinical trials, 544 recruiting.

Mayo Clinic sponsors 2,844 registered US clinical trials on ClinicalTrials.gov, 544 of them currently recruiting, and 1,816 completed. 252 of these trials are in Phase 3-4 (later-stage) and 821 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Healthy, with 36 trials.

Top-decile sponsor footprint

Mayo Clinic ranks in the top decile of sponsors by registered trial count (#2 of 15,751 sponsors by registered trial count). Volume at this scale usually reflects a long institutional pipeline, read phase tilt and therapeutic areas below before treating it as current-year activity.

Open and recent trials

2,844 total, page 15 of 57

NOT YET RECRUITING NA

Sequential, Multiple Assignment, Double Randomized Preference, Migraine Behavioral Trial

NCT06170281

NOT YET RECRUITING Phase 1

ABBV-383 for the Treatment of Relapsed Refractory Waldenström Macroglobulinemia

NCT07420959

NOT YET RECRUITING Phase 2

The Effect of rs7903146 Genotype on Islet GLP-1 Production in Humans

NCT06972407

NOT YET RECRUITING NA

HAIQU (Hospital AIr QUality)

NCT07670117

NOT YET RECRUITING NA

A Physical Activity Program Compared to Health Education for Improving Memory and Attention in Hispanic Women With Newly-Diagnosed Stage I-IIIa Breast Cancer, MAMA Trial

NCT07331077

NOT YET RECRUITING NA

A Study for Cerebral Open Flow Microperfusion

NCT07089758

NOT YET RECRUITING

Self-Collection for Cervical Cancer Screening and HPV Vaccination for Cancer Prevention Among Women in Emergency Care in Northeast Florida

NCT06607874

NOT YET RECRUITING Phase 2

HRX215, A First Generation MKK4 Inhibitor Drug, for the Treatment of Patients With Colorectal Liver Metastasis After Undergoing a Portal Vein Embolization

NCT07612007

NOT YET RECRUITING NA

Mechanisms of Resistance Exercise Training for Improved Muscle Insulin Sensitivity

NCT07128368

NOT YET RECRUITING

Hand Perfusion and Pulse Oximetry Performance

NCT06925646

NOT YET RECRUITING NA

Flyte Device for Improving Urinary Incontinence Among Endometrial and Cervical Cancer Survivors Who Have Undergone Radiation Therapy

NCT07662824

NOT YET RECRUITING Phase 4

Low Dose Aspirin to Lower Inflammation and Prevent Endometrial Cancer in Postmenopausal Women With Non-atrophic Endometrial Changes and Pain

NCT07281547

NOT YET RECRUITING NA

Meaning-Centered Psychotherapy for Addressing Existential Distress of Patient/Caregiver Dyads Following Hematopoietic Stem Cell Transplantation: Feasibility and Acceptability

NCT07595146

NOT YET RECRUITING

A Study of Microcirculatory Function in Type 2 Myocardial Infarction (T2MI)

NCT05793567

NOT YET RECRUITING NA

MenoZen VR for Menopause Symptom Management: Phase 2

NCT07633743

NOT YET RECRUITING NA

Prospective Evaluation of Physician Modified Endografts for Aortic Disease

NCT07611968

NOT YET RECRUITING

Tumor-Derived Extracellular Vesicles for Noninvasive Molecular Classification of Kidney Cancer

NCT07243067

NOT YET RECRUITING NA

Acute Stimulation and Modulation of Stereotyped High-Frequency Oscillations

NCT06898138

NOT YET RECRUITING Phase 2

Study of PSMA-targeted Therapy and Androgen Receptor Suppression in Low-volume Metastatic ProstatE Cancer: SPARKLE Trial

NCT07650240

NOT YET RECRUITING Phase 4

The Effect Of Lisinopril On Polycythemia

NCT07594535

NOT YET RECRUITING Phase 4

Bimzelx (Bimekizumab) For The Treatment Of Adult Onset PRP

NCT07497620

NOT YET RECRUITING

Exosome-based Omic Signatures of Disease Activity in Cardiac Sarcoidosis (EXODACS)

NCT07604220

NOT YET RECRUITING Phase 4

A Study of Tris-Hydroxymethyl Aminomethane (THAM) Versus Sodium Bicarbonate in Cardiac Surgical Patients

NCT07424625

NOT YET RECRUITING

Menopausal Hormone Therapy And Left Ventricular Function

NCT07242391

NOT YET RECRUITING NA

A Study Comparing Shoulder Replacement Techniques For Patients With Shoulder Arthritis And An Intact Rotator Cuff

NCT07584356

NOT YET RECRUITING Phase 2

Synthetic THC And Blood Pressure

NCT07231965

NOT YET RECRUITING NA

Cascade Testing In Identifying At-risk Family Members Of Individuals With Familial Hypercholesterolemia (FH) In PCP

NCT07653555

NOT YET RECRUITING Phase 2

THC Versus THC/CBD Versus Placebo to Improve Sleep Quality for Patients With Solid Organ Cancer and Insomnia

NCT07565974

NOT YET RECRUITING NA

A Study Of Phototherapy In Patients With Dementia To Improve BPSD

NCT07488195

NOT YET RECRUITING Phase 2

Axatilimab Plus Standard of Care Therapy for the Prevention of Graft Versus Host Disease Following Allogeneic Hematopoietic Stem Cell Transplantation in Patients With Hematologic Cancer, ABRAXAS Trial

NCT07349771

NOT YET RECRUITING Phase 4

Postoperative Oral Tranexamic Acid in Patients Undergoing Primary Total Joint Arthroplasty

NCT06832878

NOT YET RECRUITING NA

Impact of Insulin Deprivation and Hyperglycemia on Plasma Protein Synthesis in People With Type 1 Diabetes Mellitus

NCT05985135

NOT YET RECRUITING

Use of Shear Wave Elastography for Intraoperative Brain and Tumor Stiffness Measurements

NCT06630338

NOT YET RECRUITING

North American Fetal Therapy Network Prospective Registry for Long-term Outcome Following Fetoscopic Endoluminal Tracheal Occlusion in Severe Left and Right Congenital Diaphragmatic Hernia

NCT07564297

NOT YET RECRUITING NA

A Study Of Acute Decompensated Heart Failure

NCT07572955

NOT YET RECRUITING Phase 4

A Study Of Stellate Ganglion Blockade With Liposomal Bupivacaine In Preventing Atrial Fibrillation After Isolated Coronary Artery Bypass Grafting Surgery

NCT07570940

NOT YET RECRUITING NA

A Study Of Senyo Health With Comorbid Alcohol Use Disorder Treatment In Bipolar Patients

NCT07556861

NOT YET RECRUITING

C11 ER176 PET in Evaluating Neuroinflammation in Patients With Post-COVID Syndrome

NCT07527130

NOT YET RECRUITING NA

Upper Body Subcutaneous Exosome Release in Response to a Meal in Obesity

NCT07031297

NOT YET RECRUITING

Comparison of Ultrasound and Anatomic Landmark Techniques of the Ulnar and Posterior Tibial Nerves

NCT07515911

NOT YET RECRUITING

MCG In Long QT Syndrome

NCT07270211

NOT YET RECRUITING Phase 2

A Study Of Synthetic THC And Sleep

NCT07570953

COMPLETED Phase 4

A Study Of Opioid Avoidance In Surgery Through Integrating Suzetrigine

NCT07257133

COMPLETED NA

Quantitative Transmission Imaging Compared With MRI as Supplemental Screening for High Lifetime Risk of Breast Cancer

NCT07216274

COMPLETED NA

Virtual Reality as a Tool to Lower Blood Pressure and Anxiety in Clinic Settings

NCT06960057

COMPLETED Phase 1

A Study of Varenicline in the Treatment of Visceral Sensation

NCT06854406

COMPLETED NA

Sleeper Stretch in CrossFit Participants

NCT06720155

COMPLETED

Patient Preferences in Empathetic Communication by AI vs Human Authorship

NCT06832891

COMPLETED Phase 4

Oral and Intravenous Methadone for Analgesia in Cardiac Surgery

NCT06720415

COMPLETED

ZTE MRI Pulse Sequence Use for Visualization of Bone Cement, Breast Biopsy Markers

NCT06873802

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Phase Distribution

PhaseTrial count
Phase 1 435
Phase 2 386
Phase 3 86
Phase 4 166

What is open in the Mayo Clinic pipeline

544 recruiting of 2,844 indexed (19% open); 1,816 completed (64%).

Phase mix: 252 late (III/IV) vs 821 early (I/II) (early-phase heavy).

Top condition: Healthy (36 trials), 9 others listed.

How open-pipeline share is computed

Recruiting share is recruiting_count divided by trial_count for this sponsor in the public registry export. Status can change between pulls; treat the figure as a research-attention snapshot, not product availability.

Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial from this sponsor, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.