Mayo Clinic

Open enrollment with an early-phase pipeline tilt

According to ClinicalTrials.gov-derived indexes, Mayo Clinic sits in the top decile of US sponsors by registered trial count (#2 of 15,751 sponsors by registered trial count).

2,844 total trials 544 currently recruiting 1816 completed early-phase tilt top decile by trial count

Mayo Clinic: 2,844 sponsored US clinical trials, 544 recruiting.

Mayo Clinic sponsors 2,844 registered US clinical trials on ClinicalTrials.gov, 544 of them currently recruiting, and 1,816 completed. 252 of these trials are in Phase 3-4 (later-stage) and 821 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Healthy, with 36 trials.

Top-decile sponsor footprint

Mayo Clinic ranks in the top decile of sponsors by registered trial count (#2 of 15,751 sponsors by registered trial count). Volume at this scale usually reflects a long institutional pipeline, read phase tilt and therapeutic areas below before treating it as current-year activity.

Open and recent trials

2,844 total, page 14 of 57

ACTIVE NOT RECRUITING

Clinical Information and Biospecimen Collection From Patients With Recurrent or Stage IV Breast Cancer

NCT03737695

ACTIVE NOT RECRUITING Phase 2

Estradiol in Treating Patients With ER Beta Positive, Triple Negative Locally Advanced or Metastatic Breast Cancer

NCT03941730

ACTIVE NOT RECRUITING Phase 2

Treating Breast Cancer Patients Undergoing Trastuzumab Treatment With Carvedilol to Reduce Incidence of Heart Failure

NCT03879629

ACTIVE NOT RECRUITING NA

Bariatric Surgery Versus Diet Alone in the Bile Acid Pathway and Weight Loss

NCT03238794

ACTIVE NOT RECRUITING NA

Long-Term Transcutaneous Stimulation and Essential Tremor: A PET Study

NCT03778060

ACTIVE NOT RECRUITING NA

Fecal Incontinence Treatment (FIT) Study

NCT03811821

ACTIVE NOT RECRUITING NA

Neurophysiologically Based Brain State Tracking and Modulation in Focal Epilepsy

NCT03946618

ACTIVE NOT RECRUITING Early Phase 1

Ketamine Associated ACC GABA and Glutamate Change and Depression Remission:

NCT03573349

ACTIVE NOT RECRUITING

Utilizing MRI for Earlier Diagnosis of Rheumatoid Arthritis

NCT03841279

ACTIVE NOT RECRUITING NA

Clinical Trial to Assess the Safety of a Novel Scaffold Biomaterial

NCT03584022

ACTIVE NOT RECRUITING Phase 1

Autologous Culture Expanded Adipose Derived MSCs for Treatment of Painful Hip OA

NCT03608579

ACTIVE NOT RECRUITING Phase 2

Vemurafenib, Cobimetinib, Atezolizumab, and Tiragolumab in Treating Patients With High-Risk Stage III Melanoma

NCT03554083

ACTIVE NOT RECRUITING

Identification of Novel High Quality Methylated DNA Markers in Renal Tumors: Whole Methylome Discovery, Tissue Validation, and Feasibility Testing In Blood and Urine, The INQUIRE Study

NCT06339138

ACTIVE NOT RECRUITING

A Study of Photon and Proton Chemoradiotherapy as Definitive or Neoadjuvant Therapy in Non-Metastatic Pancreatic Cancer

NCT03902600

ACTIVE NOT RECRUITING NA

HELP-HY: Health Education and sLeep Program in HYpertension

NCT03255746

ACTIVE NOT RECRUITING Phase 2

Pembrolizumab and Standard Therapy in Treating Patients With Glioblastoma

NCT03197506

ACTIVE NOT RECRUITING

Genetic Analysis in Blood and Tumor Samples From Patients With Advanced or Metastatic Estrogen Receptor Positive and HER2 Negative Breast Cancer Receiving Palbociclib and Endocrine Therapy

NCT03281902

ACTIVE NOT RECRUITING NA

CREST: Capsular Repair During Hip Arthroscopy

NCT03372564

ACTIVE NOT RECRUITING Phase 2

Intrathecal Autologous Adipose-derived Mesenchymal Stromal Cells for Amyotrophic Lateral Sclerosis (ALS)

NCT03268603

ACTIVE NOT RECRUITING Phase 1

VSV-hIFNbeta-NIS With or Without Ruxolitinib Phosphate in Treating Stage IV or Recurrent Endometrial Cancer

NCT03120624

ACTIVE NOT RECRUITING Phase 2

TVB-2640 and Trastuzumab With Paclitaxel or Endocrine Therapy for Treatment of HER2 Positive Metastatic Breast Cancer

NCT03179904

ACTIVE NOT RECRUITING Phase 1

Autologous Adipose Derived Mesenchymal Stem Cells (AMSC) in Reducing Hemodialysis Arteriovenous Fistula Failure

NCT02808208

ACTIVE NOT RECRUITING NA

Ovarian Tissue Cryopreservation in Children

NCT02646384

ACTIVE NOT RECRUITING Phase 1

Pembrolizumab and Ibrutinib in Treating Patients With Stage III-IV Melanoma That Cannot Be Removed by Surgery

NCT03021460

ACTIVE NOT RECRUITING NA

Evaluating Raised Intracranial Pressure Using MR Elastography

NCT03096743

ACTIVE NOT RECRUITING

Evaluation of Neuroendocrine Differentiation as a Potential Mechanism of Tumor Recurrence Following Radiotherapy

NCT03017794

ACTIVE NOT RECRUITING Phase 2

Use of a Squatting Assist Device in Patients With Constipation

NCT02877394

ACTIVE NOT RECRUITING

Neural Circulatory Control and SUDEP Risk.

NCT02813980

ACTIVE NOT RECRUITING NA

Molecular and Structural Imaging in Alzheimer's Disease: A Longitudinal Study

NCT02740634

ACTIVE NOT RECRUITING

Mayo Clinic Radiotherapy Patient Outcomes Registry and Biobanking Study

NCT02457962

ACTIVE NOT RECRUITING Phase 4

Exparel Injection for Postoperative Orbital Pain

NCT02381353

ACTIVE NOT RECRUITING

Extracellular RNA Markers of Liver Disease and Cancer

NCT02908048

ACTIVE NOT RECRUITING Phase 1

MV-NIS Infected Mesenchymal Stem Cells in Treating Recurrent Ovarian, Primary Peritoneal or Fallopian Tube Cancer

NCT02068794

ACTIVE NOT RECRUITING

A Pilot Study Using 18F-DOPA PET-guided Radiotherapy in Gliomas

NCT02104310

ACTIVE NOT RECRUITING

Ventricular Remodeling and Heart Failure After Myocardial Infarction: A Community Study

NCT02047396

ACTIVE NOT RECRUITING

Gene Expression in Patients With Metastatic Prostate Cancer Receiving CYP-17 Inhibition Therapy

NCT01953640

ACTIVE NOT RECRUITING NA

Cholecalciferol in Improving Survival in Patients With Newly Diagnosed Cancer With Vitamin D Insufficiency

NCT01787409

ACTIVE NOT RECRUITING NA

MR-Guided Cryoablation of Prostate Bed Recurrences

NCT01727284

ACTIVE NOT RECRUITING Phase 1

Mesenchymal Stem Cell Therapy in Multiple System Atrophy

NCT02315027

ACTIVE NOT RECRUITING

Collecting Blood and Tissue Samples From Family Members of Patients With Pancreatic Diseases, Pancreatic Cancer, and Melanoma

NCT00835133

NOT YET RECRUITING NA

Virtual Assistant for Plastic Surgery Patients

NCT04017351

NOT YET RECRUITING NA

Evaluation of a Digital Visual Acuity Device vs. Standard Visual Acuity Measurements

NCT06431295

NOT YET RECRUITING NA

A Point of Prostate Cancer Diagnosis Virtual Reality Assistant Intervention in Supporting Newly Diagnosed Black Men

NCT07126548

NOT YET RECRUITING

Evaluation of Prolonged Asparaginase Activity Levels After Calaspargase Pegol Administration

NCT07221656

NOT YET RECRUITING NA

The Effect of Dry Needling With Electrical Stimulation on Individuals With Restless Legs Syndrome

NCT05860751

NOT YET RECRUITING Phase 1

Adipose-Derived Mesenchymal Stem Cell for Preventing Biliary Complications

NCT06649864

NOT YET RECRUITING NA

The Utilization of a Shoe Insert on Individuals With Unilateral Greater Trochanteric Pain Syndrome on Single Leg Stance, Biomechanics, and Pain Intensity

NCT06891001

NOT YET RECRUITING NA

A Study of the Effect of a Nurse Navigator Program on High Risk Patients

NCT05592847

NOT YET RECRUITING

Perioperative Risk in Patients on Chronic Aspirin Undergoing Craniotomy

NCT07086183

NOT YET RECRUITING NA

Minimally Invasive Approaches for the Diagnosis of Barrett's Esophagus and Esophageal Cancer, SOS5C Trial

NCT07206589

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Phase Distribution

PhaseTrial count
Phase 1 435
Phase 2 386
Phase 3 86
Phase 4 166

What is open in the Mayo Clinic pipeline

544 recruiting of 2,844 indexed (19% open); 1,816 completed (64%).

Phase mix: 252 late (III/IV) vs 821 early (I/II) (early-phase heavy).

Top condition: Healthy (36 trials), 9 others listed.

How open-pipeline share is computed

Recruiting share is recruiting_count divided by trial_count for this sponsor in the public registry export. Status can change between pulls; treat the figure as a research-attention snapshot, not product availability.

Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial from this sponsor, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.