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NCT07424625 · ClinicalTrials.gov registry record · Phase 4
A Study of Tris-Hydroxymethyl Aminomethane (THAM) Versus Sodium Bicarbonate in Cardiac Surgical Patients
A Phase 4 study, sponsored by Mayo Clinic.
- Not yet
- Registry status
- Phase 4
- Development phase
- 250
- Enrollment target
NCT07424625: Clinical Trial Phase 4 study, sponsored by Mayo Clinic.
NCT07424625 is a Phase 4 study that has not yet begun recruiting, run by Mayo Clinic. The registered enrollment target is 250 participants, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (52% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07424625, a Phase 4 study, has not yet begun recruiting, sponsored by Mayo Clinic.
- NOT YET RECRUITING
- Registry status
- Phase 4
- Development phase
- 250 participants
- Enrollment target
Study Summary
The purpose of this research is to determine if two commonly used medications to treat metabolic acidosis in the setting of cardiac surgery, sodium bicarbonate and THAM, are equivalent.
Primary Outcome
pH will be measured via arterial blood gas test
Interventions
- DRUG Sodium bicarbonate
- DRUG Tris-hydroxymethyl Aminomethane
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 250 participants |
| Start Date | 2026-07 |
| Est. Completion | 2027-08 |
| Phase | Phase 4 |
What is known before NCT07424625 opens enrollment
NCT07424625 is an interventional study that assigns participants to a tested intervention. The registered 250 participants enrollment target is mid-sized for trials with a published cap, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (52% lower).
The record links to 0 conditions, and to 2 interventions - of which Sodium bicarbonate is the first listed.
NCT07424625 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT07424625 about?
NCT07424625 is a clinical study titled "A Study of Tris-Hydroxymethyl Aminomethane (THAM) Versus Sodium Bicarbonate in Cardiac Surgical Patients". The purpose of this research is to determine if two commonly used medications to treat metabolic acidosis in the setting of cardiac surgery, sodium bicarbonate and THAM, are equivalent.
What is the current status of trial NCT07424625?
This trial is currently not yet recruiting. It is a Phase 4 study. The enrollment target is 250 participants. The study started on 2026-07. Estimated completion is 2027-08.
What interventions are being tested in trial NCT07424625?
The interventions under investigation include: Sodium bicarbonate (DRUG), Tris-hydroxymethyl Aminomethane (DRUG).
Who is sponsoring clinical trial NCT07424625?
This trial is sponsored by Mayo Clinic, which has 2,844 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT07424625's enrollment target sits among peer trials
250 342nd of 2000 higher than 1,648 of 2,000 other Phase 4 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 4 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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