Duke University

Open enrollment with an early-phase pipeline tilt

According to ClinicalTrials.gov-derived indexes, Duke University sits in the top decile of US sponsors by registered trial count (#9 of 15,742 sponsors by registered trial count).

1,725 total trials 187 currently recruiting 1244 completed early-phase tilt top decile by trial count

Duke University: 1,725 sponsored US clinical trials, 187 recruiting.

Duke University sponsors 1,725 registered US clinical trials on ClinicalTrials.gov, 187 of them currently recruiting, and 1,244 completed. 175 of these trials are in Phase 3-4 (later-stage) and 311 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Obesity, with 15 trials.

Top-decile sponsor footprint

Duke University ranks in the top decile of sponsors by registered trial count (#9 of 15,742 sponsors by registered trial count). Volume at this scale usually reflects a long institutional pipeline, read phase tilt and therapeutic areas below before treating it as current-year activity.

Trial completion reliability score

D 55/100

1,244 of 1,444 decided trials (Completed vs. Terminated on ClinicalTrials.gov) reached their planned completion (86.1%), vs. national p10 68.4% / p90 100% among 1,234 sponsors with at least 10 decided trials. Still-open trials (Recruiting, Active-not-recruiting, Not-yet-recruiting) are excluded since they have not reached an outcome yet.

Open and recent trials

1,725 total, page 23 of 35

TERMINATED Phase 4

Comparison of Combination Therapy vs Single Agent Therapy for Treatment of Urge Incontinence.

NCT02176642

TERMINATED NA

TEA vs. PVB vs. PCA in Liver Resection Surgery

NCT02192879

TERMINATED

Changes in fMRI and Neurocognitive Function in Women With Pre-eclampsia

NCT03863639

COMPLETED Phase 1

Adoptive Transfer of Haplo-identical DLI for AML and MDS

NCT02046122

COMPLETED NA

Diabetes Self-Management & Support LIVE

NCT02040038

COMPLETED Phase 4

Impact of Oral Antibiotic Treatment on C. Difficile

NCT02057198

COMPLETED Phase 1

Autologous Umbilical Cord Blood Infusion for Children With Autism Spectrum Disorder (ASD)

NCT02176317

COMPLETED NA

The Effect of Oral Carnitine Supplementation on MRS-derived Mitochondrial Function

NCT02124590

COMPLETED

Older Cancer Caregiver Needs Post Hospital Discharge

NCT02099526

COMPLETED Phase 2

Anti-thrombin III (ATIII) vs Placebo in Children (<7mo) Undergoing Open Congenital Cardiac Surgery

NCT02103114

COMPLETED NA

Enhancing Exercise in Breast Cancer Survivors

NCT01849978

COMPLETED NA

Traditional African Healing Ceremony in a U.S. Population

NCT01873482

COMPLETED

Optimizing Health Outcomes in Patients With Symptomatic Aortic Valve Disease

NCT02266251

COMPLETED NA

Use of Mobile Technology for Intensive Training in Medication Management

NCT02133560

COMPLETED NA

Health Coaching for Glaucoma Patients

NCT02090777

COMPLETED Phase 1

Trial of Neoadjuvant Ipilimumab Followed by Melphalan Via Isolated Limb Infusion for Patients With Unresectable In-transit Extremity Melanoma

NCT02115243

COMPLETED NA

Prader-Willi Syndrome Macronutrient Study

NCT02011360

COMPLETED NA

Simultaneous Risk Factor Control Using Telehealth to slOw Progression of Diabetic Kidney Disease (STOP-DKD)

NCT01829256

COMPLETED NA

Family Health History in Diverse Care Settings (FHH)

NCT01956773

COMPLETED Phase 2

Salvage Therapeutic Radiation With Enzalutamide and ADT in Men With Recurrent Prostate Cancer (STREAM)

NCT02057939

COMPLETED NA

Testing Methods of Self-persuasion Involving Cigarette Smoking

NCT02069483

COMPLETED

Dynamics of the Microbiome in the Premature Infant

NCT02121938

COMPLETED NA

Triceps Surae Trigger Point Size and Muscle Extensibility

NCT02087969

COMPLETED NA

H.O.P.E: Helping Ovarian Cancer Patients Cope

NCT02090582

COMPLETED

Brain Connectivity in Age-Related Macular Degeneration

NCT01996215

COMPLETED NA

The Mobile Health Platform

NCT02099513

COMPLETED Phase 1

Dendreon Lymph Node Biopsy in Metastatic Castrate-Resistant Prostate Cancer

NCT02036918

COMPLETED Phase 2

The Effect of Sponge Versus No-Sponge Placement of Mitomycin-C on the Outcomes of Trabeculectomy With Ex-PRESS Glaucoma Filtration Device

NCT02016898

COMPLETED NA

BABY STEPS II: SMS Scheduled Gradual Reduction Text Messages to Help Pregnant Smokers Quit

NCT01995097

COMPLETED NA

Normal Eyelid Sensation Distribution

NCT02059824

COMPLETED

Pharmacokinetics of Dexmedetomidine in Children During Cardiopulmonary Bypass (CPB)

NCT02059343

COMPLETED NA

Characterization of Circulating Tumor Cells Captured by c-MET (CTC-MET)

NCT02080650

COMPLETED

Evaluating Quality of Life in Patients With Soft Tissue Sarcoma Presenting With Metastatic Lung Disease

NCT02080897

COMPLETED NA

Mobile Sensing of Smoking Behavior

NCT02116283

COMPLETED NA

Feeling and Body Investigators for Pediatric Abdominal Pain

NCT02075437

COMPLETED NA

A High Protein Weight Loss Intervention for Sarcopenic Obesity in Women

NCT02033655

TERMINATED NA

The Impact of Early Follow-up on Readmission Rates in AMI Patients

NCT02276456

TERMINATED NA

RNA Extraction and Amplification From Biopsy Specimens in Subjects With Metastatic Renal Cell Carcinoma (AGS-NTS-017)

NCT02026960

TERMINATED NA

Home Based Exercise Program for Elderly Cancer Patients

NCT01990066

COMPLETED NA

Acute and Chronic Nicotine Modulation of Reinforcement Learning

NCT01830842

COMPLETED NA

Efficacy and Safety of the DASH Diet in Adults With Moderate Chronic Kidney Disease: Pilot Study

NCT02059811

COMPLETED NA

Real Time In-Vivo Dosimetry For Gynecologic Brachytherapy

NCT02040155

COMPLETED NA

Intensive Dysarthria Sessions in Adults and Children With Down Syndrome

NCT01684670

COMPLETED

Mobile App Based Personalized Solutions and Tools for Medication Adherence of Rx Pills

NCT02072005

TERMINATED

Imaging Lens Deposits in Exfoliation Syndrome

NCT02042703

COMPLETED NA

Bone Marrow Aspirate Concentrate (BMAC) Supplementation for Osteochondral Lesions

NCT02011295

COMPLETED Phase 2

Abiraterone, Radiotherapy and Short-Term Androgen Deprivation in Unfavorable Localized Prostate Cancer

NCT01717053

COMPLETED

Pathways to Cardiovascular Disease Prevention (DCRI Central and Statistical Coordinating Center)

NCT04025125

COMPLETED

Who Contributes to the Ordering of CT Scans in Emergency Department Patients?

NCT02040896

COMPLETED NA

Changes in Gut Hormones, Body Composition and Energy Expenditure After Roux-en-Y

NCT02048501

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Phase Distribution

PhaseTrial count
Phase 1 136
Phase 2 175
Phase 3 41
Phase 4 134

What is open in the Duke University pipeline

187 recruiting of 1,725 indexed (11% open); 1,244 completed (72%).

Phase mix: 175 late (III/IV) vs 311 early (I/II) (early-phase heavy).

Top condition: Obesity (15 trials), 9 others listed.

How open-pipeline share is computed

Recruiting share is recruiting_count divided by trial_count for this sponsor in the public registry export. Status can change between pulls; treat the figure as a research-attention snapshot, not product availability.

Duke University: open-pipeline peers nationwide

Peers matched on 1,725 registered trials and 11% open enrollment, not the therapeutic-area sidebar.

Duke University sits at or above the median trial volume and at or above the median recruiting share among these 9 nationwide peers -- the two do not always move together. Source: ClinicalTrials.gov (2026-08-08 snapshot). 2×2 strategic matrix plotting 9 entities by Total trials (X) and Recruiting share (Y), with a crosshair dividing the plot into four quadrants. Higher volume & more openFocused & more openHigher volume, mostly closedSmaller & mostly closed 05001,0001,5002,000 5%10%15%20% Total trials Recruiting share Duke UniversityUniversity of California, San FranciscoStanford UniversityVA Office of Research and DevelopmentPfizerCarnegie Mellon UniversityCAMC Health SystemUConn HealthHartford Hospital
Duke University sits at or above the median trial volume and at or above the median recruiting share among these 9 nationwide peers -- the two do not always move together. Source: ClinicalTrials.gov (2026-08-08 snapshot).

Duke University sits at or above the median trial volume and at or above the median recruiting share among these 9 nationwide peers -- the two do not always move together.

Sponsors near 1,725 trials (± recruiting share)

Sponsors near 11% open enrollment (± trial volume)

What to do with this Duke University page

1,725 registered trials is a research-attention snapshot, not an endorsement of Duke University or any single study.

  • 187 of Duke University's trials are currently recruiting, check each one's own eligibility criteria before contacting a site. Browse recruiting trials
  • Obesity is the condition Duke University studies most, compare against other sponsors active in the same condition before evaluating a specific study. See Obesity trials
  • Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide

Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.

Duke University pipeline card: 1,725 registered trials from official public datasets.Report a data error.