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NCT01830842 · ClinicalTrials.gov registry record · NA
Acute and Chronic Nicotine Modulation of Reinforcement Learning
A NA study of Nicotine Addiction, sponsored by Duke University.
- Completed
- Registry status
- NA
- Development phase
- 54
- Enrollment target
- 1
- Study location
NCT01830842: Completed NA study of Nicotine Addiction, sponsored by Duke University.
NCT01830842 is a NA study of Nicotine Addiction that has completed, run by Duke University. The registered enrollment target is 54 participants, below the 719-participant average among 10 other Nicotine Addiction trials with a reported enrollment target (92% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01830842, a NA study of Nicotine Addiction, has completed, sponsored by Duke University.
- COMPLETED
- Registry status
- NA
- Development phase
- 54 participants
- Enrollment target
- 1
- Study location
Study Summary
The purpose of this study is to use functional magnetic resonance imaging (fMRI) to investigate the acute and chronic effects of nicotine on motivational behavior and prediction error-related neural activation. Nonsmokers (n = 24) and smokers (n = 24) will undergo fMRI scans on two separate occasions while performing a decision-making task that will elicit prediction error signals in the mesocorticolimbic pathway of the brain. Nonsmokers will be scanned once following an acute dose of nicotine and once following placebo administration. Smokers will be scanned once following smoking as usual and once following 24-hours of smoking abstinence, in order to measure the effects of nicotine withdrawal. The study team hypothesizes that acute nicotine will increase the prediction error signal in nonsmokers compared to placebo, and that nicotine withdrawal will decrease the prediction error signal in smokers compared to the normal satiated condition. Furthermore, nonsmokers (during the placebo condition) will have greater prediction error activation than smokers (during the satiated condition). The results of this study will inform whether the initiation and maintenance of smoking behavior could be facilitated by the effects of nicotine on reinforcement learning.
Primary Outcome
The acute and chronic effects of nicotine on the blood oxygen level dependent signal will be measured using functional magnetic resonance imaging. Reward-cue related BOLD signal on an outcome expectation task.
Conditions Studied
Interventions
- DRUG Placebo
- DRUG Nicotine polacrilex
- OTHER satiety
- OTHER abstinence
Study Locations (1)
North Carolina
- Duke University - Durham
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 54 participants |
| Start Date | 2014-02 |
| Est. Completion | 2016-08-31 |
| Phase | NA |
What the finished NCT01830842 record still lists
NCT01830842 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 54 participants, a relatively small participant target, below the 719-participant average among 10 other Nicotine Addiction trials with a reported enrollment target (92% lower).
The record links to 1 condition, with Nicotine Addiction appearing as the primary indexed condition, and to 4 interventions - of which Placebo is the first listed.
NCT01830842 reports a single indexed study location in North Carolina.
Frequently Asked Questions
What is clinical trial NCT01830842 about?
NCT01830842 is a clinical study titled "Acute and Chronic Nicotine Modulation of Reinforcement Learning". The purpose of this study is to use functional magnetic resonance imaging (fMRI) to investigate the acute and chronic effects of nicotine on motivational behavior and prediction error-related neural activation. Nonsmokers (n = 24) and smokers (n = 24) will undergo fMRI scans on two separate occasion...
What is the current status of trial NCT01830842?
This trial is currently completed. It is a NA study. The enrollment target is 54 participants. The study started on 2014-02. Estimated completion is 2016-08-31.
What conditions does trial NCT01830842 study?
This clinical trial studies the following conditions: Nicotine Addiction.
What interventions are being tested in trial NCT01830842?
The interventions under investigation include: Placebo (DRUG), Nicotine polacrilex (DRUG), satiety (OTHER), abstinence (OTHER).
Who is sponsoring clinical trial NCT01830842?
This trial is sponsored by Duke University, which has 1,725 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT01830842 being conducted?
This trial has 1 study location across North Carolina. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Nicotine Addiction
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT01830842's enrollment target sits among peer trials
54 9th of 10 higher than 2 of 10 other Nicotine Addiction trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Nicotine Addiction trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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