Duke University

Open enrollment with an early-phase pipeline tilt

According to ClinicalTrials.gov-derived indexes, Duke University sits in the top decile of US sponsors by registered trial count (#9 of 15,742 sponsors by registered trial count).

1,725 total trials 187 currently recruiting 1244 completed early-phase tilt top decile by trial count

Duke University: 1,725 sponsored US clinical trials, 187 recruiting.

Duke University sponsors 1,725 registered US clinical trials on ClinicalTrials.gov, 187 of them currently recruiting, and 1,244 completed. 175 of these trials are in Phase 3-4 (later-stage) and 311 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Obesity, with 15 trials.

Top-decile sponsor footprint

Duke University ranks in the top decile of sponsors by registered trial count (#9 of 15,742 sponsors by registered trial count). Volume at this scale usually reflects a long institutional pipeline, read phase tilt and therapeutic areas below before treating it as current-year activity.

Trial completion reliability score

D 55/100

1,244 of 1,444 decided trials (Completed vs. Terminated on ClinicalTrials.gov) reached their planned completion (86.1%), vs. national p10 68.4% / p90 100% among 1,234 sponsors with at least 10 decided trials. Still-open trials (Recruiting, Active-not-recruiting, Not-yet-recruiting) are excluded since they have not reached an outcome yet.

Open and recent trials

1,725 total, page 22 of 35

COMPLETED

An Observational Study of Post-cesarean Delivery Respiratory Patterns Using a Non-invasive Minute Ventilation Monitor (Exspiron ™ System)

NCT02903173

COMPLETED

Novel Biomarker for Development of T2D

NCT02326129

COMPLETED

Feasibility Testing of the Quality-monitoring Tool, Qdact, for the Palliative Care Research Cooperative

NCT02411305

COMPLETED NA

Message Framing and Colorectal Cancer Screening

NCT02483832

COMPLETED

Obstructive Sleep Apnea in Pregnancy

NCT02383706

TERMINATED Phase 2

Hyperbaric VO2max Study

NCT02356900

TERMINATED NA

Efficacy and Safety of Low Amplitude Electroconvulsive Therapy

NCT02351843

COMPLETED

The Use of a Dynamic Compression Intramedullary Nail for Tibiotalocalcaneal Arthrodesis

NCT02324907

COMPLETED NA

Treatment for Teens With Alcohol Abuse and Depression

NCT02227589

COMPLETED Phase 2

The Effects of Potassium on Glucose Metabolism in African Americans

NCT02236598

COMPLETED

Nonconvulsive Seizure Identification on Quantitative EEG by Neuro ICU Nurses

NCT02082873

COMPLETED

PEACE: Pediatric Antifungal Comparative Effectiveness

NCT01869829

COMPLETED NA

Evaluating CVD Medication Adherence Program in Low SES

NCT02375737

COMPLETED

BIOPIC: Fungal Biomarkers for Diagnosis and Response to Therapy for Pediatric Candidemia

NCT02220790

COMPLETED Phase 4

TXA vs. Amicar in Total Knee and Hip Arthroplasty

NCT02030821

COMPLETED

Infant Immunity Comparison of Breastfed and Bottlefed Infants

NCT02568579

COMPLETED NA

Mobile Contingency Management for Smoking Cessation in Returning US Veterans

NCT02513069

TERMINATED NA

Virtual Reality for Osteoarthritis Knee Pain Pilot

NCT01899508

COMPLETED Phase 2

Study of High-dose Spironolactone vs. Placebo Therapy in Acute Heart Failure

NCT02235077

COMPLETED

Determine the Prevalence and Severity of Asthma in HIV (Human Immunodeficiency Virus) Infected Patients

NCT02405026

COMPLETED Phase 4

Reducing Pain of Lidocaine Injection

NCT02288364

COMPLETED

Neovascular Morphology and Persistent Disease Activity Among Patients With NV AMD

NCT02367365

COMPLETED

Effect of Feedings on Caffeine in Premature Infants

NCT02293824

COMPLETED Early Phase 1

Intra-Arterial Microdosing: Proof-of-Concept in Humans

NCT02304211

COMPLETED Phase 4

Dexamethasone and Pain Following Total Knee Arthroplasty

NCT02271698

COMPLETED NA

SDOCT-GMPE Software

NCT02235454

COMPLETED

Function and Scoliosis Surgery

NCT02237248

COMPLETED

Molecular Mechanisms Underlying Prostate Cancer Disparities

NCT02229565

COMPLETED NA

Temperature Monitoring With InnerSense Esophageal Temperature Sensor/Feeding Tube After Birth Through Stabilization in VLBW Infants

NCT02311972

COMPLETED

Depression and Heart Failure Disease Progression

NCT02131428

COMPLETED NA

Patient-Reported Preferences Affecting Revascularization Decisions

NCT02272062

COMPLETED NA

Effect of Tourniquet on Sensory Nerve Conduction Threshold (sNCT) and OxyNeuroGram (ONG) Index- A Volunteer Study

NCT01970839

TERMINATED NA

Effects of Chemoradiation and Surgery on Cardiopulmonary Fitness and Tumor Neoplastic Phenotype in Gastrointestinal Malignancies

NCT02235441

TERMINATED

Whole Eye Optical Coherence Tomography (OCT) to Improve Refractive Surgery and Eye Care

NCT03219567

COMPLETED NA

Mobile Pain Coping Skills Training for Cancer Pain

NCT02266017

COMPLETED Phase 1

Contingency Management, Quitting Smoking, and ADHD

NCT02266784

COMPLETED NA

Effects of Smoking Environment on Craving and Smoking

NCT02416986

COMPLETED NA

Hepatitis C Alcohol Reduction Treatment

NCT02176980

COMPLETED NA

mHealth Messages to Sustain Recent Weight Loss - Phase 2

NCT02279017

COMPLETED

Monocyte Phenotypic and Functional Differences

NCT02132182

TERMINATED NA

Medical Home Care for Hematopoietic Stem Cell Transplantation Phase 2

NCT02218151

TERMINATED NA

Effects of Exercise and Improved Nitric Oxide Bioavailability on Arteriovenous Fistula Maturation

NCT02164318

COMPLETED NA

Self-management Interventions for Advanced Breast Cancer

NCT01927081

COMPLETED NA

Comparison of Topical Skin Adhesive to Subcuticular Suture Closure of Implantable Port Incisions

NCT02212977

COMPLETED

Respiratory Viral Infections in Pediatric Transplantation

NCT02260596

COMPLETED NA

The Effect of Prophylactic Antipyretics on Immune Responses and Fever After 2014-2015 and 2015-2016 Inactivated Influenza Vaccine

NCT02212990

COMPLETED NA

Healthy Lifestyles Program for You (HLP4U): Augmenting Childhood Obesity Treatment.

NCT01989065

COMPLETED NA

Improving Memory Performance by Applying Cognitive Training

NCT02216591

COMPLETED NA

Integrative Health Coaching in Community Settings

NCT02186327

COMPLETED Phase 1

Safety Study of Regorafenib With PF-03446962 to Treat Colorectal Cancer

NCT02116894

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Phase Distribution

PhaseTrial count
Phase 1 136
Phase 2 175
Phase 3 41
Phase 4 134

What is open in the Duke University pipeline

187 recruiting of 1,725 indexed (11% open); 1,244 completed (72%).

Phase mix: 175 late (III/IV) vs 311 early (I/II) (early-phase heavy).

Top condition: Obesity (15 trials), 9 others listed.

How open-pipeline share is computed

Recruiting share is recruiting_count divided by trial_count for this sponsor in the public registry export. Status can change between pulls; treat the figure as a research-attention snapshot, not product availability.

Duke University: open-pipeline peers nationwide

Peers matched on 1,725 registered trials and 11% open enrollment, not the therapeutic-area sidebar.

Duke University sits at or above the median trial volume and at or above the median recruiting share among these 9 nationwide peers -- the two do not always move together. Source: ClinicalTrials.gov (2026-08-08 snapshot). 2×2 strategic matrix plotting 9 entities by Total trials (X) and Recruiting share (Y), with a crosshair dividing the plot into four quadrants. Higher volume & more openFocused & more openHigher volume, mostly closedSmaller & mostly closed 05001,0001,5002,000 5%10%15%20% Total trials Recruiting share Duke UniversityUniversity of California, San FranciscoStanford UniversityVA Office of Research and DevelopmentPfizerCarnegie Mellon UniversityCAMC Health SystemUConn HealthHartford Hospital
Duke University sits at or above the median trial volume and at or above the median recruiting share among these 9 nationwide peers -- the two do not always move together. Source: ClinicalTrials.gov (2026-08-08 snapshot).

Duke University sits at or above the median trial volume and at or above the median recruiting share among these 9 nationwide peers -- the two do not always move together.

Sponsors near 1,725 trials (± recruiting share)

Sponsors near 11% open enrollment (± trial volume)

What to do with this Duke University page

1,725 registered trials is a research-attention snapshot, not an endorsement of Duke University or any single study.

  • 187 of Duke University's trials are currently recruiting, check each one's own eligibility criteria before contacting a site. Browse recruiting trials
  • Obesity is the condition Duke University studies most, compare against other sponsors active in the same condition before evaluating a specific study. See Obesity trials
  • Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide

Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.

Duke University pipeline card: 1,725 registered trials from official public datasets.Report a data error.