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NCT02124590 · ClinicalTrials.gov registry record · NA
The Effect of Oral Carnitine Supplementation on MRS-derived Mitochondrial Function
A NA study, sponsored by Duke University.
- Completed
- Registry status
- NA
- Development phase
- 14
- Enrollment target
NCT02124590 is a NA study that has completed, run by Duke University. The registered enrollment target is 14 participants.
The verdict
NCT02124590, a NA study, has completed, sponsored by Duke University.
- COMPLETED
- Registry status
- NA
- Development phase
- 14 participants
- Enrollment target
Study Summary
This is a longitudinal study supported by Pfizer and is a collaboration between DMPI (Duke Molecular Physiology Institute) and DIAL (Duke Image Acquisition Laboratory) to measure the effects of acute exercise on carnitine and acylcarnitine levels in the muscle and on insulin sensitivity in the plasma. This pilot study seeks to explain why moderate intensity exercise provides more improvements in glucose control for pre-diabetic patients than vigorous intensity. The investigators hypothesize that moderate intensity exercise might be beneficial for elderly individuals who are overweight or obese, specifically by: 1. Reducing damaging excess protein acetylation (measured in muscle biopsy), 2. Improving the acylcarnitine/carnitine ratio (measured by MRS), 3. Improving overall mitochondrial function as reflected in reduced phosphocreatine recovery time (measured by MRS) and 4. Increasing insulin sensitivity as measured by a 4-hour oral glucose tolerance test. Investigators intend to use the results of this study to show feasibility in measuring mitochondrial function at Duke for a larger federal grant submission. Investigators hypothesize that carnitine insufficiency might contribute to mitochondrial dysfunction and obesity-related impairments in glucose tolerance and insulin action.
Interventions
- OTHER Acute Exercise
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 14 participants |
| Start Date | 2014-06 |
| Est. Completion | 2014-12 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT02124590
The ClinicalTrials.gov registry entry for NCT02124590 describes a study currently listed as completed, categorized as NA. The registered enrollment target is 14 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Duke University, which has 1,725 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 1 intervention - of which Acute Exercise is the first listed.
NCT02124590 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT02124590 about?
NCT02124590 is a clinical study titled "The Effect of Oral Carnitine Supplementation on MRS-derived Mitochondrial Function". This is a longitudinal study supported by Pfizer and is a collaboration between DMPI (Duke Molecular Physiology Institute) and DIAL (Duke Image Acquisition Laboratory) to measure the effects of acute exercise on carnitine and acylcarnitine levels in the muscle and on insulin sensitivity in the plasm...
What is the current status of trial NCT02124590?
This trial is currently completed. It is a NA study. The enrollment target is 14 participants. The study started on 2014-06. Estimated completion is 2014-12.
What interventions are being tested in trial NCT02124590?
The interventions under investigation include: Acute Exercise (OTHER).
Who is sponsoring clinical trial NCT02124590?
This trial is sponsored by Duke University, which has 1,725 total clinical trials registered on ClinicalTrials.gov.
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